A highly stable ternary complex of iron(III) with 5-(4-nitrophenylazo) salicylic acid (NPAS) and Eosin (Es) in acidic medium at room temperature gave a maximum absorption at 545 nm with a molar absorptivity 2.81×104 L mol−1 cm−1. A spectrophotometric method using these ligands was developed and optimized in terms of pH, stability of the complex, amount of reagent required, sensitivity, linearity, and the effect of various foreign ions was studied. The linear range for iron(III) determination is 0.18–6.0 mg L−1. The method was sensitive, accurate, and all the reagents were stable under the working conditions. Moreover, the method was easy to perform for the determination of iron in pharmaceutical and water samples.

A highly sensitive method is proposed to determine copper(II) ions by forming a stable complex through their interaction with 4-(2′-benzothiazolylazo)-salicylic acid (BTAS) at room temperature and pH of about 5.0. The complex gave a maximum absorption at λ = 485 nm with a molar absorptivity coefficient of 2.35⋅104 l/(mol⋅cm). The linear range for the copper determination is 0.63–5.04 mg/l. The method can be applied to determine copper ions in different biological specimens like some drugs and water samples.

Cisplatin (CP) is considered as a major antineoplastic drug against a broad spectrum of malignancies. CP acts on cancer cells by releasing free radicals which at the same time damage liver and kidney cells. In this study, we aimed to investigate the hepatotoxicity of CP which it may be mediated by oxidative stress and to establish whether some antioxidants, Vit C, DPPD and L-cystiene, may provide protection against CP hepatotoxicity. 40 rats were divided into 5 groups. G1 work as control, G2 injected with CP alone, G3 was injected with CP & Vit C, G4 was injected with CP& DPPD, G5 was injected with CP & L-cystiene. CP-induced oxidative stress was indicated by ↑ LPO and O2- in hepatic tissue and plasma. Also, CP induced decline of SOD, CAT, GST and GGT and a ↓ level of GSH, Vit C and Vit E in hepatic tissue and plasma. Treatment with Vit C, DPPD and L-cysteine in combination with CP restored LPO and O2-, the activities of SOD, GST, CAT and GGT and the content of GSH, Vit C and Vit E to control levels

Cisplatin (CP) is considered as a major antineoplastic drug against a broad spectrum of malignancies. CP acts on cancer cells by releasing free radicals which at the same time damage liver and kidney cells. In this study, we aimed to investigate the hepatotoxicity of CP which it may be mediated by oxidative stress and to establish whether some antioxidants, Vit C, DPPD and L-cystiene, may provide protection against CP hepatotoxicity. 40 rats were divided into 5 groups. G1 work as control, G2 injected with CP alone, G3 was injected with CP & Vit C, G4 was injected with CP& DPPD, G5 was injected with CP & L-cystiene. CP-induced oxidative stress was indicated by ↑ LPO and O2- in hepatic tissue and plasma. Also, CP induced decline of SOD, CAT, GST and GGT and a ↓ level of GSH, Vit C and Vit E in hepatic tissue and plasma. Treatment with Vit C, DPPD and L-cysteine in combination with CP restored LPO and O2-, the activities of SOD, GST, CAT and GGT and the content of GSH, Vit C and Vit E to control levels

Cisplatin (CP) is considered as a major antineoplastic drug against a broad spectrum of malignancies. CP acts on cancer cells by releasing free radicals which at the same time damage liver and kidney cells. In this study, we aimed to investigate the hepatotoxicity of CP which it may be mediated by oxidative stress and to establish whether some antioxidants, Vit C, DPPD and L-cystiene, may provide protection against CP hepatotoxicity. 40 rats were divided into 5 groups. G1 work as control, G2 injected with CP alone, G3 was injected with CP & Vit C, G4 was injected with CP& DPPD, G5 was injected with CP & L-cystiene. CP-induced oxidative stress was indicated by ↑ LPO and O2- in hepatic tissue and plasma. Also, CP induced decline of SOD, CAT, GST and GGT and a ↓ level of GSH, Vit C and Vit E in hepatic tissue and plasma. Treatment with Vit C, DPPD and L-cysteine in combination with CP restored LPO and O2-, the activities of SOD, GST, CAT and GGT and the content of GSH, Vit C and Vit E to control levels

Cisplatin (CP) is considered as a major antineoplastic drug against a broad spectrum of malignancies. CP acts on cancer cells by releasing free radicals which at the same time damage liver and kidney cells. In this study, we aimed to investigate the hepatotoxicity of CP which it may be mediated by oxidative stress and to establish whether some antioxidants, Vit C, DPPD and L-cystiene, may provide protection against CP hepatotoxicity. 40 rats were divided into 5 groups. G1 work as control, G2 injected with CP alone, G3 was injected with CP & Vit C, G4 was injected with CP& DPPD, G5 was injected with CP & L-cystiene. CP-induced oxidative stress was indicated by ↑ LPO and O2- in hepatic tissue and plasma. Also, CP induced decline of SOD, CAT, GST and GGT and a ↓ level of GSH, Vit C and Vit E in hepatic tissue and plasma. Treatment with Vit C, DPPD and L-cysteine in combination with CP restored LPO and O2-, the activities of SOD, GST, CAT and GGT and the content of GSH, Vit C and Vit E to control levels

Fundamental (lattice, rotational, and intermolecular) vibrations of the H2AsO−4 anion in (C6H9N2)H2AsO4 crystal are calculated using the correlation theorem based on the group theory. The correlation between anionic site of symmetry Cs and the factor group D2h of the crystal yields 12 modes for both lattice and rotational vibrations. The infrared and Raman spectra of these modes do not coincide. Addition of two hydrogen atoms to AsO−4 ion yields two As—OH bonds in the H2AsO−4 anion. As a result, the molecular symmetry is reduced from Td to C2v. The free H2AsO−4 anion having C2v symmetry gives in total 15 fundamental normal vibrations. Under the crystal field splitting effects, the number of intermolecular vibrations for the anion in infrared and Raman spectra is calculated to be 56 active vibrations. The calculated fundamental vibrations manifest themselves as the main features in an experimental infrared spectrum.