Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anemia among Egyptians with chronic hepatitis C (CHC). Genotyping of 3 ITPA gene variants and 2 variants of RBV transporter genes has been performed in 123 patients under pegylated interferon-α/ribavirin treatment. The baseline hemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anemia at 4, 8 and 12 weeks of RBV therapy. In addition, ITPA rs7270101 AC/CC and age predicted anemia after 12 weeks of therapy. In conclusion, the ITPA variant rs1127354C>A significantly predict RBV-induced anemia during the first 3 months of treatment and it is recommended to be assessed before RBV administration.

Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anemia among Egyptians with chronic hepatitis C (CHC). Genotyping of 3 ITPA gene variants and 2 variants of RBV transporter genes has been performed in 123 patients under pegylated interferon-α/ribavirin treatment. The baseline hemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anemia at 4, 8 and 12 weeks of RBV therapy. In addition, ITPA rs7270101 AC/CC and age predicted anemia after 12 weeks of therapy. In conclusion, the ITPA variant rs1127354C>A significantly predict RBV-induced anemia during the first 3 months of treatment and it is recommended to be assessed before RBV administration.

Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anemia among Egyptians with chronic hepatitis C (CHC). Genotyping of 3 ITPA gene variants and 2 variants of RBV transporter genes has been performed in 123 patients under pegylated interferon-α/ribavirin treatment. The baseline hemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anemia at 4, 8 and 12 weeks of RBV therapy. In addition, ITPA rs7270101 AC/CC and age predicted anemia after 12 weeks of therapy. In conclusion, the ITPA variant rs1127354C>A significantly predict RBV-induced anemia during the first 3 months of treatment and it is recommended to be assessed before RBV administration.

Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anemia among Egyptians with chronic hepatitis C (CHC). Genotyping of 3 ITPA gene variants and 2 variants of RBV transporter genes has been performed in 123 patients under pegylated interferon-α/ribavirin treatment. The baseline hemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anemia at 4, 8 and 12 weeks of RBV therapy. In addition, ITPA rs7270101 AC/CC and age predicted anemia after 12 weeks of therapy. In conclusion, the ITPA variant rs1127354C>A significantly predict RBV-induced anemia during the first 3 months of treatment and it is recommended to be assessed before RBV administration.

Study of some heavy metal ions in the groundwater at Assiut- Egypt is an essential ingredient for a healthy. The measured ions and water quality parameters such as: (pH, conductivity, salinity , turbidity, Dissolved Oxygen (DO) ,NO2 ,NO3, NH3, SO4 -2, Ca+2, Mg+2 , Pb+2 , Cd+2 , Ni+2, Cu+2, total Fe, Mn+2, total Cr and Total Hardness (TH) were carried out on groundwater samples at different localities in Assiut city and some countryside, Egypt. Classifications of groundwater samples based on groundwater wells depth. Evaluation of the samples for different uses (drinking and domestic uses, irrigation and industrial purposes), saturation index (SI), and water quality index (WQI) indicated. A systematic calculation of correlation coefficients among was performed.

The New Assiut Barrage and its Hydropower Plant in Egypt was initiated at May, 2012 and it is suggested to end in December, 2017.The project is considered one of the most important industrial projects that established to enhance economy and development. The project energy of about 32 MW may contribute in the main electric grid for population and developmental approaches. Surface water samples from the River Nile, around the proposed project were collected and analyzed according to EPA Method- 1669. The measured values of pH, TDS, EC, DO, COD, Total hardness, and Temperature were recorded and reached 8.3, 183.5, 317.3, 7.7, 19.5, 135, and 25.7 OC respectively and were compared with guidelines stated by the Egyptian law 48/ 1982 concerned with protection of River Nile from pollution . Biological properties were obtained and statistically analyzed and their sample locations were determined by Global Positioning System (GPS). The study helps the Environmental Impact Assessment in the stage of the operation of the hydroelectric power station.

The association equilibria of HQ and HQ–coordinated with some transition metal cations such as: Al(III), Ca(II), Cd(II), Co(II), Cu(II), Fe(III), Mg(II), Ni(II), Pb(II) and Zn(II) ions were studied using potentiometric technique. The association constant (Ka) of HQ was calculated from the average number of protons attached per repeating unit in the HQ (nA) at different pH values. This value of pKa which formed was found to be 6.75.The titration curves revealed that the metal ion replaces protons and coordinates to HQ. In addition, the use of such titration curves could be computed of the formation constants (log b) of the different species exist at equilibrium. The formation constant (log b) for different molar ratios of species such as 1 : 2, 1 : 1 and 2 : 1 for metal : 8-quilonol, in solution were computed and the results were discussed. The value of ń and PL for the metal ions under investigation were calculated at different pH values. The Formation Constant (log b) of the coordinated 8-quilonol based on HQ–Metal ion were computed using ń– PL system. Mathematical calculations of differential change of ń (Dń) gave a sharp signal for calculations of formation constant. From ń there are partial formation constant (log b2, log b3, log b4and log b5) which indicate to the protonation degree. The analyses of potentiometric data helped us to determine each value of the formation constant and/or partial formation constant for the metal ions such as: Al(III), Ca(II), Cd(II), Cu(II), Co(II), Fe(III), Mg(II), Ni(II), Pb(II) and Zn(II) coordinated with 8- Hydroxyquinoline.

