2-Methylimidazole (1) reacted with 3-dicyanomethylidine-1-ethyl-2-oxoindoline (2) in ethyl acetate to afford 5-amino-6-cyano-7,8-dihydro-1'-ethylspiro{imidazo[1,2-a]pyridine-7,3'-indolin}-2'-one (8), which used as a key intermediate for the synthesis of fused spiroheterocyclic derivatives of imidazo- pyridopyrimidine and/or imidazonaphthyridine nucleus incorporated indoline moiety. The chemical structures of all synthesized compounds were elucidated by the elemental and spectroscopic analyses.

2-Methylimidazole (1) reacted with 3-dicyanomethylidine-1-ethyl-2-oxoindoline (2) in ethyl acetate to afford 5-amino-6-cyano-7,8-dihydro-1'-ethylspiro{imidazo[1,2-a]pyridine-7,3'-indolin}-2'-one (8), which used as a key intermediate for the synthesis of fused spiroheterocyclic derivatives of imidazo- pyridopyrimidine and/or imidazonaphthyridine nucleus incorporated indoline moiety. The chemical structures of all synthesized compounds were elucidated by the elemental and spectroscopic analyses.

2-Methylimidazole (1) reacted with 3-dicyanomethylidine-1-ethyl-2-oxoindoline (2) in ethyl acetate to afford 5-amino-6-cyano-7,8-dihydro-1'-ethylspiro{imidazo[1,2-a]pyridine-7,3'-indolin}-2'-one (8), which used as a key intermediate for the synthesis of fused spiroheterocyclic derivatives of imidazo- pyridopyrimidine and/or imidazonaphthyridine nucleus incorporated indoline moiety. The chemical structures of all synthesized compounds were elucidated by the elemental and spectroscopic analyses.

2-Methylbenzimidazole 1 reacted with 3-dicyanomethylidine-
1-ethyl-2-oxoindoline 2 in ethyl acetate to
afford 1-amino-2-cyano-3,4-dihydro-10-ethylspiro{benzimidazo[
1,2-a]pyridine-3,30-indolin}-20-one 6, which was
used as a key intermediate in the synthesis of fused
spiropolyheterocyclic derivatives of benzimidazopyridopyrimidine
and/or benzimidazonaphthyridine nucleus
incorporating an indoline moiety

2-Methylbenzimidazole 1 reacted with 3-dicyanomethylidine-
1-ethyl-2-oxoindoline 2 in ethyl acetate to
afford 1-amino-2-cyano-3,4-dihydro-10-ethylspiro{benzimidazo[
1,2-a]pyridine-3,30-indolin}-20-one 6, which was
used as a key intermediate in the synthesis of fused
spiropolyheterocyclic derivatives of benzimidazopyridopyrimidine
and/or benzimidazonaphthyridine nucleus
incorporating an indoline moiety

2-Methylbenzimidazole 1 reacted with 3-dicyanomethylidine-
1-ethyl-2-oxoindoline 2 in ethyl acetate to
afford 1-amino-2-cyano-3,4-dihydro-10-ethylspiro{benzimidazo[
1,2-a]pyridine-3,30-indolin}-20-one 6, which was
used as a key intermediate in the synthesis of fused
spiropolyheterocyclic derivatives of benzimidazopyridopyrimidine
and/or benzimidazonaphthyridine nucleus
incorporating an indoline moiety

Novel dispiro[pyrazolidine-4,3'-pyrrolidine-2',3"-indoline]-2",3,5-triones 5a-j were obtained regioselectively by 1,3-dipolar cycloaddition reaction of 4-arylidene-1-phenylpyrazolidine-3,5-
diones 2a-e as dipolarophiles with non-stabilized azomethine ylides, generated in situ via decarboxylative condensation of isatins 3a,b and sarcosine 4 in dry ethanol. The prepared compounds were screened for their anti-inflammatory activity "at a dose of 10 mg/kg body weight", especially 5d, 5f, 5h, and 5j which reveal remarkable activities relative to indomethacin which was used as a reference standard in this study.

Novel dispiro[pyrazolidine-4,3'-pyrrolidine-2',3"-indoline]-2",3,5-triones 5a-j were obtained regioselectively by 1,3-dipolar cycloaddition reaction of 4-arylidene-1-phenylpyrazolidine-3,5-
diones 2a-e as dipolarophiles with non-stabilized azomethine ylides, generated in situ via decarboxylative condensation of isatins 3a,b and sarcosine 4 in dry ethanol. The prepared compounds were screened for their anti-inflammatory activity "at a dose of 10 mg/kg body weight", especially 5d, 5f, 5h, and 5j which reveal remarkable activities relative to indomethacin which was used as a reference standard in this study.

3-dicyanomethylidine-2-oxoindolines 1a-c reacted with different cyclic carbonyl compounds to afford new spiroheterocyclic derivatives 2a-c to 5a-c which are analogues of some reported biologically active spiropolycyclic compounds.

3-dicyanomethylidine-2-oxoindolines 1a-c reacted with different cyclic carbonyl compounds to afford new spiroheterocyclic derivatives 2a-c to 5a-c which are analogues of some reported biologically active spiropolycyclic compounds.