Oxidative stress induced hyperglycemia plays a central role in the pathogenesis of diabetes and its complications in most of the tissues. In the present study the protective roles of lipoic acid and n-acetylcysteine for the treatment of oxidative stress in alloxan-induced diabetic rabbits were studied. The obtained results concluded that lipoic acid or N-acetylcystiene my be hseful for the therapy of oxidative stress associated with hyperglycemia. The beneficial action seems to result mainly from direct scavenging of ROS and restoring glutathione redox state.

Oxidative stress induced hyperglycemia plays a central role in the pathogenesis of diabetes and its complications in most of the tissues. In the present study the protective roles of lipoic acid and n-acetylcysteine for the treatment of oxidative stress in alloxan-induced diabetic rabbits were studied. The obtained results concluded that lipoic acid or N-acetylcystiene my be hseful for the therapy of oxidative stress associated with hyperglycemia. The beneficial action seems to result mainly from direct scavenging of ROS and restoring glutathione redox state.

Serum levels of TSH, T3, T4, progestrone and zinc were mesured for 25 women presenting to the Antenatal Clinic of Sohag University Hospital with emesis gravidarum during their first or early second trimesters of pregnancy. The same parameters were measured for 25 healthy pregnant women as control. Women with emesis gravidarium were significantly younger and of lower parity than the control. Serum TSH leve was significantly lower amongest the group of emesis gravidarum, but serum levels of T4 and progestrone was higher. Also, there is no significane differenc in T3 and zinc concentration. In conclusion, thyroid dysfunction as well as placental hyperactivity as evidenced by increased progestrone level may play a role in the causation of emesis gravidarum.

Endotoxemia as produced in rats by i.p. injection of LPS. in the present study, bile flow rate, biliary excretion of GSH and lysosomal glycosidases were measured. In addition to the meaurement of LPO, NO and some antioxidant enzymes activities in the liver and eythrocytes lysate. The results foud that LPS caused a sgnificant increase in AST,ALT, GGT, LPO and NO. However, bile flw rate and the biliary excretion of GSH andlysosomal glycoidases and antioxdant enzymes activiies were decreased.The study indicated that LPS induced hepatic injury in rats by increased release of ROS which is consumed endogenous antioxidant.

Endotoxemia as produced in rats by i.p. injection of LPS. in the present study, bile flow rate, biliary excretion of GSH and lysosomal glycosidases were measured. In addition to the meaurement of LPO, NO and some antioxidant enzymes activities in the liver and eythrocytes lysate. The results foud that LPS caused a sgnificant increase in AST,ALT, GGT, LPO and NO. However, bile flw rate and the biliary excretion of GSH andlysosomal glycoidases and antioxdant enzymes activiies were decreased.The study indicated that LPS induced hepatic injury in rats by increased release of ROS which is consumed endogenous antioxidant.

The experiment was designed to investigate the role of tannic acid as antioxidant in reduction of the oxidtive damage of ALCL3 in the brin of rat The obtained biochemical and histological results documentd that tannic acid has a prophylactic role in reducing the oxidaive amage in the bain tissues that caused by ALCL3 exposure for80 days in drinking water.

The experiment was designed to investigate the role of tannic acid as antioxidant in reduction of the oxidtive damage of ALCL3 in the brin of rat The obtained biochemical and histological results documentd that tannic acid has a prophylactic role in reducing the oxidaive amage in the bain tissues that caused by ALCL3 exposure for80 days in drinking water.

The experiment was designed to investigate the role of tannic acid as antioxidant in reduction of the oxidtive damage of ALCL3 in the brin of rat The obtained biochemical and histological results documentd that tannic acid has a prophylactic role in reducing the oxidaive amage in the bain tissues that caused by ALCL3 exposure for80 days in drinking water.

The experiment was designed to investigate the role of tannic acid as antioxidant in reduction of the oxidtive damage of ALCL3 in the brin of rat The obtained biochemical and histological results documentd that tannic acid has a prophylactic role in reducing the oxidaive amage in the bain tissues that caused by ALCL3 exposure for80 days in drinking water.

Pospectiv studies suggest that tea may protect against oxidative stress that induced tissue damage. A potential mechanism fr such effect y polyphenolc antioxidant tannic acid derived from tea was evaluated in tis study. Treatment of rats with ALCL3 for 80 days caused moderate toxicity on liver, kidney and splen as evidenced by increased LPO& No and a reduction of SOD,CAT, GST, GSH nd vitamin E.As well as histopathological changes.However improvement was noticed in the rats treated with tannic acid.