Introduction: Psoriasis is a chronic inflammatory skin disease with systemic comorbidities as metabolic syndrome. Interleukin- 17(IL-17) has been identified as a central player in psoriasis associated inflammation. Objective: To investigate serum IL-17 levels in relation to metabolic disturbances in psoriasis. Materials and methods: Serum Il-17 levels were measured in 55 patients with psoriasis (26 having metabolic syndrome) and 50 healthy volunteers using the ELIZA method. Results: Serum IL-17 levels were higher in psoriasis patients than controls (P=0.03), and in psoriatic patients with metabolic syndrome than psoriatic patients without metabolic syndrome (P=0.043). Serum IL-17 level was particularly increased in the presence of dyslipidemia and obesity (P=0.001 and 0.041 respectively). Conclusion: Proinflammatory IL-17 in patients with psoriasis seems to be enhanced in the presence of metabolic syndrome particularly related to obesity and dyslipidemia.

Introduction: Psoriasis is a chronic inflammatory skin disease with systemic comorbidities as metabolic syndrome. Interleukin- 17(IL-17) has been identified as a central player in psoriasis associated inflammation. Objective: To investigate serum IL-17 levels in relation to metabolic disturbances in psoriasis. Materials and methods: Serum Il-17 levels were measured in 55 patients with psoriasis (26 having metabolic syndrome) and 50 healthy volunteers using the ELIZA method. Results: Serum IL-17 levels were higher in psoriasis patients than controls (P=0.03), and in psoriatic patients with metabolic syndrome than psoriatic patients without metabolic syndrome (P=0.043). Serum IL-17 level was particularly increased in the presence of dyslipidemia and obesity (P=0.001 and 0.041 respectively). Conclusion: Proinflammatory IL-17 in patients with psoriasis seems to be enhanced in the presence of metabolic syndrome particularly related to obesity and dyslipidemia.

Introduction: Psoriasis is a chronic inflammatory skin disease with systemic comorbidities as metabolic syndrome. Interleukin- 17(IL-17) has been identified as a central player in psoriasis associated inflammation. Objective: To investigate serum IL-17 levels in relation to metabolic disturbances in psoriasis. Materials and methods: Serum Il-17 levels were measured in 55 patients with psoriasis (26 having metabolic syndrome) and 50 healthy volunteers using the ELIZA method. Results: Serum IL-17 levels were higher in psoriasis patients than controls (P=0.03), and in psoriatic patients with metabolic syndrome than psoriatic patients without metabolic syndrome (P=0.043). Serum IL-17 level was particularly increased in the presence of dyslipidemia and obesity (P=0.001 and 0.041 respectively). Conclusion: Proinflammatory IL-17 in patients with psoriasis seems to be enhanced in the presence of metabolic syndrome particularly related to obesity and dyslipidemia.

Introduction: Solar lentigines are of great aesthetical concern for many patients. Although cryotherapy is the golden standard treatment, it may be associated with some side effects. Trichloroacetic acid (TCA) peeling may be an effective alternative but with some concerns regarding potential tumorigenesis. Cryopeeling technique would be better tolerated with improving the entire sun-damaged skin region. Objective: To evaluate the efficacy and side-effects of cryopeeling compared with TCA 35% peeling in the treatment of solar lentigines on the dorsum of the hands and assess their influence on the number of epidermal LCs. Material and Methods: Twenty-five patients were included in the study. The right hand of each patient was treated with TCA 35%, and the left hand with cryopeeling. Two treatment sessions were done three weeks apart. Evaluations were scheduled at weeks 0, 3, and 8. Skin lesions were biopsied before and 3 weeks after treatment for immunohistochemical staining for CD1a+ epidermal LCs. Results: After the first session, the number of lentigines was reduced only in the hand treated with cryopeeling (p 0.001) and reduced for both cryopeeling and TCA treated hands at the end of the study (p0.001, p=0.004, respectively). Cryopeeling produced significant lightening (p= 0.05) compared with TCA 35%. Blistering, hyper/hypopigmentation were reported side effects with cryopeeling, whereas only hyperpigmentation was noted after TCA peeling. The number of epidermal LCs remained at about the pretreatment number in cryopeeling treated skin (p= 0.058), though they decreased after TCA peeling compared with both untreated (p0.001) and cryopeeling treated skin (p=0.001). Conclusions: Cryopeeling provided faster and superior improvement of lentigines compared with TCA peeling. Cryopeeling seems to have little effect on LCs, in contrast to TCA peeling which might exert inhibitory effect on skin immunity through reduction of epidermal LCs, suggesting a possible tumorigenic effect of TCA.

