This study addresses the critical need for optimizing heat transfer and fluid flow in porous ring structures, which are essential for various thermal management applications. The aim is to investigate how different parameters such as obstacle length(B), heat source position(D), heat generation coefficient(Q), Hartmann coefficient (Ha), porosity( ), and Rayleigh coefficient (Ra) affect heat transfer and fluid flow characteristics in a porous ring structure with multiple heat sources. The modeling assumes steady-state conditions, isotropic and homogeneous porous media, and uniform heat generation within the obstacles. Finite Element Method (FEM) simulations were employed to analyze the effects of the aforementioned parameters on streamline distributions, temperature profiles, and heat transfer rates. Remarkably, increasing obstacle length and higher porosity generally enhance heat transfer efficiency, while positioning heat sources closer to the outer boundary and higher Rayleigh numbers lead to reduced heat transfer. The study reveals that, contrary to conventional expectations, various parametric changes consistently result in decreased heat transfer, making the porous ring structure suitable for applications requiring thermal isolation or minimized heat leakage.

Warfarin finds human application as anticoagulant therapy. Warfarin usage can cause liver damage and hemorrhage. Besides functioning as anticoagulant and causing continuous bleeding of pests, the mechanism of toxicity of warfarin is unknown. In this study, Wild female and male rats were administrated orally with warfarin for 18 days at 9, 18, 27.5, and 55 mg/kg, respectively. Hepatoxicity was determined by assessing, LD50, leukocyte counts, immunochemistry, histopathology, serum proteins, Western blotting, especially of markers of liver injury, such as AST, ALT & ALP, and markers of antioxidant and oxidative stress markers. Warfarin treatment decreased Nrf2 levels while it increased caspase 3, CYP2C9, COLL1A1. It caused cellular damage and fibrosis of liver. The plasma levels of markers of liver injury, AST, ALT, ALP, bilirubin and transferrin were increased. The plasma levels of albumin, IgG and antitrypsin were decreased. Warfarin treatment decreased RBC and total lymphocyte count while increasing selectively neutrophils. Warfarin exposure caused increased oxidative stress; increased LPO and decreased GSH, SOD, CAT and NO production. Oral exposure of rats with Warfarin leads to increased oxidative stress resulting into liver damage via CYP2C9 mediated by Nrf2 depletion.

Limestone mining waste and its derived CaO were checked as an adsorbents of pb2+, Cu2+, and Cd2+ ions
from water solution. The characterization of Limestone and calcined limestone was studied by using
X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis
(TGA), Scanning Electron Microscope (SEM), and Surface area measurements (BET). The optimum
conditions of sorbent dosage, pH, initial concentration, and contact time factors were investigated
for pristine limestone and calcined limestone absorbents. The results indicate that the optimum initial
concentrations of (Ci) were 1200, 500, and 300 ppm for Pb, Cu, and Cd, respectively, using calcined
limestone adsorbent, while using the pristine limestone adsorbent, the corresponding optimum initial
concentrations were 700, 110, and 50 ppm. In the ternary system sorption, the results indicated that
the selectivity sequence of the studied metals by limestone can be expressed as Pb2+ > Cd2+ > Cu2+, while
calcined limestone exhibits a higher selectivity for Pb2+ compared to Cu2+ and Cd2+. Hence, various
adsorption isotherm and kinetic models were examined to explore different patterns and behaviors of
adsorption. So, the results indicate that calcined limestone has great potential for eliminating cationic
heavy metal species from industrial water solutions.

Uranyl acetate (UA) is used in civilian and military applications, predisposing it to wide dispersion in ecosystems. Using high-performance liquid chromatography, gas chromatography–mass spectrometry, and 2,2-Diphenyl-1-picrylhydrazyl scavenging radical analysis, we confirmed that Moringa oleifera leaf ethanolic extract (MLEE) is rich in biologically active phytochemicals. Thus, this study aims to investigate the possible defensive effect of MLEE against UA-induced testicular dysfunction. To achieve this, rats were divided randomly and evenly into three groups for 14 days. The control group received no treatment, while the UA group received a single intraperitoneal injection of UA at a dose of 5 mg/kg BW dissolved in saline on the 12th day of the experiment, followed by no treatment the following day. The MLEE + UA group received daily oral administration of MLEE (300 mg/kg BW) dissolved in distilled water before exposure to UA intoxication. The disruption observed in the pituitary–gonadal axis of UA-intoxicated rats was characterized by a significant decrease in luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol 17beta levels. Additionally, there was a notable increase in malondialdehyde and a decrease in catalase, superoxide dismutase, reduced glutathione, and nitric oxide, accompanied by an up-regulation in the immuno-expression of nuclear factor-kappa B, indicating a disturbance in the redox balance. The TUNEL assay confirmed a substantial rise in apoptotic cell numbers in the UA group. Testicular histopathological changes, excessive collagen deposition, and reduced glycogen content were evident following UA exposure. However, supplementation with MLEE effectively countered these mentioned abnormalities. MLEE is proposed to combat the toxicological molecular targets in the UA-affected testis by restoring the balance between oxidants and antioxidants while obstructing the apoptotic cascade. MLEE contains an abundance of redox-stabilizing and cytoprotective phytochemicals that have the potential to counteract the mechanistic pathways associated with UA exposure. These findings encourage further research into other plausible protective aspects of Moringa oleifera against the UA challenge.

