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Changes in insulin structure may alter the way it interacts with insulin and insulin-like growth factor-1 receptors. Possible associations between the use of the long-acting insulin analog, glargine, and an increased risk of cancer have been widely examined. Strong evidence indicates a role for exogenous insulin or analogs in promoting cancer growth in diabetic patients. The clinical relevance of this pro-cancer effect of insulin in diabetic patients, however, is still unclear. In this study, the genotoxic and cytotoxic potential of insulin glargine (5, 12.5 and 25I.U/kg, S.C. daily for 2 weeks) was evaluated against the nicotinamide (NA-230mg/kg) and streptozotocin (STZ-65mg/kg) induced somatic and germinal cells defect using a battery of in vivo cytogenetic assays such as the micronucleus, chromosome aberration, mitotic index and sperm abnormality test in male Wistar rats. The obtained results demonstrated that insulin glargine significantly reduced the diabetes-induced genetic damage and cell proliferation changes in somatic cells. Moreover, the administration of insulin glargine reduced the diabetes-induced genetic damage in germinal cells. The results suggest that insulin glargine is not genotoxic or cytotoxic compound and its use does not present a carcinogenic risk.

Changes in insulin structure may alter the way it interacts with insulin and insulin-like growth factor-1 receptors. Possible associations between the use of the long-acting insulin analog, glargine, and an increased risk of cancer have been widely examined. Strong evidence indicates a role for exogenous insulin or analogs in promoting cancer growth in diabetic patients. The clinical relevance of this pro-cancer effect of insulin in diabetic patients, however, is still unclear. In this study, the genotoxic and cytotoxic potential of insulin glargine (5, 12.5 and 25I.U/kg, S.C. daily for 2 weeks) was evaluated against the nicotinamide (NA-230mg/kg) and streptozotocin (STZ-65mg/kg) induced somatic and germinal cells defect using a battery of in vivo cytogenetic assays such as the micronucleus, chromosome aberration, mitotic index and sperm abnormality test in male Wistar rats. The obtained results demonstrated that insulin glargine significantly reduced the diabetes-induced genetic damage and cell proliferation changes in somatic cells. Moreover, the administration of insulin glargine reduced the diabetes-induced genetic damage in germinal cells. The results suggest that insulin glargine is not genotoxic or cytotoxic compound and its use does not present a carcinogenic risk.

Objectives: To evaluate the outcomes of combined Mathieu and Snodgrass urethroplasty for distal hypospadias repair and to compare them with the two techniques separately. Methods: Between January 2006 and February 2009, patients with distal hypospadias were prospectively randomized to undergo one of the three following urethroplasty techniques: Mathieu urethroplasty, Snodgrass urethroplasty or a combination of the two. Operative time, intraoperative, early and late postoperative complications were reported for each ...

