Osteoprotegerin, Soluble Receptor Activator Nuclear Factor-κB Ligand, Nuclear Factor Kappa B and Intestinal Trefoil Factor 3 Are Promising Biomarkers In Diagnosis And Follow- up Inflammatory Bowel Disease Patients

Osteoprotegerin, Soluble Receptor Activator Nuclear Factor-κB Ligand, Nuclear Factor Kappa B and Intestinal Trefoil Factor 3 Are Promising Biomarkers In Diagnosis And Follow- up Inflammatory Bowel Disease Patients

Research Abstract

The hypothesis of this study based on OPG is the decoy receptor of sRANKL which bind with its receptor RANK and activate NF-κB. This pathway may involve in the pathogenesis of IBD and any interference with pathway may affect the progress of the disease. The role of RANK/RANKL inhibition as an immunomodulatory.  While TFF3 is a good marker indicating healing of mucosa   and a state of remission.

Research Authors
Ragaa HM Salama , Mohammed A Medhat, Shimaa A Elghazally , Nesma G Farag, Aya A El Sanory ,Mohamed O Herdan, Tasneem A El Sanory , Amira A kamel .
Research Date
Research Department
Department of Biochemistry
Research Journal
The Egyptian Journal of Hospital Medicine
Research Member
Nesma Gamal Abd Elnaem Farag