Petroleum aromatic hydrocarbons are considered one of the most dangerous aquatic pollutants due to their widespread across water bodies, persistence, and extension to the food chain. To our knowledge, there hasn’t been any research investigating the hepatorenoprotective effects of Spirulina platensis (SP) against toxicity induced by these environmental toxicants in fish. Thus, we decided to explore its potential safeguarding against benzene and toluene exposure in adult Clarias gariepinus. To achieve this objective, fish were divided into five groups (60 per group; 20 per replicate). The first group served as a control. The second and third groups were intoxicated with benzene and toluene at doses of 0.762 and 26.614 ng/L, respectively for 15 days. The fourth and fifth groups (SP + benzene and SP + toluene, respectively) were challenged with benzene and toluene as previously mentioned following dietary inclusion of SP at a dose of 5 g/kg diet for 30 days. The marked increase in liver metabolizing enzymes, glucose, total protein, albumin, globulin, albumin/globulin ratio, and creatinine confirmed the hepato- and nephrotoxic impacts of benzene and toluene. These outcomes were coupled with cytopathological affections and excessive collagen deposition. The incorporation of SP in ration formulation, on the contrary, restored the previously mentioned toxicological profile due to its antioxidant and cytoprotective attributes. Regardless of SP intervention, the renal tissues still displayed histo-architectural lesions, because of insufficient dose and timeframe. Additional research will be required to identify the ideal SP remediation regimen.

Environmental pollutant acrylamide has toxic effect on human health. Numerous industries such as the paper, and cosmetics, use acrylamide in their manufacturing. In certain foods, acrylamide arises at extremely high temperatures. Mesenchymal stem cells can shield different tissues from the damaging effects of free radicals induced by acrylamide. This study aimed to compare the therapeutic efficacy against acrylamide-induced toxicity between adipose-derived mesenchymal stem cells (MSCs) and their conditioned media (CM), evaluating which is more effective. Seventy adult male rats were employed in this study, distributed among 5 groups. The control group consisted of 10 rats, while each of the other four groups comprised 15 rats. The AC group received a daily oral acrylamide (AC) dosage of 3 mg/kg. In the AC + AD-MSCs and AC + AD-MSCs CM groups, after 4 weeks of AC administration, rats were injected with 0.65 × 10⁶ AD-MSCs/0.5 ml PBS and 0.5 ml of AD-MSCs CM, respectively, via the caudal vein, and were observed for 15 days. The recovery group (Rec.), subjected to 4 weeks of AC treatment, and was allowed an additional 15 days for recuperation. The result in AC and Rec. groups revealed elevated DNA damage, P53 protein levels, apoptosis, LPO, and testosterone (free and total). In contrast, the administration of CM and the transplanting of AD-MSCs decreased the levels of these proteins. According to histological analysis, treating testicular cells with AD-MSCs mitigated histopathological lesions, fibrosis, and toxicity caused by AC. The regulation of P53, LPO protein levels, and testosterone levels, supported the function of AD-MSCs in lowering testis DNA damage and apoptosis.

Microalgae have well-established health benefits for farmed fish. Thus, this study aims to explore the potential protective effects of Spirulina platensis, Chlorella vulgaris, and Moringa oleifera against pyrogallol-induced hematological, hepatic, and renal biomarkers in African catfish (Clarias gariepinus), as well as the histopathological changes in the liver and kidney. Fish weighing 200 ± 25 g were divided into several groups: group 1 served as the control, group 2 was exposed to 10 mg/L of pyrogallol, and groups 3, 4, and 5 were exposed to the same concentration of pyrogallol, supplemented with S. platensis at 20 g/kg diet, C. vulgaris at 50 g/kg diet, and M. oleifera at 5 g/kg diet, respectively, for 15 days. Exposure to pyrogallol led to decreased packed cell volume (PCV) and lymphocyte count, but these effects were alleviated by microalgae interventions. C. vulgaris and M. oleifera equally restored PCV and increased lymphocyte counts. Supplementation with C. vulgaris and M. oleifera successfully normalized both neutrophil and eosinophil counts. Pyrogallol intoxication engenders an increase in glycemic status, but C. vulgaris and M. oleifera effectively mitigated this rise. Pyrogallol-exposed fish exhibited signs of renal dysfunction, with increased serum creatinine and total cholesterol levels. A significant decrease in both erythrocytic cellular and nuclear abnormalities was observed following supplementation with microalgae. C. vulgaris and M. oleifera showed promise in decreasing serum glucose and creatinine levels, and improving hematological parameters, while S. platensis exhibited limited efficacy in this regard. Exposure to pyrogallol led to a notable decrease in serum superoxide dismutase activity and total antioxidant capacity (TAC), accompanied by an increase in serum malondialdehyde (MDA) levels. Diets enriched with C. vulgaris and M. oleifera effectively restored these parameters to normal levels, whereas S. platensis did not induce significant changes. None of the microalgae improved TAC except for M. oleifera, which significantly enhanced it. MDA levels returned to control levels equally and significantly across all groups. Interleukin-6 levels did not exhibit significant differences between any of the groups. Collectively, the histopathological changes induced by pyrogallol were most prominently alleviated in the pyrogallol + C. vulgaris and pyrogallol + M. oleifera groups, and to a limited degree in the pyrogallol + S. platensis group. While the tested microalgae did not cause hepatic or renal dysfunction, they did lead to metabolic abnormalities. The incorporation of microalgae into the diet holds significant importance in mitigating the metabolic and histological toxicity of pyrogallol and should be considered in the formulation of fish feed