Extrahepatic disorders are recorded with hepatitis E virus (HEV) infection. The impact of HEV infection on the male reproductive system is a query. In this study, we retrospectively analyzed semen from infertile men and prospectively examined the semen from acute hepatitis E patients (AHE) for HEV markers. HEV RNA and HEV Ag were not detectable in the semen of infertile men nor the semen of AHE patients. Although HEV markers were detectable in the urine of patients infected with HEV-1, these markers were absent in their semen. There is no significant difference in the level of reproductive hormones between AHE patients and healthy controls. Semen analysis of AHE patients did not show a notable abnormality and there was no significant difference in the semen quality and sperm characteristics between AHE and healthy controls.

Abstract Background and aim Lung cancer is the number one cause of cancer-related deaths. Dendritic cells (DCs) are heterogeneous components of innate immunity that play a crucial role in the anti-tumor T cell immunity and may represent a promising approach for tumor immunotherapy. In this study, we aimed to evaluate the frequency of the two major subsets of DCs; plasmacytoid dendritic cells (pDCs) and monocytic dendritic cells (mDCs) in non-small cell lung cancer (NCSLC) and correlating them with different clinicopathologic features and survival outcomes. Patients and methods This study was a case-controlled one, included 50 patients with denovo pathologically confirmed NSCLC and 20 healthy controls of comparable age and gender. After diagnosis and staging of patients, the frequency of DCs was evaluated using flow cytometry. Results WeunveiledsignificantlyreducedlevelsofpDCs(P=0.024),andmDCs(P=0.013)inNSCLCpatientscompared to controls. Furthermore, there was a significant accumulation of pDCs in non-metastatic patients compared to metastatic ones (P 0.0001), while there was no significant (P = 0.6) differences in mDCs, and mDCs/pDCs ratio (P = 0.9). There was a Significant negative correlation (r = − 0.3, P = 0.04) between OS and mDCs. On the other hand, there was a significantly higher OS with pDCs ≥ 0.82 compared to patients with pDCs 0.82, log rank Ch2 = 12.128, P 0.0001. Conclusion Despite the controversy about the prognostic role of pDCs not only in NSCLC but also in other solid tumors, our study sheds light on the possible prognostic impact of pDCs and mDCs on treatment outcomes of NSCLC patients.

Abstract Background and aim Lung cancer is the number one cause of cancer-related deaths. Dendritic cells (DCs) are heterogeneous components of innate immunity that play a crucial role in the anti-tumor T cell immunity and may represent a promising approach for tumor immunotherapy. In this study, we aimed to evaluate the frequency of the two major subsets of DCs; plasmacytoid dendritic cells (pDCs) and monocytic dendritic cells (mDCs) in non-small cell lung cancer (NCSLC) and correlating them with different clinicopathologic features and survival outcomes. Patients and methods This study was a case-controlled one, included 50 patients with denovo pathologically confirmed NSCLC and 20 healthy controls of comparable age and gender. After diagnosis and staging of patients, the frequency of DCs was evaluated using flow cytometry. Results WeunveiledsignificantlyreducedlevelsofpDCs(P=0.024),andmDCs(P=0.013)inNSCLCpatientscompared to controls. Furthermore, there was a significant accumulation of pDCs in non-metastatic patients compared to metastatic ones (P 0.0001), while there was no significant (P = 0.6) differences in mDCs, and mDCs/pDCs ratio (P = 0.9). There was a Significant negative correlation (r = − 0.3, P = 0.04) between OS and mDCs. On the other hand, there was a significantly higher OS with pDCs ≥ 0.82 compared to patients with pDCs 0.82, log rank Ch2 = 12.128, P 0.0001. Conclusion Despite the controversy about the prognostic role of pDCs not only in NSCLC but also in other solid tumors, our study sheds light on the possible prognostic impact of pDCs and mDCs on treatment outcomes of NSCLC patients.

This study was done to determine the impact of monieziosis infection combined with hypomicroelementosis on some hematological, biochemical and hormonal parameters of Soviet Merino sheep in the Astrakhan region. 20 sheep, aging 3 years old and average 43±1. 6 kg body weight is used. Sheep were divided into two groups. First group contained 10 sheep and these sheep were naturally infected with monieziosis and clinically were suffered from hypomicroelementosis, emaciation, reduced growth rate, anemia, diarrhea and pale mucosa. Second group contained 10 sheep were apparently healthy and free from internal parasites and they were used as a control group. The first group was given Praziver (praziquantel and ivermectin) for treatment monieziosis, while they intramuscularly injected with Sedimin (selenium, iodine and iron) and were introduced daily into the feed with CoCl 2. Faecal and blood samples from both groups were collected, before and 30 days after treatment, and analyzed for some hematological, biochemical and hormonal parameters. Our results revealed that there was a significant decrease in Hb and RBCs values, while total WBCs and eosinophils were significantly increased in the diseased group than in healthy one. Biochemical analysis showed a significant decrease in serum antioxidant enzymes (CAT, SOD and GSH-Px) and a significant increase in serum DC and MDA in the diseased group as compared with the control group. Hormonal analysis showed a significant increase in ACTH, TSH, Cortisol and a significant decrease in serum T4 and T3. After treatment with Praziver, Sedemin and CoCl2, there was a significant effectiveness to maintain blood parameters within normal levels in the experimental group and increase reproductive outcome from these sheep.

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OBJECTIVE: To determine possible risk factors associated with prostate invasion in patients with squamous cell carcinoma (SCC) of the urinary bladder associated with bilharziasis. METHODS: After obtaining approval from the medical ethics committee, we reviewed the clinical and pathologic data from 236 male patients in our department between January 2006 and October 2010 who were treated with radical cystoprostatectomy and proved to have SCC associated with bilharziasis. We reviewed the clinical and histopathologic data regarding prostate infiltration from SCC of the urinary bladder associated with bilharziasis. RESULTS: Two-hundred thirty-six patients were included in this study. Prostate infiltration was present in 14 patients (5.9%). Tumor located in the bladder neck (P = .000001), tumors >5 cm (P = .009), and advanced clinical tumor stage (P = .000001) were associated with highly statistically significant increased risk of prostate invasion from SCC of the urinary bladder. Different patients' ages, high tumor grade, and regional lymph nodes' metastasis were not associated with increased risk of prostate invasion from SCC of the urinary bladder. CONCLUSION: Prostate infiltration from SCC of the urinary bladder (which is associated with bilharziasis) is not uncommon. Tumor >5 cm, bladder neck tumor, and high clinical tumor stages should be considered at least relative contraindications for prostate-sparing cystectomy. Copyright © 2011 Elsevier Inc. All rights reserved. Comment in • Editorial comment. [Urology. 2011] PMID: 22014965 [PubMed - indexed for MEDLINE]