Chronic lymph ocytic leukemia (CLL) is a clonal expansion of small mature lymphocytes accumulating in the blood, bone marrow, and lymphoid organs. The interactions of the CLL microenvironment are known to promote CLL cell survival and proliferation. CD49d, an adhesion molecule belonging to the integrin family mediates cell-to-extracellular matrix and cell-to-cell interactions. CD44 is a glycoprotein and also a major hyaluronan receptor that mediates the response of cells to their cellular microenvironment.

COVID-19 represents a serious global threat due to scarcity of definitive cure and its infectious nature. The death rate of COVID-19 patients admitted to hospitals was quite high, and cytokine storms could be the mechanism of severity. Interleukin-6 (IL6) and C-reactive protein (CRP) may predict severity and mortality. We attempted to determine the role of IL6 and CRP as predictors of death in intensive care unit (ICU) patients. This Cross-sectional hospital study included 100 patients admitted to ICUs at Assiut University Hospitals from October 2020 to October 2021. Data including age, sex and comorbidities were recorded, laboratory investigations included CRP, ferritin, and IL6. Data were collected and analyzed. Morality predictors in ICU patients with COVID-19 infection were older age (> 60 years), presence of diabetes mellitus, chest diseases, CRP> 49, IL-6> 70 pg/ml. In conclusion, early ranking and identification of people, who are at risk of death among ICU patients, by monitoring of CRP, IL6, early treatment of cytokine storm, and good management of pre-existing comorbidities would be a very useful approach to reduce the mortality among ICU patients.

Aim: Describe the parameters of corneal endothelial cell of normal Egyptians and to determine its correlation with sex, age, and refractive eye state. Methods: Non-contact specular microscopy was performed in 390 eyes of healthy Egyptian. Age, sex, refractive state, Endothelial cell density (ECD), the standard deviation of hexagonal cells HEX, coefficient of variation (CV) were analyzed. The system recorded the mean cell density MCD (cell/mm2), mean cell area MCA (μm2), central corneal thickness CCT, and HEX percentage. Results: The population's mean age was 48.90±15.77. There were 158 (40.5%) males and 232 (59.5%) females. The MCD was 2762.27±327.72. The mean CV in the cell size was 30.91±5.50, and the HEX percentage was 65.62±6.39. The mean CCT was 542.48±37.57. The ECD decreased from 2822.32 in the 20-30-year age group to 2475.64 in the 71–80-year age group, with no substantial correlation between ECD and age. There were no substantial differences in HEX percentage, CV, and ECD between females and males. However, there was a statistical difference in CCT between females and males, with a P-value of 0.007. There was a marked difference in ECD between emmetropes, hypermetropic, and myopes, with a P-value of 0.001. Moreover, there was a substantial difference in CCT between emmetropes, hypermetropic, and myopes. Nonetheless, there were no statistically significant differences in HEX percentage and CV among emmetropes, hypermetropic, and myopes. Conclusion: Our study provides normative data for the corneal endothelium in healthy Egyptian eyes, adding to the expanding body of information about CEC parameters in healthy Egyptian eyes.

In this study, prepared acetylated bovine whey (ABW) was tested as a highly efficient hepatoprotective agent like that of the old drug N-acetyl cysteine (NAC) against the induction of iron overloading (IO) in a rat model. The probably prophylacting antioxdative characteristic features that were prominently executed on tissue content of reactive oxygen species (ROS), antioxidative ferritin, and proinflammatory IL-6 via the enhanced tissue protecting Nf-E2-related factor 2 (Nrf2) pathway. The reduction in macrophagic M2 CD163 and Kupffer M1 CD68 as well as apoptotic caspase 3 distribution denoted the efficacy of the targeting cellular prophylacting activity. In addition, the reduced abnormalities in the hepatocellular nuclei, cytoplasmic reticulum, mitochondrial degeneration as well as granular glycoproteins, and secondary lysosomal appearance promoted the more preferable usage of the natural product whey supplement than the risky NAC in IO cases.