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The Faculty of Pharmacy extends its congratulations to Prof. Dr. Gihan Nabil Hassan Fetih on the occasion of the presidential decree and her appointment as Dean of the Faculty of Pharmacy.

 

Congratulations
The family of the Faculty of Pharmacy extends its heartfelt congratulations
to Professor Dr.
Gihan Nabil Hassan Fetih


on the occasion of the presidential decree
appointing her as the Dean of the Faculty of Pharmacy.

Wishing her further progress and success in her role.

أسرة كلية الصيدلة تهنئ السيدة الأستاذ الدكتورة/ جيهان نبيل حسن فتيح - بمناسبة صدور القرار الجمهورى وتعيين سيادتها عميداُ لكلية الصيدلة

 

 

 

 

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خبر عام

The Faculty of Pharmacy extends its congratulations to Prof. Dr. Gamal Ahmed Saleh, Professor Emeritus in the Department of Pharmaceutical Analytical Chemistry and former Dean of the Faculty, on the occasion of his re-election to the membership of the Pha

Congratulations
Professor Dr. Gihan Nabil Hassan Fetih - Dean of the Faculty
And the esteemed deputies, department heads, faculty members, and their assistants

And the Faculty secretary and the members of the administrative staff at the Faculty
Extend their sincere congratulations to
Professor Dr. Gamal Ahmed Saleh
Professor in the Department of Pharmaceutical Analytical Chemistry and former Dean of the Faculty
On the occasion of his re-election to the membership of the Pharmaceutical Studies Sector Committee
Of the Supreme Council of Universities for the term 2025 - 2028
With best wishes for success and further progress and prosperity

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خبر عام

Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors

Research Abstract

A novel series of 1,2,3-triazole/1,2,4-oxadiazole hybrids (7a–o) was developed as dual inhibitors of EGFR/
VEGFR-2. Compounds 7a–o were evaluated as antiproliferative agents with Erlotinib as the reference drug.
Results demonstrated that most of the tested compounds showed significant antiproliferative action with
GI50 values ranging from 28 to 104 nM, compared to Erlotinib (GI50 ¼ 33 nM), and compounds 7i–m were
the most potent. Compounds 7h, 7i, 7j, 7k, and 7l were evaluated as dual EGFR/VEGFR-2 inhibitors. These
in vitro experiments demonstrated that compounds 7j, 7k, and 7l are potent antiproliferative agents that
may operate as dual EGFR/VEGFR-2 inhibitors. Compounds 7j, 7k, and 7l were evaluated for their apoptotic
potential activity, where findings indicated that compounds 7j, 7k, and 7l promote apoptosis by activating
caspase-3, 8, and Bax and down-regulating the anti-apoptotic Bcl-2. Molecular docking simulations show
the binding mode of the most active antiproliferative compounds within EGFR and VEGFR-2 active sites.

Research Authors
Mohamed A. Mahmoud, Anber F. Mohammed, Ola I. A. Salem, Tahani Mazyad Almutairi, Stefan Bräse, Bahaa G. M. Youssif
Research Journal
Journal of Enzyme Inhibition and Medicinal Chemistry
Research Publisher
Taylor and Francis
Research Rank
Q1, Medicinal Chemistry
Research Vol
39(1)
Research Year
2024

Benzimidazole-based derivatives as apoptotic antiproliferative agents: Design, synthesis, docking, and mechanistic studies

Research Abstract

A new class of benzimidazole-based derivatives (4a–j, 5, and 6) with potential dual
inhibition of EGFR and BRAFV600E has been developed. The newly synthesized compounds were
submitted for testing for antiproliferative activity against the NCI-60 cell line. All newly synthesized
compounds 4a–j, 5, and 6 were selected for testing against a panel of sixty cancer cell lines at a single
concentration of 10 μM. Some compounds tested demonstrated remarkable antiproliferative activity
against the cell lines tested. Compounds 4c, 4e, and 4g were chosen for five-dose testing against
60 human tumor cell lines. Compound 4c demonstrated strong selectivity against the leukemia
subpanel, with a selectivity ratio of 5.96 at the GI50 level. The most effective in vitro anti-cancer
assay derivatives (4c, 4d, 4e, 4g, and 4h) were tested for EGFR and BRAFV600E inhibition as potential
targets for antiproliferative action. The results revealed that compounds 4c and 4e have significant
antiproliferative activity as dual EGFR/BRAFV600E inhibitors. Compounds 4c and 4e induced
apoptosis by increasing caspase-3, caspase-8, and Bax levels while decreasing the anti-apoptotic Bcl2
protein. Moreover, molecular docking studies confirmed the potential of compounds 4c and 4e to act
as dual EGFR/BRAFV600E inhibitors

Research Authors
Bahaa G. M. Youssif, Martha M. Morcoss, S. Bräse, Mohamed Abdel-Aziz, Hamdy M. Abdel-Rahman, Dalal A. Abou El-Ella, El Shimaa M. N. Abdelhafez
Research Journal
Molecules
Research Publisher
MDPI
Research Rank
Medicinal Chemistry Q2
Research Vol
29(2)
Research Year
2024

Important Announcement for Bachelor of Pharmacy (Pharm D) and Bachelor of Pharmacy (Clinical Pharmacy) Students

 

It has been decided to open the appeals regarding the courses of the first semester of the 2024/2025 academic year, starting from Monday, January 27, 2025, to Thursday, January 30, 2025.

Students who wish to submit appeals should go to the Education and Students Affairs Department and pay an amount of 100 Egyptian Pounds per course, to be paid at the treasury.

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إعلانات الطلاب

The Faculty of Pharmacy at Assiut University Announces the 17th Edition of the "Step on the Way " Conference

The Faculty of Pharmacy at Assiut University will launch the 17th edition of the "Step on the Way " (SOTW-17) conference from February 3 to 6, 2025, at the Administrative Building at Assiut University. The conference will involve the participation of various pharmacy faculties from public, private, and national universities across Upper Egypt.

As part of its ongoing efforts to develop the skills of students at the Faculty of Pharmacy at Assiut University and prepare them for the job market, the Faculty's Scientific Association (EPSF-Assiut) is organizing this important scientific event. The conference aims to enhance student competence and prepare them for a successful professional future.

The conference will be held under the patronage of Professor Dr. Ahmed El-Menshawi, President of Assiut University, Professor Dr. Ahmed Abdel-Mawla, Vice President for Education and Student Affairs, and under the supervision of Professor Dr. Gehan Nabil, Dean of the Faculty of Pharmacy, and Professor Dr. Hassan Rifaat, Vice Dean for Education and Student Affairs. The event will also receive support and participation from faculty members and leading academic staff.

The conference will feature a distinguished group of professors and specialists in the field of pharmacy, as well as prominent figures from Assiut Governorate and representatives from major pharmaceutical companies. This will make the conference an ideal platform for students to engage with experts across various fields.

Assiut University. Organizes the conference "Step on the road" in its seventeenth edition .. Next February | Assiut University

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