The aim of this study was to identify the relative frequency of pediatric patients with Glycogen storage disease type-I (GSD-I) attending outpatient's pediatric clinics or inpatients pediatric departments of Assiut, Sohag and Qena university hospitals, Upper Egypt. This case control study was carried out on 40 pediatric patients, and 40 healthy age and sex matched subjects as a control. Plasma level of lactate, biotinidase and uric acid were determined by using commercially available assay kit in both patient and control groups. Liver biopsy for histopathological examination and glucose-6-phosphatase (G6Pase) assay for patients only when needed. Plasma level of lactate, biotinidase and uric acid were significantly higher of GSD-I patients than control. The definite diagnosis of GSD-I patients was by assay of G6Pase in the biopsied liver tissue homogenates which showed statistically significant lower level when compared with the control group. The relative frequency of GSD-I in Upper Egypt is 5/100,000. It has to be kept in mind whenever failure to thrive, hepatomegaly, fasting hypoglycemia and raised aminotransferases are present. Elevated plasma biotinidase is considered better positive than negative in prediction of GSD-I with higher sensitivity and low false negative rate.

The aim of this study was to identify the relative frequency of pediatric patients with Glycogen storage disease type-I (GSD-I) attending outpatient's pediatric clinics or inpatients pediatric departments of Assiut, Sohag and Qena university hospitals, Upper Egypt. This case control study was carried out on 40 pediatric patients, and 40 healthy age and sex matched subjects as a control. Plasma level of lactate, biotinidase and uric acid were determined by using commercially available assay kit in both patient and control groups. Liver biopsy for histopathological examination and glucose-6-phosphatase (G6Pase) assay for patients only when needed. Plasma level of lactate, biotinidase and uric acid were significantly higher of GSD-I patients than control. The definite diagnosis of GSD-I patients was by assay of G6Pase in the biopsied liver tissue homogenates which showed statistically significant lower level when compared with the control group. The relative frequency of GSD-I in Upper Egypt is 5/100,000. It has to be kept in mind whenever failure to thrive, hepatomegaly, fasting hypoglycemia and raised aminotransferases are present. Elevated plasma biotinidase is considered better positive than negative in prediction of GSD-I with higher sensitivity and low false negative rate.

The aim of this study was to identify the relative frequency of pediatric patients with Glycogen storage disease type-I (GSD-I) attending outpatient's pediatric clinics or inpatients pediatric departments of Assiut, Sohag and Qena university hospitals, Upper Egypt. This case control study was carried out on 40 pediatric patients, and 40 healthy age and sex matched subjects as a control. Plasma level of lactate, biotinidase and uric acid were determined by using commercially available assay kit in both patient and control groups. Liver biopsy for histopathological examination and glucose-6-phosphatase (G6Pase) assay for patients only when needed. Plasma level of lactate, biotinidase and uric acid were significantly higher of GSD-I patients than control. The definite diagnosis of GSD-I patients was by assay of G6Pase in the biopsied liver tissue homogenates which showed statistically significant lower level when compared with the control group. The relative frequency of GSD-I in Upper Egypt is 5/100,000. It has to be kept in mind whenever failure to thrive, hepatomegaly, fasting hypoglycemia and raised aminotransferases are present. Elevated plasma biotinidase is considered better positive than negative in prediction of GSD-I with higher sensitivity and low false negative rate.

The aim of this study was to identify the relative frequency of pediatric patients with Glycogen storage disease type-I (GSD-I) attending outpatient's pediatric clinics or inpatients pediatric departments of Assiut, Sohag and Qena university hospitals, Upper Egypt. This case control study was carried out on 40 pediatric patients, and 40 healthy age and sex matched subjects as a control. Plasma level of lactate, biotinidase and uric acid were determined by using commercially available assay kit in both patient and control groups. Liver biopsy for histopathological examination and glucose-6-phosphatase (G6Pase) assay for patients only when needed. Plasma level of lactate, biotinidase and uric acid were significantly higher of GSD-I patients than control. The definite diagnosis of GSD-I patients was by assay of G6Pase in the biopsied liver tissue homogenates which showed statistically significant lower level when compared with the control group. The relative frequency of GSD-I in Upper Egypt is 5/100,000. It has to be kept in mind whenever failure to thrive, hepatomegaly, fasting hypoglycemia and raised aminotransferases are present. Elevated plasma biotinidase is considered better positive than negative in prediction of GSD-I with higher sensitivity and low false negative rate.

The aim of this study was to identify the relative frequency of pediatric patients with Glycogen storage disease type-I (GSD-I) attending outpatient's pediatric clinics or inpatients pediatric departments of Assiut, Sohag and Qena university hospitals, Upper Egypt. This case control study was carried out on 40 pediatric patients, and 40 healthy age and sex matched subjects as a control. Plasma level of lactate, biotinidase and uric acid were determined by using commercially available assay kit in both patient and control groups. Liver biopsy for histopathological examination and glucose-6-phosphatase (G6Pase) assay for patients only when needed. Plasma level of lactate, biotinidase and uric acid were significantly higher of GSD-I patients than control. The definite diagnosis of GSD-I patients was by assay of G6Pase in the biopsied liver tissue homogenates which showed statistically significant lower level when compared with the control group. The relative frequency of GSD-I in Upper Egypt is 5/100,000. It has to be kept in mind whenever failure to thrive, hepatomegaly, fasting hypoglycemia and raised aminotransferases are present. Elevated plasma biotinidase is considered better positive than negative in prediction of GSD-I with higher sensitivity and low false negative rate.

