The global feeding on Western diet, which is enriched in fat and fructose, has been proposed to be a cause of metabolic disorder, including hepatic steatosis which is associated with oxidative stress. In the present study, we investigated the influence of co-treatment with phytochemical compounds, quercetin (Q), o-coumaric (CA) and berberine (BB) on the hepatic lipid profile and oxidative stress markers of rats fed a HFS diet. Rats fed HFS diet showed hypertriglycemia, hypercholesterolemia, and alteration of oxidative markers in hepatic tissues and serum and histological changes in liver tissues. Supplementing a HFS diet with CA and BB ameliorates hypertriglycemia, hypercholesterolemia and oxidative stress biomarkers. However, Q improved the biochemical changes in lipid profile and oxidative stress, but failed to improve the histological changes in liver tissue. In conclusion, the present results evidences indicate that CA and BB could be considered as promising complementary treatments against hepatic steatosis development associated with HFS.

Lithium (Li) therapy has widely used in the treatment of bipolar disorder. Consequently, consciousness of the side effects and pathogenesis of this metal is needed for such treatments. Recently, information on the interaction of Li with oxidative markers and organs toxicity attend the researchers over the world. In the present study we have tried to evaluate the influence of oral administration of LiCl for 4 weeks on the oxidative stress marker and histological structure of brain in male rats. Fifty adult male albino rats weighing 135±15 gm was categorized into 5 groups (10 rats each). Group I worked as negative control, group II administrated with LiCl (0.20 mg/kg bw) in drinking water, group III, IV and V were administrated with Zn (10 mg/kg bw), VE (100 mg/kg bw) and their combination twice a week besides the daily administration of LiCl for 4 weeks, respectively. Rats after anesthesia with ether killed for collocation of brain for histopathological and biochemical analysis. Data obtained showed a significant increase in LPO, NO, GSH and Li content and the activities of SOD, CAT and AChE with demylination of the nerve fibers and degeneration of neurons in brain of LiCl treated rats. Co-treatment of ratswith Zn or VE results in a significant decrease in LPO, NO, GSH content in the activities of SOD, CAT and AChE with less or normal structure of the brain. However, co-treatment with combination of Zn and VE caused a significant increase in SOD, CAT and AChE activities with normal histological structure.In conclusion, the data from the present study show that Zn and VE and their interaction are effective in protection against Liinduced brain toxicity in rat with priority for the combination.

Lithium (Li) therapy has widely used in the treatment of bipolar disorder. Consequently, consciousness of the side effects and pathogenesis of this metal is needed for such treatments. Recently, information on the interaction of Li with oxidative markers and organs toxicity attend the researchers over the world. In the present study we have tried to evaluate the influence of oral administration of LiCl for 4 weeks on the oxidative stress marker and histological structure of brain in male rats. Fifty adult male albino rats weighing 135±15 gm was categorized into 5 groups (10 rats each). Group I worked as negative control, group II administrated with LiCl (0.20 mg/kg bw) in drinking water, group III, IV and V were administrated with Zn (10 mg/kg bw), VE (100 mg/kg bw) and their combination twice a week besides the daily administration of LiCl for 4 weeks, respectively. Rats after anesthesia with ether killed for collocation of brain for histopathological and biochemical analysis. Data obtained showed a significant increase in LPO, NO, GSH and Li content and the activities of SOD, CAT and AChE with demylination of the nerve fibers and degeneration of neurons in brain of LiCl treated rats. Co-treatment of ratswith Zn or VE results in a significant decrease in LPO, NO, GSH content in the activities of SOD, CAT and AChE with less or normal structure of the brain. However, co-treatment with combination of Zn and VE caused a significant increase in SOD, CAT and AChE activities with normal histological structure.In conclusion, the data from the present study show that Zn and VE and their interaction are effective in protection against Liinduced brain toxicity in rat with priority for the combination.

Lithium (Li) therapy has widely used in the treatment of bipolar disorder. Consequently, consciousness of the side effects and pathogenesis of this metal is needed for such treatments. Recently, information on the interaction of Li with oxidative markers and organs toxicity attend the researchers over the world. In the present study we have tried to evaluate the influence of oral administration of LiCl for 4 weeks on the oxidative stress marker and histological structure of brain in male rats. Fifty adult male albino rats weighing 135±15 gm was categorized into 5 groups (10 rats each). Group I worked as negative control, group II administrated with LiCl (0.20 mg/kg bw) in drinking water, group III, IV and V were administrated with Zn (10 mg/kg bw), VE (100 mg/kg bw) and their combination twice a week besides the daily administration of LiCl for 4 weeks, respectively. Rats after anesthesia with ether killed for collocation of brain for histopathological and biochemical analysis. Data obtained showed a significant increase in LPO, NO, GSH and Li content and the activities of SOD, CAT and AChE with demylination of the nerve fibers and degeneration of neurons in brain of LiCl treated rats. Co-treatment of ratswith Zn or VE results in a significant decrease in LPO, NO, GSH content in the activities of SOD, CAT and AChE with less or normal structure of the brain. However, co-treatment with combination of Zn and VE caused a significant increase in SOD, CAT and AChE activities with normal histological structure.In conclusion, the data from the present study show that Zn and VE and their interaction are effective in protection against Liinduced brain toxicity in rat with priority for the combination.

Animal kingdom possesses numerous poisonous species that produce venoms (actively delivered) or toxins (passively delivered). Poisonous animals are found in most classes of the Animal Kingdom and in most habitats, both terrestrial and marine. Poisonous animals have a significant health problem for populations in the world and are neglected environmental diseases of the rural tropics. Poisonous animals include a variety of animal species; sea snakes, stinging fish, jellyfish, corals, cone shells, blueringed octopuses, sea urchins, snakes (elapids, vipers, and rattlesnakes), scorpion, spiders, bee, wasp and ant. Poisonous animal are rich sources of toxins that often target-with high potency and variable specificity. Animal toxins have made a significant contribution to enhancing knowledge in human physiology and pharmacology. Information on the nature and mechanism of action of these toxins has enabled a more scientific approach to the treatment of their intoxications. This paper reviews the knowledge about the various aspects related to the name, habitat, biological and medical importance of poisonous animals of different major animal phyla. In addition, this review will discuss the mechanism of venoms or toxins toxicity and therapeutic uses of particular fractions of venoms or toxins from different sources

Obesity is associated with abnormal adipokines production and activation of inflammatory signal pathways in adipose tissue. Also, there is rising facts about the relation between the adiponectin function and pathogenesis of type 2 diabetes. The aim of this study is to investigate the relationship between the levels of leptin, adiponectin, tumor necrosis factor alpha (TNF-α) and lymphocytes count in diabetic and obese diabetic participants and its significance in the etiology of diabetes and obesity in Sohag

Recently consideration attentions drawn to investigation of channeling gas discharges,, which find extensive practical applications, particularly, in laser techniques. An almost chronological survey of the literature traces the development of the subject form its beginning, and a number of the applications are given. Based on the analysis of the obtained results of experimental and theoretical investigations, modern concepts of the channeling mechanism of discharge and analysis of the behavior of excitation and ...