Oxidative stress has been proven to be involved in cisplatin (CP)-induced toxicity. The present study was
designed to evaluate the antioxidant activity of Vit C, N,N0-diphenyl-p-phenylenediamine (DPPD) and Lcysteine
against CP-induced testicular oxidative damage in rats. Our data indicated significant increases
in lipid peroxides (LPO), total peroxides and superoxide anion levels in testes of rats treated with CP
(2 mg/kg/week, for 4 weeks) that was associated with a significant reduction in the activity of the antioxidant
enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST). The
contents of glutathione (GSH), Vit E and Vit C were significantly lower in CP treated testes compared with
these of control. The co-administration of CP with DPPD or L-cysteine significantly reduced the elevation
in LPO, however the co-administration of CP with Vit C, DPPD or L-cysteine reduced the effect of CP on
superoxide anion and antioxidant enzymes and also on the antioxidants contents. The administration
of Vit C, DPPD or L-cysteine before CP injection improved the histological pictures and reduced the number
of apoptotic cells and DPPD was more efficient. In conclusion, DPPD is a potent antioxidant, against
CP-induced testicular oxidative damage, as compared with Vit C and L-cysteine

Oxidative stress has been proven to be involved in cisplatin (CP)-induced toxicity. The present study was
designed to evaluate the antioxidant activity of Vit C, N,N0-diphenyl-p-phenylenediamine (DPPD) and Lcysteine
against CP-induced testicular oxidative damage in rats. Our data indicated significant increases
in lipid peroxides (LPO), total peroxides and superoxide anion levels in testes of rats treated with CP
(2 mg/kg/week, for 4 weeks) that was associated with a significant reduction in the activity of the antioxidant
enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST). The
contents of glutathione (GSH), Vit E and Vit C were significantly lower in CP treated testes compared with
these of control. The co-administration of CP with DPPD or L-cysteine significantly reduced the elevation
in LPO, however the co-administration of CP with Vit C, DPPD or L-cysteine reduced the effect of CP on
superoxide anion and antioxidant enzymes and also on the antioxidants contents. The administration
of Vit C, DPPD or L-cysteine before CP injection improved the histological pictures and reduced the number
of apoptotic cells and DPPD was more efficient. In conclusion, DPPD is a potent antioxidant, against
CP-induced testicular oxidative damage, as compared with Vit C and L-cysteine

Oxidative stress has been proven to be involved in cisplatin (CP)-induced toxicity. The present study was
designed to evaluate the antioxidant activity of Vit C, N,N0-diphenyl-p-phenylenediamine (DPPD) and Lcysteine
against CP-induced testicular oxidative damage in rats. Our data indicated significant increases
in lipid peroxides (LPO), total peroxides and superoxide anion levels in testes of rats treated with CP
(2 mg/kg/week, for 4 weeks) that was associated with a significant reduction in the activity of the antioxidant
enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST). The
contents of glutathione (GSH), Vit E and Vit C were significantly lower in CP treated testes compared with
these of control. The co-administration of CP with DPPD or L-cysteine significantly reduced the elevation
in LPO, however the co-administration of CP with Vit C, DPPD or L-cysteine reduced the effect of CP on
superoxide anion and antioxidant enzymes and also on the antioxidants contents. The administration
of Vit C, DPPD or L-cysteine before CP injection improved the histological pictures and reduced the number
of apoptotic cells and DPPD was more efficient. In conclusion, DPPD is a potent antioxidant, against
CP-induced testicular oxidative damage, as compared with Vit C and L-cysteine

Oxidative stress has been proven to be involved in cisplatin (CP)-induced toxicity. The present study was
designed to evaluate the antioxidant activity of Vit C, N,N0-diphenyl-p-phenylenediamine (DPPD) and Lcysteine
against CP-induced testicular oxidative damage in rats. Our data indicated significant increases
in lipid peroxides (LPO), total peroxides and superoxide anion levels in testes of rats treated with CP
(2 mg/kg/week, for 4 weeks) that was associated with a significant reduction in the activity of the antioxidant
enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST). The
contents of glutathione (GSH), Vit E and Vit C were significantly lower in CP treated testes compared with
these of control. The co-administration of CP with DPPD or L-cysteine significantly reduced the elevation
in LPO, however the co-administration of CP with Vit C, DPPD or L-cysteine reduced the effect of CP on
superoxide anion and antioxidant enzymes and also on the antioxidants contents. The administration
of Vit C, DPPD or L-cysteine before CP injection improved the histological pictures and reduced the number
of apoptotic cells and DPPD was more efficient. In conclusion, DPPD is a potent antioxidant, against
CP-induced testicular oxidative damage, as compared with Vit C and L-cysteine

Oxidative stress has been proven to be involved in cisplatin (CP)-induced toxicity. The present study was
designed to evaluate the antioxidant activity of Vit C, N,N0-diphenyl-p-phenylenediamine (DPPD) and Lcysteine
against CP-induced testicular oxidative damage in rats. Our data indicated significant increases
in lipid peroxides (LPO), total peroxides and superoxide anion levels in testes of rats treated with CP
(2 mg/kg/week, for 4 weeks) that was associated with a significant reduction in the activity of the antioxidant
enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST). The
contents of glutathione (GSH), Vit E and Vit C were significantly lower in CP treated testes compared with
these of control. The co-administration of CP with DPPD or L-cysteine significantly reduced the elevation
in LPO, however the co-administration of CP with Vit C, DPPD or L-cysteine reduced the effect of CP on
superoxide anion and antioxidant enzymes and also on the antioxidants contents. The administration
of Vit C, DPPD or L-cysteine before CP injection improved the histological pictures and reduced the number
of apoptotic cells and DPPD was more efficient. In conclusion, DPPD is a potent antioxidant, against
CP-induced testicular oxidative damage, as compared with Vit C and L-cysteine

In this paper, local similarity solutions of natural convective boundary-layer flow over a
vertical semi-infinite cylinder embedded in a porous medium saturated with a nanofluid is presented.
The model used for the nanofluid incorporates the effects of buoyancy forces, Brownian motion,
thermophoresis and Lewis number. The governing partial differential equations and the corresponding
boundary conditions are reduced to ordinary differential equations with appropriate corresponding
boundary conditions. Numerical solutions of the resulting system of ordinary differential equations are
obtained and the flow and heat transfer characteristics are discussed for various values of the
governing nanofluid parameters