The acute phase response to chemically-induced organ damage involves inflammation and the production of LTs.The liver ordinarily takes up metabolites and excretes into bile cysteinyl LTs, but the effect of hepatic injury on theses processes is unknown. The hepatic uptake and biliary excretion of LTC4 was studied in male rats after exposure to eiter STZ, estadiol, or LPS/galactosamine respectively. Biliry excetion of 3H-LTC4 was similar to normal control rats in three models of acute liver injury.

LPS and STZ induced-diabetes are known to cause oxidative stress in vivo. Female rats were given STZ (50mg/kg, i.p. once) prior to exposure to either LPS (5 mg/kg body weight) or 3 daily doses of STZ). One week after LPS or STZ treatment, oxidative stress was determined by measuring changes in antioxidant enzyme activities (GPx, GR, SOD, CAT, GST& GGT)and GSH content. In addition, to measureing LPO and NO in liver, kidney, intestine and spleen tissues. The obtained results suggests that STZ, like LPS may confer a protective effect against subsequent oxidative stress.

Galactosamin plus endotoxin has been used widely as model of hepatitis. But the acute effect of this combination on hepatic and extrahepatic biotransformation has not been determined. Therefore, either 2 or 4 hr after a single i.p. dose of 300 mg/kg galactosamine plus 30 ug/kg LPS was administered. Serum, liver, kidney, intestine and spleen were collected. Serum enzymes (AST, ALT,SDH & GGT) were elevated dramatically 2 or 4 hr after treatment. Cytochrome P450 activity toward benzo[a]pyrene was increased in kidney 4 hr after tratment, wheras dealkylation of 7-methoxycoumarin or 7-ethoxresorufin was unchanged in any tisuue at either time point. An increase in UDP-glucuronsyltransferase activity toward 4-methylumbelliferone and 4-hydroxbiphenyl was noted in the intestine. Conjugation of CDNB with GSH was increased in intestine and spleen after 4 hr treatment. GSH content was increased by different amounts depending on which organs were studied 2 or 4 hr after treatment

The effect of in vivo exposure to roridin E alone and in combination with linoleic acid on rats was studied. Treatment of rats with a sublethal dose of roridin (2 mg/kg body weight) alone did not caused an significant effect on most studied biochemical parameters in liver and kidney tissues and plasma. However, co-administration of linoleic acid with roridin E resulted in increasing its toxicity as evidenced by the the biochemical changes.

The effect of in vivo exposure to roridin E alone and in combination with linoleic acid on rats was studied. Treatment of rats with a sublethal dose of roridin (2 mg/kg body weight) alone did not caused an significant effect on most studied biochemical parameters in liver and kidney tissues and plasma. However, co-administration of linoleic acid with roridin E resulted in increasing its toxicity as evidenced by the the biochemical changes.

The present study aimed to investigate the hiso-morphological appearance and some biochemial changes of CL in relation to its functional activity during the estrous cycle and early pregnancy in buffalo- cows. The obtained results indicated the presence of two morphologically distinct steriogenic cells. There was a relationship between the average surface area of lueal component, the fine structure of luteal cells and serum progestron at different luteal phases and at early pregnancy. Changes in LPO, NO and SOD activity, played a significant role in regulation of CL function.

The present study aimed to investigate the hiso-morphological appearance and some biochemial changes of CL in relation to its functional activity during the estrous cycle and early pregnancy in buffalo- cows. The obtained results indicated the presence of two morphologically distinct steriogenic cells. There was a relationship between the average surface area of lueal component, the fine structure of luteal cells and serum progestron at different luteal phases and at early pregnancy. Changes in LPO, NO and SOD activity, played a significant role in regulation of CL function.

The present study aimed to investigate the hiso-morphological appearance and some biochemial changes of CL in relation to its functional activity during the estrous cycle and early pregnancy in buffalo- cows. The obtained results indicated the presence of two morphologically distinct steriogenic cells. There was a relationship between the average surface area of lueal component, the fine structure of luteal cells and serum progestron at different luteal phases and at early pregnancy. Changes in LPO, NO and SOD activity, played a significant role in regulation of CL function.

The tropical parasite Schistoma mansoni causes granulomatous inflammation after its eggs lodge in hepatic portal capillaries. The role of melatonin as antioxidants inprotection against oxidative stress in mice infected with S. mansoni was investigated. The results suggest that oxidative processes occur at the site of inflammation and are involved in the damaging effects of Schistomasiasis.Also, melatonin, due to its free radical scavenging activity, is highly protective against the pathological changes associated with Schistomasiasis.

The tropical parasite Schistoma mansoni causes granulomatous inflammation after its eggs lodge in hepatic portal capillaries. The role of melatonin as antioxidants inprotection against oxidative stress in mice infected with S. mansoni was investigated. The results suggest that oxidative processes occur at the site of inflammation and are involved in the damaging effects of Schistomasiasis.Also, melatonin, due to its free radical scavenging activity, is highly protective against the pathological changes associated with Schistomasiasis.