The potential influence of nanoparticles (NPs) on the liver and bone marrow has received attention. The aim of this work was to evaluate the effect of nanocurcumin on the oxidative stress, apoptosis, and toxicity induced by Al2O3 and its NPs. The experimental animals (n = 72 mice) were divided into the following groups: group I, as a control; groups II and III, as aluminum oxide and its NPs (6 mg/kg); group IV, as aluminum oxide + nanocurcumin (Al2O3 + N-Cur, 20 mg/ kg); and group V, as aluminum oxide NPs + nanocurcumin (Al2O3-NP + N.Cur., 20 mg/kg). Al2O3 and its NP groups significantly increased p53, Nrf2 levels, and the white blood cell count. They also decreased the Hsp70 level, antitrypsin, immunoglobulin G, and the red blood cell count. In addition, they significantly decreased the total and differential bone marrow cell counts and the maturation index ratio (MIR). Nanocurcumin (N.Cur.) reverted the previous proteins, blood parameters, total bone marrow cell count, and the MIR as M/E, I/Mg, MMI, I/Me, and EMI to normal. Furthermore, N.Cur. prevented apoptosis and reduced the histopathological score and collagen fiber percentage caused by Al2O3 and its NPs in the liver. Nanotechnology was used to increase the therapeutic efficiency of curcumin against the harmful effects of oxidative stress associated with Al2O3 NPs.

Collagen-induced arthritis is the most used experimental model for rheumatoid arthritis. Using this model, we have appraised the histopathological effects of ginger and curcuma alone and their combination. Arthritis was induced by immunization with an emulsion of Freund’s adjuvant mixed with alum-precipitated collagen. Half of the animals from each group were sacrificed on the 21st day of arthritis induction and the remaining on the 26th day. Body-weight gain and erythrocyte sedimentation rate showed marked improvement in the treated groups (P < 0.001). A spectrum of intra-articular histopathological changes was assessed in groups II to V. The untreated arthritic rats in group II exhibited inflammation and vascularity in the synovium compared to the control rats in group I. The treated rats in groups III (ginger alone), IV (curcuma alone), and V (ginger and curcuma) showed an improvement of the hyperplastic synovium. These findings show that the combined use of ginger and curcuma may be a good option for the treatment of collagen-induced arthritis. This makes a case for a human clinical trial of the use of ginger and curcuma for arthritis.

The reversible addition‐fragmentation chain‐transfer (RAFT) process has become a versatile tool for the preparation of defined polymers tolerating a large variety of functional groups. Several dithioesters, trithiocarbonates, xanthates, or dithiocarbamates have been developed as effective chain transfer agents (CTAs), but only a few examples have been reported, where the resulting end groups are directly considered for a secondary use besides controlling the polymerization. Herein, it is demonstrated that β‐hydroxy dithiocinnamic esters represent a hitherto overlooked class of materials, which are originally designed for the complexation of transition metals but may as well act as reversible CTAs. Modified with a suitable leaving group (R‐group), these vinyl conjugated dithioesters indeed provide reasonable control over the polymerization of acrylates, acrylamides, or styrene via the RAFT process. Kinetic studies …

Ferrocene and its derivatives compounds have shown a significant role in medicinal organometallic chemistry as an antiparasitic or antibacterial. Therefore, we herein report on the utilization of dithioesters ferrocenyl derivatives as proligands for the synthesis of heteroleptic platinum(II) and homoleptic palladium(II) complexes bearing a conserved O,S binding moiety. The resulting complexes [Pt(L1)(DMSO)Cl] (1), [Pt(L2)(DMSO)Cl] (2), [Pt(L3)(DMSO)Cl] (3), [Pd(L1)₂] (4), [Pd(L2)₂] (5), and [Pd(L3)₂] (6), in which HL1 = methyl 3-hydroxy-3-ferroceneprop-2-enedithioate, HL2 = ethyl 3-hydroxy-3-ferroceneprop-2-enedithioate and HL3 = propyl 3-hydroxy-3-ferroceneprop-2-enedithioate, were fully characterized employing a variety of analytical techniques (NMR spectroscopy, elemental analysis, and mass spectrometry and X-ray structure determination of complexes 2 and 6). Cytotoxicity assays of the synthesized

Due to the uniqueness and the variation of the ionic radius and oxidation states of the implanted transition metals within nano ferrites structure, The nano ferrites are integrated into many technologies including biomedical application the current study aims to optimize the effect of cerium-dopant on the magnetic behavior and antimicrobial properties of manganese nano ferrites. Cerium-doped manganese nano ferrites are synthesized by chemical co-precipitation method followed by thermal annealing at 500 °C. and investigate the dopant effects on its magnetic behavior and antibacterial properties for biomedical applications. The cubic spinel ferrite is successfully formed and CeO₂ and Fe₂O₃ have appeared as minor phases. The particle size is found to be 20–60 nm. The Ce_0.05Mn_0.95Fe₂O₄ nano ferrite exhibits the highest saturation magnetization of about 20.47 emu/g with 118.22 Oe as coercivity. EPR factors were affected due to crystalline anisotropy that appeared inside the Ce_xMn_X-1Fe₂O₄ spinel ferrites nanomaterials. In comparison to chloramphenicol, cerium nanoparticles exhibited promising inhibitory action against six pathogenic bacteria (Bacillus cereus, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Klebsiella pneumoniae, and Serratia plymuthica). All cerium treatments showed suitable antibacterial activities. However, the treatments of X = 0.000, X = 0.025, and X = 0.050 were the most effective. For Gram-negative bacteria, the best treatment was X = 0.025, while for Gram-positive isolates, the best treatment was X = 0.050 with MIC 5–10 µg/ml. Our finding, open the pathway to integrate cerium doped manganese nano ferrites in biomedical application including against human pathogenic bacteria.

Herein, the presented approach was investigated a unique technique for manufacturing water repellent/UV-protective cotton fabrics through in-situ/thermal polymerization of benzoxazine (BZs) within cotton matrix. Two BZs abbreviated as Ph-p-BZ and Ph-o-BZ were initially synthesized, and their chemical formulas were verified with FTIR, ¹HNMR, and ¹³CNMR spectral mapping data. For Ph-p-BZ, the endothermic peak was observed at 65 ᵒC, to indicate its highly/purified crystalline structure. DSC data for poly-(Ph-p-BZ) and poly-(Ph-o-BZ) showed that, their high Tg was estimated at 210 ᵒC and 195 ᵒC, respectively, due to their highly crystalline/cross-linked network structure. In-situ/thermal polymerization of Ph-p-BZ and Ph-o-BZ as within cotton matrix was subsequently proceeded. Contact angle was observably increased to 125.0° for the fabric coated with four layers of poly-(Ph-p-BZ) (cotton modified with four …

In this work, a new and effective polymeric coating is used to improve mild steel's corrosion resistance. The coating incorporates a Schiff base moiety into a benzoxazine (BZ) precursor, resulting in improved protection against corrosion. The SF-Tol-BZ polymerization behavior and thermal properties were studied using differential scanning calorimetry (DSC) and thermalgravimetric analysis (TGA), respectively, at different curing temperatures. The poly(SF-Tol-BZ) cured at 240 °C had a T_d10 value of 604 °C and a Tg of 225 °C. The efficacy of poly(SF-Tol-BZ) coatings in protecting mild steel (MS) from corrosion in a NaCl (3.5%) solution at room temperature was evaluated using various corrosion measurements, including open circuit potential (OCP), and electrochemical impedance spectroscopy (EIS). The results showed that increasing the poly(SF-Tol-BZ) concentration led to a corresponding increase in its protective …