The association equilibria of PHQ and PHQ–coordinated with some transition metal cations such as: Al(III), Ca(II), Cd(II), Co(II), Cu(II), Fe(III), Mg(II), Ni(II), Pb(II) and Zn(II) ions were studied using potentiometric technique. The association constant (Ka) of PHQ was calculated from the average number of protons attached per repeating unit in the PHQ matrix (nA) at different pH values. This value of pKa which formed was found to be 7.75. The titration curves revealed that the metal ion replaces protons and coordinates to the polymer matrix. In addition, the use of such titration curves could be computed of the formation constants (log ) of the different species exist at equilibrium. The formation constant (log ) for different molar ratios of species such as 1 : 2, 1 : 1 and 2 : 1 for metal : polymer matrix, in solution were computed and the results were discussed. The value of and PL for the metal ions under investigation were calculated at different pH values. The Formation Constant (log ) of the coordinated polymer based on PHQ–Metal ion were computed using – PL system. Mathematical calculations of differential change of ( ) gave a sharp signal for calculations of formation constant. From there are partial formation constant ( log 1, log 2 and log 3 ) which indicate to the protonation degree. The analyses of potentiometric data helped us to determine each value of the formation constant and/or partial formation constant for the metal ions such as: Al(III), Ca(II), Cd(II), Cu(II), Co(II), Fe(III), Mg(II), Ni(II), Pb(II) and Zn(II) coordinated with PHQ matrix .

8-Hydroxyquinoline, HQ, or poly(8-hydroxyquinoline), PHQ, was immobilized on the activated silica gel for extractive concentration of metal ions. FTIR was used to prove the result caused by the immobilization of PHQ on the surface of functionalized silica gel. The thermal gravimetric analysis (TGA) and differential thermal analysis (DTA) prove that Si–PHQ–Cu is more highly thermally stable and strongly adsorbed water than Si–PHQ. Spectra of the solution produced from substrate of PHQ immobilized on silica gel showed record peak at 305 nm was which was maximized at pH 7.2± 0.1 of the universal buffer solution. By the addition of Cu(II) ion solution, a peak at 380 nm was appeared corresponding to formation of HQ–Cu(II) coordinated complex. Spectra of 100 mg of substrate (Si–HQ, Si–PHQ, or Si–Cu) at pH 7.2±0.1 universal buffer solution was recorded, solutions of metal ions were added, after contact time, filtrate, dissolve the solid precipitate in pure ethanol and record the spectra of this solution. A peak at 380 nm appeared corresponding to HQ–Cu(II) complex. The capacity of Si–HQ for extraction of Cu(II) ion was 10 mmol/g. Immobilization of Cu(II) metal ion on silica gel (Si–Cu) was studied. The maximum amount of HQ that can be extracted was 7 mmol/g. In the case of Fe(III) ion on Si–HQ, new two peaks appeared at 580 and 455 nm. The capacity of Si–HQ for extraction of Fe(III) ion was 20 mmol/g. Addition of Cu(II) on Si–PHQ, a new peak at 380 nm was appeared corresponding to PHQ–Cu(II) coordinated complex. The capacity of Si–PHQ for extraction of Cu(II) ion was 40 mmol/g. While, Si–Cu can extract PHQ, the maximum amount of PHQ that can be extracted was 20 mmol/g. Spectra of Fe(III) ion on Si–PHQ was recorded, new two peaks were appeared at 580 and 455 nm corresponding to the formation ofPHQ–Fe(III). The capacity of Si–PHQfor extraction of Fe(III) ion was 40 mmol/g. PHQ immobilized on silica gel was useful for removal of Iron from the sytron syrup (anti-anemic).

Laparoscopic ovarian drilling (LOD) has been widely used as an effective treatment of anovulatory women with polycystic ovarian syndrome (PCOS). However, there has been a growing concern over a possible damaging effect of this procedure on ovarian reserve. The objective of this study was to investigate the hypothesis that LOD compromises ovarian reserve as measured by post-operative changes in circulating anti-Müllerian hormone (AMH). This meta-analysis included all cohort studies as well as randomised controlled trials (RCTs) investigating serum AMH concentrations and other ovarian reserve markers in women with PCOS undergoing LOD. Various databases were searched including MEDLINE, EMBASE, Dynamed Plus, ScienceDirect, TRIP database, ClinicalTrials.gov and Cochrane Library from January 2000 to December 2016. Sixty studies were identified, of which seven were deemed eligible for this review. AMH data were extracted from each study and entered into the RevMan software to calculate the weighted mean difference (WMD) between pre- and post-operative values. Pooled analysis of all studies (n = 442) revealed a statistically significant decline in serum AMH concentration after LOD (WMD −2.13 ng/mL; 95% confidence interval (CI) −2.97 to −1.30). Subgroup analysis based on duration of follow-up, AMH kit, laterality of surgery and amount of energy applied during LOD consistently showed a statistically significant fall in serum AMH concentration. In conclusion, although LOD seems to markedly reduce circulating AMH, it remains uncertain whether this reflects a real damage to ovarian reserve or normalisation of the high pre-operative serum AMH levels. Further long-term studies on ovarian reserve after LOD are required to address this uncertainty.