Introduction: Solar lentigines are of great aesthetical concern for many patients. Although cryotherapy is the golden standard treatment, it may be associated with some side effects. Trichloroacetic acid (TCA) peeling may be an effective alternative but with some concerns regarding potential tumorigenesis. Cryopeeling technique would be better tolerated with improving the entire sun-damaged skin region. Objective: To evaluate the efficacy and side-effects of cryopeeling compared with TCA 35% peeling in the treatment of solar lentigines on the dorsum of the hands and assess their influence on the number of epidermal LCs. Material and Methods: Twenty-five patients were included in the study. The right hand of each patient was treated with TCA 35%, and the left hand with cryopeeling. Two treatment sessions were done three weeks apart. Evaluations were scheduled at weeks 0, 3, and 8. Skin lesions were biopsied before and 3 weeks after treatment for immunohistochemical staining for CD1a+ epidermal LCs. Results: After the first session, the number of lentigines was reduced only in the hand treated with cryopeeling (p 0.001) and reduced for both cryopeeling and TCA treated hands at the end of the study (p0.001, p=0.004, respectively). Cryopeeling produced significant lightening (p= 0.05) compared with TCA 35%. Blistering, hyper/hypopigmentation were reported side effects with cryopeeling, whereas only hyperpigmentation was noted after TCA peeling. The number of epidermal LCs remained at about the pretreatment number in cryopeeling treated skin (p= 0.058), though they decreased after TCA peeling compared with both untreated (p0.001) and cryopeeling treated skin (p=0.001). Conclusions: Cryopeeling provided faster and superior improvement of lentigines compared with TCA peeling. Cryopeeling seems to have little effect on LCs, in contrast to TCA peeling which might exert inhibitory effect on skin immunity through reduction of epidermal LCs, suggesting a possible tumorigenic effect of TCA.

Introduction: Solar lentigines are of great aesthetical concern for many patients. Although cryotherapy is the golden standard treatment, it may be associated with some side effects. Trichloroacetic acid (TCA) peeling may be an effective alternative but with some concerns regarding potential tumorigenesis. Cryopeeling technique would be better tolerated with improving the entire sun-damaged skin region. Objective: To evaluate the efficacy and side-effects of cryopeeling compared with TCA 35% peeling in the treatment of solar lentigines on the dorsum of the hands and assess their influence on the number of epidermal LCs. Material and Methods: Twenty-five patients were included in the study. The right hand of each patient was treated with TCA 35%, and the left hand with cryopeeling. Two treatment sessions were done three weeks apart. Evaluations were scheduled at weeks 0, 3, and 8. Skin lesions were biopsied before and 3 weeks after treatment for immunohistochemical staining for CD1a+ epidermal LCs. Results: After the first session, the number of lentigines was reduced only in the hand treated with cryopeeling (p 0.001) and reduced for both cryopeeling and TCA treated hands at the end of the study (p0.001, p=0.004, respectively). Cryopeeling produced significant lightening (p= 0.05) compared with TCA 35%. Blistering, hyper/hypopigmentation were reported side effects with cryopeeling, whereas only hyperpigmentation was noted after TCA peeling. The number of epidermal LCs remained at about the pretreatment number in cryopeeling treated skin (p= 0.058), though they decreased after TCA peeling compared with both untreated (p0.001) and cryopeeling treated skin (p=0.001). Conclusions: Cryopeeling provided faster and superior improvement of lentigines compared with TCA peeling. Cryopeeling seems to have little effect on LCs, in contrast to TCA peeling which might exert inhibitory effect on skin immunity through reduction of epidermal LCs, suggesting a possible tumorigenic effect of TCA.

Abstract: Background: Liver is the most injured organ in abdominal trauma. The management of blunt liver trauma has markedly changed in the last three decades with a significant improvement in outcomes, due to improvements in diagnostic and therapeutic aids. This study details incidence, grades, causes, types and management of blunt isolated liver trauma in trauma patients admitted to Assiut and South Valley University Hospitals. Patients and Methods: All patients having blunt liver trauma were admitted, history taking, laboratory investigations and resuscitation were performed simultaneously along with ultrasound and CT scan as needed. Data of mechanism trauma, grade of liver injury, method of intervention (Operative or non-operative) and outcome were collected, tabulated and analyzed. Results: Total 174 cases were included in this study with diagnosis of isolated blunt hepatic injuries, mostly young patients were involved, and their mean age was found 24.19+14.65 years. The majority of patients were males 138 (79.31%). Operative management was adopted in 39 patients (22.41%), nonoperative management adopted in 129 patients (74.13%), and 6 patients (3.45%) died during initial resuscitation. Most cases of liver trauma were found to be grade-III hepatic injury (41.1%). Chest infection was the commonest complication after surgical management. The mortality rate (12.1%) was significantly associated with severity of injury (grade IV and V). Conclusion: Non-operative management of isolated blunt liver trauma is feasible and safe in haemodynaically stable patient with grade I-III liver injury. Mortality in grades IV and V liver trauma is significantly high, so, early operative intervention is recommended in those patients.

