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Announcement for Al-Ahliya University Students The midterm (coursework) exam for the Matrouh Pharmacognosy-1 course will be held on Tuesday, 25 November 2025.

إعلان لطلاب الجامعة الأهلية عقد امتحان أعمال السنة لمقرر مطروح (عقاقير – 1) يوم الثلاثاء 25 نوفمبر 2025

It has been decided that the midterm (coursework) exam for the Matrouh  Pharmacognosy-1 course for Al-Ahliya University students will be held on Tuesday, 25/11/2025, from 10:00 AM to 11:00 AM in Hall (2) located beneath the lecture theatres.

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إعلانات الطلاب

Announcement for Second-Year Pharm.D Students Regarding the Practical Exam Date for the Pharmacognosy (2) Course on Sunday, 30 November 2025

إعلان  لطلاب الفرقة الثانية فارم دى عن موعد امتحان العملي لمقرر "عقاقير – 2" يوم الأحد 30 نوفمبر 2025

The Practical Exam for the Pharmacognosy (2) course for Second-Year Pharm.D students will be held on Sunday, 30/11/2025, during the scheduled practical session.

Important Notice
All students must attend the exam in their assigned laboratory.

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إعلانات الطلاب

Announcement for Pharm.D (Clinical Pharmacy – Semester 3) Students Regarding the Practical Exam Date for the Pharmacognosy (2) Course on Wednesday, 26 November 2025

إعلان  لطلاب فارم دى (صيدلة اكلينيكية  فصل 3) عن موعد امتحان العملي لمقرر "عقاقير – 2" يوم الأربعاء 26 نوفمبر 2025

The Practical Exam for the Pharmacognosy (2) course will be held on Wednesday, 26/11/2025, during the scheduled practical session.

Important Notice
All students must attend the exam in their assigned laboratory.

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إعلانات الطلاب

Announcement of Results and Midterm Grade Appeal for the Medicinal Plants course – First-Year Pharm. D (Clinical Pharmacy) Students for the Academic Year 2025/2026

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Medicinal Plants Course Grades for First-Year Pharm.D (Clinical Pharmacy) Students

 

اعلان نتيجة و التماس درجة أعمال السنة لمقرر "نباتات طبية" – الفرقة الأولى فارم دى (صيدلة اكلينيكية) للعام الجامعى 2025/2026

 

Students wishing to submit an appeal regarding the Midterm Exam grade must register their names with the Department Secretariat starting from Sunday, 16/11/2025, until Thursday, 20/11/2025.
The results of the appeal review will be announced for all students who have registered their names with the Department Secretariat.

 

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إعلانات الطلاب

Announcement of Results and Midterm Grade Appeal for the Medicinal Plants course – First-Year Pharm.D Students for the Academic Year 2025/2026

Click below
?
Medicinal Plants Course Grades for Pharm.D Students

اعلان نتيجة و التماس درجة أعمال السنة لمقرر "نباتات طبية" – الفرقة الأولى فارم دى للعام الجامعى 2025/2026

 

Students wishing to submit an appeal regarding the Midterm Exam grade must register their names with the Department Secretariat starting from Sunday, 16/11/2025, until Thursday, 20/11/2025.
The results of the appeal review will be announced for all students who have registered their names with the Department Secretariat.

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إعلانات الطلاب

Meeting of the Executive Committee (Clinical Pharmacy Program) That will be on Sunday, November 16, 2025

God willing, the Executive Committee meeting and That will be on Sunday, November 16, 2025 at 10:00 AM. The meeting will take place in the Faculty Council Hall, 5th Floor (Administrative Building)

Dean of the Faculty

                                                                          (Prof. Gihan Nabil Hassan Fetih)

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خبر عام

Meeting of the Libraries Committee of the Faculty of Pharmacy on Sunday, November 16, 2025 at 11:00 AM

God willing, the meeting of the Libraries Committee at the Faculty of Pharmacy Pharmacy on Sunday, November 16, 2025 at 11:00 AM at the invitation of Professor Mrs. Professor Dr. Gihan Nabil Hassan Fetih

This meeting will be held in the office of Prof. Dr. / Dean of the Faculty  - Fifth Floor (Administrative Building).

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خبر عام

The department announces the holding of a scientific seminar to present the research project results of Excellence Program students – First Round for the academic year 2025/2026.

قسم الكيمياء العضوية الصيدليةعن عقد حلقة علمية لعرض نتائج المشروع البحثي لطلاب الامتياز – الدورة الأولى للعام الجامعى 2025/2026

The seminar will be held on Thursday, November 13, 2025, at 10:00 a.m. in the department’s lecture hall, covering the research projects conducted during the period from October 5, 2025, to November 13, 2025.

God is the Grantor of success.

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قسم الكيمياء العضوية

A novel nanoparticle glutathione and Lepidium sativum treatment for gentamicin-induced acute renal failure in rats

Research Abstract

Acute renal failure (ARF) is a sudden, significant, and often reversible decline in kidney function, with 25% of all hospital-administered pharmaceuticals potentially causing nephrotoxicity. The study investigates the effectiveness of a novel nanoparticle (NP) formulation of glutathione (GSH) and Lepidium sativum (LS) in improving therapeutic outcomes in a rat model of ARF. Sixty adult male albino rats were allocated into ten groups, comprising six rats each, for the study. ARF was created by daily gentamicin (GN) administration for seven consecutive days and various treatment protocols, including chitosan (CS) NPs, spanlastics NPs, as well as conventional, NP formulations of GSH, LS, and their respective combinations. The effect was evaluated through various tests, and properties of nanoparticles were confirmed through characterization processes. The NP compositions markedly enhanced renal function, as seen by reduced urine concentrations of albumin and glucose. Furthermore, the serum concentrations of creatinine (SCr), blood urea nitrogen (BUN), and cystatin C were decreased. Tissue concentrations of nitrite, superoxide dismutase (SOD), and malondialdehyde (MDA), as markers of oxidative stress, were enhanced by both conventional and NP formulations. Additionally, they decreased inflammatory markers such as kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6). Histological analysis and immunohistochemical testing revealed that the combination therapy, particularly with the nanoforms, significantly decreased caspase 3 cellular immunoexpression, a sign of kidney cellular damage. The findings show that the ARF renal damage is considerably reduced when NPs containing GSH and LS are administered together. The study suggests a promising pharmacological approach for enhancing kidney regeneration and preserving renal function, potentially aiding in new therapeutic interventions for ARF treatment.

Research Authors
Mahmoud S. Sabra, Essmat A. H. Allam, Madeha H. A. Darwish, Enas A. Abdelhafez, Abeer S. Hassan, Ahmed A. N. Ahmed, Hoda S. Sherkawy & Marwa G. Gamea
Research Date
Research Department
Research Journal
Scientific Reports
Research Member
Research Vol
15
Research Year
2025
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