2-Methylbenzimidazole 1 reacted with 3-dicyanomethylidine- 1-ethyl-2-oxoindoline 2 in ethyl acetate to afford 1-amino-2-cyano-3,4-dihydro-10-ethylspiro{benzimidazo[ 1,2-a]pyridine-3,30-indolin}-20-one 6, which was used as a key intermediate in the synthesis of fused spiropolyheterocyclic derivatives of benzimidazopyridopyrimidine and/or benzimidazonaphthyridine nucleus incorporating an indoline moiety

2-Methylbenzimidazole 1 reacted with 3-dicyanomethylidine- 1-ethyl-2-oxoindoline 2 in ethyl acetate to afford 1-amino-2-cyano-3,4-dihydro-10-ethylspiro{benzimidazo[ 1,2-a]pyridine-3,30-indolin}-20-one 6, which was used as a key intermediate in the synthesis of fused spiropolyheterocyclic derivatives of benzimidazopyridopyrimidine and/or benzimidazonaphthyridine nucleus incorporating an indoline moiety

Novel dispiro[pyrazolidine-4,3'-pyrrolidine-2',3"-indoline]-2",3,5-triones 5a-j were obtained regioselectively by 1,3-dipolar cycloaddition reaction of 4-arylidene-1-phenylpyrazolidine-3,5- diones 2a-e as dipolarophiles with non-stabilized azomethine ylides, generated in situ via decarboxylative condensation of isatins 3a,b and sarcosine 4 in dry ethanol. The prepared compounds were screened for their anti-inflammatory activity "at a dose of 10 mg/kg body weight", especially 5d, 5f, 5h, and 5j which reveal remarkable activities relative to indomethacin which was used as a reference standard in this study.

Novel dispiro[pyrazolidine-4,3'-pyrrolidine-2',3"-indoline]-2",3,5-triones 5a-j were obtained regioselectively by 1,3-dipolar cycloaddition reaction of 4-arylidene-1-phenylpyrazolidine-3,5- diones 2a-e as dipolarophiles with non-stabilized azomethine ylides, generated in situ via decarboxylative condensation of isatins 3a,b and sarcosine 4 in dry ethanol. The prepared compounds were screened for their anti-inflammatory activity "at a dose of 10 mg/kg body weight", especially 5d, 5f, 5h, and 5j which reveal remarkable activities relative to indomethacin which was used as a reference standard in this study.

3-dicyanomethylidine-2-oxoindolines 1a-c reacted with different cyclic carbonyl compounds to afford new spiroheterocyclic derivatives 2a-c to 5a-c which are analogues of some reported biologically active spiropolycyclic compounds.

3-dicyanomethylidine-2-oxoindolines 1a-c reacted with different cyclic carbonyl compounds to afford new spiroheterocyclic derivatives 2a-c to 5a-c which are analogues of some reported biologically active spiropolycyclic compounds.

3-dicyanomethylidine-2-oxoindolines 1a-c reacted with different cyclic carbonyl compounds to afford new spiroheterocyclic derivatives 2a-c to 5a-c which are analogues of some reported biologically active spiropolycyclic compounds.

3-dicyanomethylidine-2-oxoindolines 1a-c reacted with different cyclic carbonyl compounds to afford new spiroheterocyclic derivatives 2a-c to 5a-c which are analogues of some reported biologically active spiropolycyclic compounds.

2-Naphthol reacted with 3-dicyanomethylidine-1-ethyl-2-oxoindoline in absolute ethanol to afford 2-Amino-3-cyano-1'-ethylspiro{benzo[f]chromen-4,3'-indolin}-2'-one, which used as key intermediate to synthesis fused spiropolyheterocyclic derivatives of pyrimido- benzochromen and/or pyridobenzochromen nucleus incorporated indoline moiety.

2-Naphthol reacted with 3-dicyanomethylidine-1-ethyl-2-oxoindoline in absolute ethanol to afford 2-Amino-3-cyano-1'-ethylspiro{benzo[f]chromen-4,3'-indolin}-2'-one, which used as key intermediate to synthesis fused spiropolyheterocyclic derivatives of pyrimido- benzochromen and/or pyridobenzochromen nucleus incorporated indoline moiety.