Department Researches & Publications

Department of Medicinal Chemistry

Researches Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products. The research focuses on the following strategic Research Themes: Design and synthesis of new chemical entities. Computer aided drug design studies. Structure-Activity relationship studies. Combinatorial chemistry. Prod rugs developments. Analytical methods for bioavailability and metabolic studies. Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

# Title Research Year
21 Design, synthesis, and molecular docking of novel 1,3, 4-triaryl pyrazole derivatives bearing methylsulfonyl moiety with anticancer activity through dual targeting CDK2 and COX-2 enzymes 2024
22 Insight into the liposomal encapsulation of mono and bis-naphthalimides 2024
23 Piperazine-2-carboxylic acid derivatives as MTDLs anti-Alzheimer agents: Anticholinesterase activity, mechanistic aspect, and molecular modeling studies 2024
24 Quinazoline‐chalcone hybrids as HDAC/EGFR dual inhibitors: Design, synthesis, mechanistic, and in‐silico studies of potential anticancer activity against multiple myeloma 2024
25 Spectral, XRD, morphological, DFT, and molecular modeling investigations of newly prepared isatin Schiff base complexes 2024
26 Tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (THTT), A Versatile Carrier System for Targeting Cell Cycle Checkpoint Pathways with Potential Anticancer Activities 2024
27 Thiadiazine-2-thione Derivatives as New Carrier Systems for Isothiocyanates and Dithiocarbamic acid with Potential Anticancer Activities 2023
28 Thiadiazine-2-thione derivatives as new cell- cycle inhibitors 2023
29 Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages 2022
30 In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy Calculations 2022