Objective: The purpose of this study is to evaluate the benefit of use of three-dimensional ultrasound multi-slice view in detailed assessment of adnexal masses morphology. Methods: Two-hundred thirty one patients with adnexal masses elected for surgery at Woman’s Health Center, Assiut, Egypt between October 2012 and October 2013 were recruited for the study. Each patient had 2D ultrasound and detailed morphological evaluation was reported. Then, 3D ultrasound volumes were obtained. The stored 3D volumes were then digitally analyzed using 3D ultrasound multi-slice view. The results of 2D, 3D ultrasound multi-slice were compared to the postoperative histopathological findings. Results: The mean age of included patients was 30.2 ± 12.7 years. Overall, 189 patients (81.8%) confirmed to have benign masses, and 42 patients (18.2%) with malignant masses according to their final histopathological analysis. Subjective assessment by 2D ultrasound correctly classified 95.6% of benign masses and 87% of malignant masses. On detailed assessment of the masses by 3D ultrasound multi-slice view, there was agreement in morphological assessment of all masses except in 3 cases in which 3D ultrasound multi-slice view permitted better description of their morphological criteria and hence changing the presumed diagnosis and management. Conclusions: The ability of detailed analysis of the volumes taken during 3D ultrasound using multi-slice view can aid in better morphological assessment of adnexal masses especially in detection of papillary projections in adnexal cysts. This information is valuable in deciding the optimal management of adnexal masses in some cases.

Objective: The purpose of this study is to evaluate the benefit of use of three-dimensional ultrasound multi-slice view in detailed assessment of adnexal masses morphology. Methods: Two-hundred thirty one patients with adnexal masses elected for surgery at Woman’s Health Center, Assiut, Egypt between October 2012 and October 2013 were recruited for the study. Each patient had 2D ultrasound and detailed morphological evaluation was reported. Then, 3D ultrasound volumes were obtained. The stored 3D volumes were then digitally analyzed using 3D ultrasound multi-slice view. The results of 2D, 3D ultrasound multi-slice were compared to the postoperative histopathological findings. Results: The mean age of included patients was 30.2 ± 12.7 years. Overall, 189 patients (81.8%) confirmed to have benign masses, and 42 patients (18.2%) with malignant masses according to their final histopathological analysis. Subjective assessment by 2D ultrasound correctly classified 95.6% of benign masses and 87% of malignant masses. On detailed assessment of the masses by 3D ultrasound multi-slice view, there was agreement in morphological assessment of all masses except in 3 cases in which 3D ultrasound multi-slice view permitted better description of their morphological criteria and hence changing the presumed diagnosis and management. Conclusions: The ability of detailed analysis of the volumes taken during 3D ultrasound using multi-slice view can aid in better morphological assessment of adnexal masses especially in detection of papillary projections in adnexal cysts. This information is valuable in deciding the optimal management of adnexal masses in some cases.

Objective: The purpose of this study is to evaluate the benefit of use of three-dimensional ultrasound multi-slice view in detailed assessment of adnexal masses morphology. Methods: Two-hundred thirty one patients with adnexal masses elected for surgery at Woman’s Health Center, Assiut, Egypt between October 2012 and October 2013 were recruited for the study. Each patient had 2D ultrasound and detailed morphological evaluation was reported. Then, 3D ultrasound volumes were obtained. The stored 3D volumes were then digitally analyzed using 3D ultrasound multi-slice view. The results of 2D, 3D ultrasound multi-slice were compared to the postoperative histopathological findings. Results: The mean age of included patients was 30.2 ± 12.7 years. Overall, 189 patients (81.8%) confirmed to have benign masses, and 42 patients (18.2%) with malignant masses according to their final histopathological analysis. Subjective assessment by 2D ultrasound correctly classified 95.6% of benign masses and 87% of malignant masses. On detailed assessment of the masses by 3D ultrasound multi-slice view, there was agreement in morphological assessment of all masses except in 3 cases in which 3D ultrasound multi-slice view permitted better description of their morphological criteria and hence changing the presumed diagnosis and management. Conclusions: The ability of detailed analysis of the volumes taken during 3D ultrasound using multi-slice view can aid in better morphological assessment of adnexal masses especially in detection of papillary projections in adnexal cysts. This information is valuable in deciding the optimal management of adnexal masses in some cases.

This study was done to determine if there are differences in individual characteristics, clinical presentation and sonographic appearance between patients with adnexal masses managed surgically and those managed expectantly, and to state the different lines of management of adnexal masses practiced in Assiut University hospital. A cross sectional prospective study was conducted at Assiut University Hospital, Egypt between October 2012 and September 2013 included all patients presented with an adnexal mass which was detected either clinically or diagnosed by ultrasonography elsewhere. In conclusion, this study showed that Ultrasonography is the cornerstone in deciding the optimum modality of management of adnexal masses. Surgical intervention through laparotomy was the most common modality of management practiced in Assiut University hospital, while expectant management was offered for certain benign looking masses under strict follow up.

This study was done to determine if there are differences in individual characteristics, clinical presentation and sonographic appearance between patients with adnexal masses managed surgically and those managed expectantly, and to state the different lines of management of adnexal masses practiced in Assiut University hospital. A cross sectional prospective study was conducted at Assiut University Hospital, Egypt between October 2012 and September 2013 included all patients presented with an adnexal mass which was detected either clinically or diagnosed by ultrasonography elsewhere. In conclusion, this study showed that Ultrasonography is the cornerstone in deciding the optimum modality of management of adnexal masses. Surgical intervention through laparotomy was the most common modality of management practiced in Assiut University hospital, while expectant management was offered for certain benign looking masses under strict follow up.