Objective

To assess the efficacy and safety of alternative magnesium sulfate regimens used as single tocolytic therapy for preventing preterm labor in patients with symptomatic placenta previa and subsequent changes in cervical length.

Methods

The study was a randomized clinical trial conducted from December 2020 to August 2022 at Assiut Women's Health Hospital, Egypt, including pregnant women from 28 to 37 weeks of gestation with a singleton fetus in PTL and symptomatic placenta previa. The eligible women were randomized to either (group 1 or 2). The primary outcome was evaluating the efficacy of two different regimens of magnesium sulfate in postponing delivery in patients with P.P. in PTL for 48 hours and changes in cervical length.

Results

Clinical and pregnancy prolongation data showed no significant difference between the two therapy regimens. The high-dose group had a considerably longer cervical length (cm) at 48 hours (p<0.001). The low-dose group had a lower 4-hour magnesium serum level (3.98±0.60 vs. 4.80±0.91; p<0.001). Furthermore, when comparing subgroups based on obesity, our analysis revealed a significant increase in non-obese women delivering after 48 hours in high and low groups. Cervical length after 48 hours (cm) was also increased in the non-obese high-dose group (p<0.030). Non-obese pregnancies treated with high-maintenance tocolysis achieve a therapeutic level of magnesium than obese patients(36.1% vs.6.9%, p=0.007).

Conclusions

A high magnesium sulfate regimen in symptomatic preterm P,P in non-obese women may be related to potential clinical prolongation of pregnancy, an …

Abstract

BACKGROUND 

Melasma is a common acquired disorder of hyperpigmentation which is difficult to treat.

OBJECTIVE 

We aim to evaluate the efficacy and safety of combined microneedling with trichloroacetic acid in the treatment of melasma.

PATIENTS AND METHODS 

Forty women with facial melasma were included and randomly classified into 2 groups. Group A included 20 patients treated with bimonthly session of trichloroacetic acid 25% peeling (8 sessions) combined with a monthly session of microneedling (4 sessions). Group B included the other 20 patients that were treated by bimonthly trichloroacetic acid 25% peeling session (8 sessions) alone.

RESULTS 

After 1 and 3 months of treatment, the mean melasma area and severity index, modified melasma area and severity index, and melasma severity index scores showed significant improvement in each group (p < .05 for each). At 1 and 3 months, the mean percentages of change of all scores were significantly higher in group A than group B (p < .05).

CONCLUSION 

Combined trichloroacetic acid peel with microneedling is effective and a safe option for treating melasma.

Acne scarring usually causes cosmetic and psychological problems. Our aim of the study was to compare the efficacy of microneedling alone, intradermal injection of platelet rich plasma (PRP) alone and combined microneedling with PRP in the treatment of atrophic post‐acne scars. Thirty adult patients with facial post‐acne scars were randomly recruited and divided into two groups: A and B. Group A: included 15 patients; the left sides of their faces were treated with microneedling by dermapen followed by PRP while on the right side of the faces microneedling alone was performed. Group B: included 15 patients; the left sides of their faces were treated with microneedling by dermapen followed by PRP while the right sides of the faces were treated with intradermal injection of PRP. For both groups, the treatment session was repeated every 3 weeks until clearance of the atrophic acne scars or for four sessions …

Chronic obstructive pulmonary disease (COPD) is a major cause of death and morbidity; it may be accompanied by oxidative stress and inflammation with or without underlying genetic etiology. Finding circulating biomarkers for COPD that can help early diagnosis and predict exacerbation and association with respiratory functions has been challenging. There were 40 healthy participants and 60 COPD patients in this research. The rs2070600 gene variant was examined by PCR-RFLP. Circulating sRAGE and annexin A1 levels were determined by ELISA. GSH and MDA were determined by

Immunotherapy represents a promising therapeutic option for treatment of warts. Different concentrations of Candida antigen (1/100 and 1/1000) and zinc sulfate 2% were not previously compared regarding their efficacy in treatment of cutaneous warts. The present study compared the safety and efficacy of intralesional candida antigen versus intralesional 2% zinc sulfate for treatment of cutaneous warts. This prospective controlled clinical trial included one hundred and five patients presented with common, plantar, and plane warts. Patients were divided randomly into three groups, each group included 35 patients. Group 1 were treated with intralesional candida antigen (Ag) 1/100, Group 2 were treated with intralesional candida Ag 1/1000, and Group 3 were treated with intralesional zinc sulfate 2%. This study found that target warts of group 1 displayed higher rate of complete clearance compared to group 2 and group 3 (94.3%, 77.1, 74.2%), respectively. The present study concluded that intralesional immunotherapy with Candida antigen was more effective than Intralesional 2% zinc sulfate in treatment of cutaneous warts and less painful. Clinical trial registration number is (Clinical Trials.gov Identifier: NCT03158168).