This study was done to determine the impact of monieziosis infection combined with hypomicroelementosis on some hematological, biochemical and hormonal parameters of Soviet Merino sheep in the Astrakhan region. 20 sheep, aging 3 years old and average 43±1. 6 kg body weight is used. Sheep were divided into two groups. First group contained 10 sheep and these sheep were naturally infected with monieziosis and clinically were suffered from hypomicroelementosis, emaciation, reduced growth rate, anemia, diarrhea and pale mucosa. Second group contained 10 sheep were apparently healthy and free from internal parasites and they were used as a control group. The first group was given Praziver (praziquantel and ivermectin) for treatment monieziosis, while they intramuscularly injected with Sedimin (selenium, iodine and iron) and were introduced daily into the feed with CoCl 2. Faecal and blood samples from both groups were collected, before and 30 days after treatment, and analyzed for some hematological, biochemical and hormonal parameters. Our results revealed that there was a significant decrease in Hb and RBCs values, while total WBCs and eosinophils were significantly increased in the diseased group than in healthy one. Biochemical analysis showed a significant decrease in serum antioxidant enzymes (CAT, SOD and GSH-Px) and a significant increase in serum DC and MDA in the diseased group as compared with the control group. Hormonal analysis showed a significant increase in ACTH, TSH, Cortisol and a significant decrease in serum T4 and T3. After treatment with Praziver, Sedemin and CoCl2, there was a significant effectiveness to maintain blood parameters within normal levels in the experimental group and increase reproductive outcome from these sheep.