Reaction of 4chlorocoumarin3carbonitrile with ethyl thioglycolate and ethyl glycinate hydrochloride leads to a series of title products. Hydrazinolysis of amino thienocoumarin carboxylate afforded the hydrazi no derivative which underwent various reactions to build new heterocyclic rings containing thienocoumarin moiety. Chloro acetylation of aminoester compound afforded the chloro acetyl amino which underwent nu cleophilic substitution reactions various amines. The following treatment with formaldehyde under Mannich conditions afforded the corresponding imidazo derivatives. Reaction of chloroacetylamino with potassium thiocyanate yielded ethylpyrimidothieno coumarin sulfanylacetate which was used as a versatile precursor for synthesis of other heterocycles. On the other hand, reaction of chloro coumarin carbonitrile with hydrazine gave the aminopyrazolocoumaine which reacted with bifunctionally compounds to give the substituted py rimido derivatives. Diazotization and coupling of aminopyrazole with ethylcyanoacetate yielded ethylami notriazinopyrazolocoumarine carboxylate. Several of the compounds obtained demonstrated considerable antifungal and antibacterial activity in the in vitro test systems.

Reaction of 4chlorocoumarin3carbonitrile with ethyl thioglycolate and ethyl glycinate hydrochloride leads to a series of title products. Hydrazinolysis of amino thienocoumarin carboxylate afforded the hydrazi no derivative which underwent various reactions to build new heterocyclic rings containing thienocoumarin moiety. Chloro acetylation of aminoester compound afforded the chloro acetyl amino which underwent nu cleophilic substitution reactions various amines. The following treatment with formaldehyde under Mannich conditions afforded the corresponding imidazo derivatives. Reaction of chloroacetylamino with potassium thiocyanate yielded ethylpyrimidothieno coumarin sulfanylacetate which was used as a versatile precursor for synthesis of other heterocycles. On the other hand, reaction of chloro coumarin carbonitrile with hydrazine gave the aminopyrazolocoumaine which reacted with bifunctionally compounds to give the substituted py rimido derivatives. Diazotization and coupling of aminopyrazole with ethylcyanoacetate yielded ethylami notriazinopyrazolocoumarine carboxylate. Several of the compounds obtained demonstrated considerable antifungal and antibacterial activity in the in vitro test systems.

Reaction of 4chlorocoumarin3carbonitrile with ethyl thioglycolate and ethyl glycinate hydrochloride leads to a series of title products. Hydrazinolysis of amino thienocoumarin carboxylate afforded the hydrazi no derivative which underwent various reactions to build new heterocyclic rings containing thienocoumarin moiety. Chloro acetylation of aminoester compound afforded the chloro acetyl amino which underwent nu cleophilic substitution reactions various amines. The following treatment with formaldehyde under Mannich conditions afforded the corresponding imidazo derivatives. Reaction of chloroacetylamino with potassium thiocyanate yielded ethylpyrimidothieno coumarin sulfanylacetate which was used as a versatile precursor for synthesis of other heterocycles. On the other hand, reaction of chloro coumarin carbonitrile with hydrazine gave the aminopyrazolocoumaine which reacted with bifunctionally compounds to give the substituted py rimido derivatives. Diazotization and coupling of aminopyrazole with ethylcyanoacetate yielded ethylami notriazinopyrazolocoumarine carboxylate. Several of the compounds obtained demonstrated considerable antifungal and antibacterial activity in the in vitro test systems.

Reaction of 4chlorocoumarin3carbonitrile with ethyl thioglycolate and ethyl glycinate hydrochloride leads to a series of title products. Hydrazinolysis of amino thienocoumarin carboxylate afforded the hydrazi no derivative which underwent various reactions to build new heterocyclic rings containing thienocoumarin moiety. Chloro acetylation of aminoester compound afforded the chloro acetyl amino which underwent nu cleophilic substitution reactions various amines. The following treatment with formaldehyde under Mannich conditions afforded the corresponding imidazo derivatives. Reaction of chloroacetylamino with potassium thiocyanate yielded ethylpyrimidothieno coumarin sulfanylacetate which was used as a versatile precursor for synthesis of other heterocycles. On the other hand, reaction of chloro coumarin carbonitrile with hydrazine gave the aminopyrazolocoumaine which reacted with bifunctionally compounds to give the substituted py rimido derivatives. Diazotization and coupling of aminopyrazole with ethylcyanoacetate yielded ethylami notriazinopyrazolocoumarine carboxylate. Several of the compounds obtained demonstrated considerable antifungal and antibacterial activity in the in vitro test systems.

EWAGE sludge collected from El-Salhya sewage station at Qena ..... city in Egypt was applied in a pot experiment to investigate the uptake and distribution of certain mineral nutrients and some heavy metals in different organs of Gossypium barbadence plants. The sludge was mixed with sand at three levels: 10%, 20% and 30% and the sand was used (without sludge) as control. Results revealed that amendment the sandy soil with sewage sludge resulted in increasing the essential nutrients in the experimental plant parts especially N and P. The distribution of Na and K was in another way, and mostly Na accumulated in roots while more K transported into shoots of the plants. Results indicated also that Na/K ratio was higher in plant roots than in shoots. Mg and Ca distributed in shoots and roots with significant change from the roots toward the shoots, and also between both organs in plants grown on sludge and their analogous in control plants. Results of heavy metals analysis in this study indicated that heavy metal accumulation was more in roots than shoots under sewage sludge amendment. Data indicated that Fe and Pb accumulated in roots of plants more than shoots. In contrast to these metals, Ni was transported up to the shoots, while low amounts were detected in roots. The accumulation of heavy metals in cotton plants grown on sandy soil amended with sewage sludge was generally arranged in the following preference: Fe Zn Pb Ni which reflected the concentrations of these metals in sludge. Correlation analysis between the contents of heavy metals in both organs of cotton plants and that in the sand-sludge mixture showed different relationships.

Torrential rains (in January 1980) that had suddenly swept a limited area in the eastern desert facing Qena Province (Upper Egypt) resulted in enriching the vegetation of some extremely dry wadies at this location. Vegetation survey carried out shortly after this event (in April) revealed the prevailance of annuals which are hardly recognizable in such usually dry habitats and in considerable abundance. The normally scarce perennial vegetation has flourished too. The investigation revealed that the wadies studied are potential shelters of 3 community types, one of which seems to be a segetal part of an "Alliance" wide-spread in other wadies of this desert. Distribution of such vegetation units seems to be controlled by relative aridity of the soil as well as by soil depth.

Torrential rains (in January 1980) that had suddenly swept a limited area in the eastern desert facing Qena Province (Upper Egypt) resulted in enriching the vegetation of some extremely dry wadies at this location. Vegetation survey carried out shortly after this event (in April) revealed the prevailance of annuals which are hardly recognizable in such usually dry habitats and in considerable abundance. The normally scarce perennial vegetation has flourished too. The investigation revealed that the wadies studied are potential shelters of 3 community types, one of which seems to be a segetal part of an "Alliance" wide-spread in other wadies of this desert. Distribution of such vegetation units seems to be controlled by relative aridity of the soil as well as by soil depth.