Abstract: Background: Liver is the most injured organ in abdominal trauma. The management of blunt liver trauma has markedly changed in the last three decades with a significant improvement in outcomes, due to improvements in diagnostic and therapeutic aids. This study details incidence, grades, causes, types and management of blunt isolated liver trauma in trauma patients admitted to Assiut and South Valley University Hospitals. Patients and Methods: All patients having blunt liver trauma were admitted, history taking, laboratory investigations and resuscitation were performed simultaneously along with ultrasound and CT scan as needed. Data of mechanism trauma, grade of liver injury, method of intervention (Operative or non-operative) and outcome were collected, tabulated and analyzed. Results: Total 174 cases were included in this study with diagnosis of isolated blunt hepatic injuries, mostly young patients were involved, and their mean age was found 24.19+14.65 years. The majority of patients were males 138 (79.31%). Operative management was adopted in 39 patients (22.41%), nonoperative management adopted in 129 patients (74.13%), and 6 patients (3.45%) died during initial resuscitation. Most cases of liver trauma were found to be grade-III hepatic injury (41.1%). Chest infection was the commonest complication after surgical management. The mortality rate (12.1%) was significantly associated with severity of injury (grade IV and V). Conclusion: Non-operative management of isolated blunt liver trauma is feasible and safe in haemodynaically stable patient with grade I-III liver injury. Mortality in grades IV and V liver trauma is significantly high, so, early operative intervention is recommended in those patients.

Abstract: Background: Liver is the most injured organ in abdominal trauma. The management of blunt liver trauma has markedly changed in the last three decades with a significant improvement in outcomes, due to improvements in diagnostic and therapeutic aids. This study details incidence, grades, causes, types and management of blunt isolated liver trauma in trauma patients admitted to Assiut and South Valley University Hospitals. Patients and Methods: All patients having blunt liver trauma were admitted, history taking, laboratory investigations and resuscitation were performed simultaneously along with ultrasound and CT scan as needed. Data of mechanism trauma, grade of liver injury, method of intervention (Operative or non-operative) and outcome were collected, tabulated and analyzed. Results: Total 174 cases were included in this study with diagnosis of isolated blunt hepatic injuries, mostly young patients were involved, and their mean age was found 24.19+14.65 years. The majority of patients were males 138 (79.31%). Operative management was adopted in 39 patients (22.41%), nonoperative management adopted in 129 patients (74.13%), and 6 patients (3.45%) died during initial resuscitation. Most cases of liver trauma were found to be grade-III hepatic injury (41.1%). Chest infection was the commonest complication after surgical management. The mortality rate (12.1%) was significantly associated with severity of injury (grade IV and V). Conclusion: Non-operative management of isolated blunt liver trauma is feasible and safe in haemodynaically stable patient with grade I-III liver injury. Mortality in grades IV and V liver trauma is significantly high, so, early operative intervention is recommended in those patients.

Abstract: Background: Liver is the most injured organ in abdominal trauma. The management of blunt liver trauma has markedly changed in the last three decades with a significant improvement in outcomes, due to improvements in diagnostic and therapeutic aids. This study details incidence, grades, causes, types and management of blunt isolated liver trauma in trauma patients admitted to Assiut and South Valley University Hospitals. Patients and Methods: All patients having blunt liver trauma were admitted, history taking, laboratory investigations and resuscitation were performed simultaneously along with ultrasound and CT scan as needed. Data of mechanism trauma, grade of liver injury, method of intervention (Operative or non-operative) and outcome were collected, tabulated and analyzed. Results: Total 174 cases were included in this study with diagnosis of isolated blunt hepatic injuries, mostly young patients were involved, and their mean age was found 24.19+14.65 years. The majority of patients were males 138 (79.31%). Operative management was adopted in 39 patients (22.41%), nonoperative management adopted in 129 patients (74.13%), and 6 patients (3.45%) died during initial resuscitation. Most cases of liver trauma were found to be grade-III hepatic injury (41.1%). Chest infection was the commonest complication after surgical management. The mortality rate (12.1%) was significantly associated with severity of injury (grade IV and V). Conclusion: Non-operative management of isolated blunt liver trauma is feasible and safe in haemodynaically stable patient with grade I-III liver injury. Mortality in grades IV and V liver trauma is significantly high, so, early operative intervention is recommended in those patients.