Indan-1,3-dione (1) reacted with 3-dicyanomethylidene-2-oxoindolines (2a-c) in refluxed ethanol to afford 2-amino-3-cyanospiro{5H-indeno[1,2-b] pyrane-4,3'-(1’-substitutedindoline)}-2’,5-diones (3a-c) which underwent different reactions to afford new spiro{indeno[2',1':5,6] pyrano[2,3-d]pyrimidine- 5,3'-(1’-substitutedindoline)} (4a,b)-(12a,b) which are analogues of some reported biologically active spiropolycyclic compounds.

Indan-1,3-dione (1) reacted with 3-dicyanomethylidene-2-oxoindolines (2a-c) in refluxed ethanol to afford 2-amino-3-cyanospiro{5H-indeno[1,2-b] pyrane-4,3'-(1’-substitutedindoline)}-2’,5-diones (3a-c) which underwent different reactions to afford new spiro{indeno[2',1':5,6] pyrano[2,3-d]pyrimidine- 5,3'-(1’-substitutedindoline)} (4a,b)-(12a,b) which are analogues of some reported biologically active spiropolycyclic compounds.

Indan-1,3-dione (1) reacted with 3-dicyanomethylidene-2-oxoindolines (2a-c) in refluxed ethanol to afford 2-amino-3-cyanospiro{5H-indeno[1,2-b] pyrane-4,3'-(1’-substitutedindoline)}-2’,5-diones (3a-c) which underwent different reactions to afford new spiro{indeno[2',1':5,6] pyrano[2,3-d]pyrimidine- 5,3'-(1’-substitutedindoline)} (4a,b)-(12a,b) which are analogues of some reported biologically active spiropolycyclic compounds.

Indan-1,3-dione (1) reacted with 3-dicyanomethylidene-2-oxoindolines (2a-c) in refluxed ethanol to afford 2-amino-3-cyanospiro{5H-indeno[1,2-b] pyrane-4,3'-(1’-substitutedindoline)}-2’,5-diones (3a-c) which underwent different reactions to afford new spiro{indeno[2',1':5,6] pyrano[2,3-d]pyrimidine- 5,3'-(1’-substitutedindoline)} (4a,b)-(12a,b) which are analogues of some reported biologically active spiropolycyclic compounds.

2-Methylimidazole (1) reacted with 3-dicyanomethylidine-1-ethyl-2-oxoindoline (2) in ethyl acetate to afford 5-amino-6-cyano-7,8-dihydro-1'-ethylspiro{imidazo[1,2-a]pyridine-7,3'-indolin}-2'-one (8), which used as a key intermediate for the synthesis of fused spiroheterocyclic derivatives of imidazo- pyridopyrimidine and/or imidazonaphthyridine nucleus incorporated indoline moiety. The chemical structures of all synthesized compounds were elucidated by the elemental and spectroscopic analyses.

2-Methylimidazole (1) reacted with 3-dicyanomethylidine-1-ethyl-2-oxoindoline (2) in ethyl acetate to afford 5-amino-6-cyano-7,8-dihydro-1'-ethylspiro{imidazo[1,2-a]pyridine-7,3'-indolin}-2'-one (8), which used as a key intermediate for the synthesis of fused spiroheterocyclic derivatives of imidazo- pyridopyrimidine and/or imidazonaphthyridine nucleus incorporated indoline moiety. The chemical structures of all synthesized compounds were elucidated by the elemental and spectroscopic analyses.

2-Methylimidazole (1) reacted with 3-dicyanomethylidine-1-ethyl-2-oxoindoline (2) in ethyl acetate to afford 5-amino-6-cyano-7,8-dihydro-1'-ethylspiro{imidazo[1,2-a]pyridine-7,3'-indolin}-2'-one (8), which used as a key intermediate for the synthesis of fused spiroheterocyclic derivatives of imidazo- pyridopyrimidine and/or imidazonaphthyridine nucleus incorporated indoline moiety. The chemical structures of all synthesized compounds were elucidated by the elemental and spectroscopic analyses.

2-Methylbenzimidazole 1 reacted with 3-dicyanomethylidine- 1-ethyl-2-oxoindoline 2 in ethyl acetate to afford 1-amino-2-cyano-3,4-dihydro-10-ethylspiro{benzimidazo[ 1,2-a]pyridine-3,30-indolin}-20-one 6, which was used as a key intermediate in the synthesis of fused spiropolyheterocyclic derivatives of benzimidazopyridopyrimidine and/or benzimidazonaphthyridine nucleus incorporating an indoline moiety