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Background. Chronic suppurative otitis media (CSOM) remains one of the most common childhood chronic infectious diseases worldwide, affecting diverse racial and cultural groups in both developing and industrialized countries. Aim of the Study. This study aimed to assess the impact of educational program on the management of children with CSOM. Subjects and Methods. An experimental study design was used.This study included 100 children of both sexes of 2 years and less of age with CSOM. Those children were divided into 3 groups: group I: it involved 50 children with CSOM (naive) who received the designed educational program; control group: it involved 50 children who were under the traditional treatment and failed to respond; group II: those children in the control group were given the educational program and followed up in the same way as group I and considered as group II. Tools of the Study. Tool I is a structured questionnaire interview sheet for mothers. It consists of four parts: (1) personal and sociodemographic characteristics of child and (2) data about risk factors of otitis media (3) assessment of maternal practice about care of children with suppurative otitis medi (4) diagnostic criteria for suppurative otitis media. Tool II is the educational program: an educational program was developed by the researchers based on the knowledge and practices needs. This study was carried out through a period of 9 months starting from September 2013 to May 2014.The educational program was implemented for mothers of children with CSOM in the form of 5 scheduled sessions at the time of diagnosis, after one week, 1, 3, and 6 months. Results. There were significant differences between children who received the educational program and control group regarding the response to treatment after one and 3 months. The percentages of complete cure increased progressively 32%, 60%, and 84% after 1, 3, and 6 months in group I while they were 24%, 44%, and 64% in group II, respectively. Cure (dry perforation) was 64%, 36%, and 12% among children of group I after 1, 3, and 6 months while it was 64%, 44%, and 24% in group II, respectively. The percentages of compliance to the educational program improved with time in both groups: 44%, 64%, and 80% in group I and 32%, 48%, and 56% in group II after 1, 3, and 6 months, respectively.The percentages of cure were statistically significantly higher among children with complete compliance with the educational program in both groups in comparison to those with incomplete compliance (P = 0.000 for both). Conclusions. From this study we can conclude that the majority of children with CSOM had one or more risk factors for occurrence of the disease; the educational program is effective for management of CSOM (whether cure or complete cure); the higher the compliance of mothers with the program the higher the response rate; regular followup and explanation of the importance of the program played an important role in the compliance with the program.

Changes in insulin structure may alter the way it interacts with insulin and insulin-like growth factor-1 receptors. Possible associations between the use of the long-acting insulin analog, glargine, and an increased risk of cancer have been widely examined. Strong evidence indicates a role for exogenous insulin or analogs in promoting cancer growth in diabetic patients. The clinical relevance of this pro-cancer effect of insulin in diabetic patients, however, is still unclear. In this study, the genotoxic and cytotoxic potential of insulin glargine (5, 12.5 and 25I.U/kg, S.C. daily for 2 weeks) was evaluated against the nicotinamide (NA-230mg/kg) and streptozotocin (STZ-65mg/kg) induced somatic and germinal cells defect using a battery of in vivo cytogenetic assays such as the micronucleus, chromosome aberration, mitotic index and sperm abnormality test in male Wistar rats. The obtained results demonstrated that insulin glargine significantly reduced the diabetes-induced genetic damage and cell proliferation changes in somatic cells. Moreover, the administration of insulin glargine reduced the diabetes-induced genetic damage in germinal cells. The results suggest that insulin glargine is not genotoxic or cytotoxic compound and its use does not present a carcinogenic risk.

Changes in insulin structure may alter the way it interacts with insulin and insulin-like growth factor-1 receptors. Possible associations between the use of the long-acting insulin analog, glargine, and an increased risk of cancer have been widely examined. Strong evidence indicates a role for exogenous insulin or analogs in promoting cancer growth in diabetic patients. The clinical relevance of this pro-cancer effect of insulin in diabetic patients, however, is still unclear. In this study, the genotoxic and cytotoxic potential of insulin glargine (5, 12.5 and 25I.U/kg, S.C. daily for 2 weeks) was evaluated against the nicotinamide (NA-230mg/kg) and streptozotocin (STZ-65mg/kg) induced somatic and germinal cells defect using a battery of in vivo cytogenetic assays such as the micronucleus, chromosome aberration, mitotic index and sperm abnormality test in male Wistar rats. The obtained results demonstrated that insulin glargine significantly reduced the diabetes-induced genetic damage and cell proliferation changes in somatic cells. Moreover, the administration of insulin glargine reduced the diabetes-induced genetic damage in germinal cells. The results suggest that insulin glargine is not genotoxic or cytotoxic compound and its use does not present a carcinogenic risk.

Objectives: To evaluate the outcomes of combined Mathieu and Snodgrass urethroplasty for distal hypospadias repair and to compare them with the two techniques separately. Methods: Between January 2006 and February 2009, patients with distal hypospadias were prospectively randomized to undergo one of the three following urethroplasty techniques: Mathieu urethroplasty, Snodgrass urethroplasty or a combination of the two. Operative time, intraoperative, early and late postoperative complications were reported for each ...

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