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The regioselective synthesis of cis and trans stereoisomers of variously functionalized octahydro[1,2,4]triazolo[4,3-a]quinazolin-5-ones was performed. The 2-thioxopyrimidin-4-ones used in the synthesis reacted with hydrazonoyl chlorides in a regioselective manner to produce the angular regioisomers [1,2,4]triazolo[4,3-a]quinazolin-5-ones rather than the linear isomers [1,2,4]triazolo[4,3-a]quinazolin-5-ones. The synthesis process took place with electronic control. The angular regiochemistry of the products was confirmed by X-ray experiments and two-dimensional NMR studies.

The North Western Sahara Aquifer System (NWSAS) is characterized by unsustainable groundwater exploitation whose magnitude depends on the still unclear recharge value. It is extending over Libya, Tunisia, and Algeria, with an area of 10⁶ km². Here, we propose an integrated approach combining Gravity Recovery and Climate Experiment (GRACE) and Global Land Data Assimilation System (GLDAS) data to reconstruct groundwater storage variations (ΔGWS) between April 2002 and July 2016. ΔGWS values are then introduced in a regional water budget equation accounting for the temporal evolution of withdrawals and natural discharge to calculate the time variations of the recharge. Yearly reconstruction of the recharge shows a large variability with alternation of net positive recharge and periods of net diffuse discharge associated with evaporation. The temporal average effective recharge value for the period of interest is 1.76±0.44 mm yr⁻¹. Lag-times for the recharge to reach the water table of 45 and 100 yrs characteristic of a diffuse recharge and corresponding vadose thickness in the range 3.90±3.60 and 8.60±8.10 meters were identified using a cross-correlation analysis between reconstructed annual recharge and annual rainfall (AR). Statistical interpretation of the relation between ΔGWS, AR, and withdrawals shows that the anthropogenic effect (groundwater extraction) is the main controlling factor (99% of explained variance) in comparison to AR variations for the ΔGWS time series under consideration. A relation between long-term recharge and average annual rainfall (AAR) suggests a recharge representing 1.8±0.3% of AAR in transboundary aquifers of the Saharan belt.

A sensitive method for diagnosing coronavirus disease 2019 (COVID-19) is highly required to fight the current and future global health threats due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2). However, most of the current methods exhibited high false‐negative rates, resulting in patient misdiagnosis and impeding early treatment. Nanoparticles show promising performance and great potential to serve as a platform for diagnosing viral infection in a short time and with high sensitivity. This review highlighted the potential of nanoparticles as platforms for the diagnosis of COVID-19. Nanoparticles such as gold nanoparticles, magnetic nanoparticles, and graphene (G) were applied to detect SARS-CoV 2. They have been used for molecular-based diagnosis methods and serological methods. Nanoparticles improved specificity and shorten the time required for the diagnosis. They may be implemented into small devices that facilitate the self-diagnosis at home or in places such as airports and shops. Nanoparticles-based methods can be used for the analysis of virus-contaminated samples from a patient, surface, and air. The advantages and challenges were discussed to introduce useful information for designing a sensitive, fast, and low-cost diagnostic method. This review aims to present a helpful survey for the lesson learned from handling this outbreak to prepare ourself for future pandemic.