Because of its unique properties, zinc is widely used in many industries, including medical devices, electronics, and automotive components, but it is susceptible to corrosion, especially in salty environments. In this context, the inhibitory efficacy of two environmentally friendly expired drugs, gatifloxacin (Gat) and levofloxacin (Lev), on zinc corrosion in 3.5 % NaCl solution was investigated using several techniques at different temperatures. Kinetic and thermodynamic evaluations confirmed that the adsorption strength of these compounds on the metal surface plays an effective role in their inhibitory capacity, and this certainly depends on their chemical structure. The inhibition efficiencies (% IEs) were calculated to be 87 % and 89 % for Gat and Lev using 500 mg/L of drug and at 298 K, respectively. Potentiodynamic polarization (PDP) studies have classified these drugs as anodic-type inhibitors. Adsorption assessments have shown that it is a physical process following the Langmuir isotherm. Electrochemical impedance spectroscopy (EIS) experiments have demonstrated good adhesion and stability of the protective film on the metal surface resulting from the adsorption of these compounds. Inhibition mechanisms have also been provided. Response surface methodology (RSM) analysis was used to analyze the data and predict the response. The experimental results of all the techniques used and the statistical and computational analysis were in remarkable agreement with each other.

: Inclinedsquarecavitiesplayacritical role inengineeringapplications,partic ularlyinthermalmanagement,energystorageandelectroniccooling,whereinclinationangles in°uence convectiveheat transfer.This studyexamines conjugate convectiveheat transfer withinaninclinedsquarecavity¯lledwithmicropolarnano°uidsunderatiltedLorentzforce usinga two-phasenano°uidmodel.The systemincludes aheat-generatingporousmedium underthermalnonequilibrium, introducingcomplexdynamics.Factorssuchasthermalbuoy ancy,°uid{solidheattransfercoe±cientandmicropolar°uidpropertiesareanalyzedfortheir impact onheat transfer e±ciency.Methods:The studyuses the¯nitedi®erencemethod (FDM) to solvenonlinear equations governingconvective°owandheat transfer.Physical parameters,includingthermalbuoyancy,micropolarpropertiesandthicknessofthesolidwalls,

A multistep synthesis of novel pyrene-based thiazole moiety been has been realized following some synthetic challenges and complications. The chemical structure of the synthesized compound has been established on the basis of both spectroscopic and analytical tools. Its nucleophilic reactivity with 4,6-dinitrobenzofuroxan (DNBF) has been successfully studied in solution. A kinetic study of the covalent electrophile/nucleophile combination of dinitrobenzofuroxan (DNBF, electrophile) and 4-(pyren-1-yl)thiazol-2-amine (nucleophile) resulting in the formation of the corresponding σ-adduct in solution is reported. The rate constant (k₁) of the second-order relating to the CC bond forming step of this complexation process has been found to fit into the linear correlation log k = s_N (N + E), thereby permitting the evaluation of the nucleophilicity parameter (N) of the 4-(pyren-1-yl)thiazol-2-amine. 4-(Pyren-1-yl)thiazol-2-amine has been subsequently ranked according to its reactivity profile on the general nucleophilicity scale developed recently by Mayr et al., leading to an interesting and direct comparison over a large domain of π-, σ-, and n-nucleophiles.

Nowadays, the growth of drug-resistant microbial strains (MDRs) is a serious public health threat worldwide. Moreover, tens of millions of people are annually diagnosed with cancer worldwide, and more than half of patients ultimately die. In the present study, a new series of 2-(4-substituted-thiazol-2-ylamino)acetamides and N-(4-substituted-thiazol-2-yl)acetamides incorporating sulfonamide moieties were designed, synthesized, well-characterized and successfully evaluated for their antimicrobial activity against multidrug resistant strains and screened for cytotoxic activity against normal lung fibroblast (WI-38), human lung carcinoma (A549), and human breast carcinoma (MDA-MB-231) cell lines. Fluorescence-activated cell sorting (FACS) analysis and molecular modeling study were performed to identify the mode of action of the novel synthesized compounds and their binding interactions with the active sites of dihydrofolate reductase enzyme (DHFR).

In this study, a new series of (4-(2,7-dichloro-9H-fluoren-4-yl)thiazol-yl)acetamide derivatives was synthesized, and the new heterocycles were completely characterized, evaluated for their antimicrobial activity, and screened for cytotoxic activity against human lung carcinoma (A-549) and human breast carcinoma (MCF-7) cell lines. A molecular docking study was undertaken to identify the possible mode of action of the synthesized compounds, which suggested binding interactions with the dihydrofolate reductase (DHFR) active sites.

Most of the synthesized compounds displayed meaningful activity against A-549 and MCF-7 cell lines when compared to 5-fluorouracil (5-FU), which was used as a reference drug. Furthermore, some of the prepared compounds exhibited potent antibacterial and antifungal activities. The highly pronounced biological activities of the compounds under investigation offer such species as promising future drug prospects which may find applications in the fields of biological and medicinal sciences.