Animal kingdom possesses numerous poisonous species that produce venoms (actively delivered) or toxins (passively delivered). Poisonous animals are found in most classes of the Animal Kingdom and in most habitats, both terrestrial and marine. Poisonous animals have a significant health problem for populations in the world and are neglected environmental diseases of the rural tropics. Poisonous animals include a variety of animal species; sea snakes, stinging fish, jellyfish, corals, cone shells, blueringed octopuses, sea urchins, snakes (elapids, vipers, and rattlesnakes), scorpion, spiders, bee, wasp and ant. Poisonous animal are rich sources of toxins that often target-with high potency and variable specificity. Animal toxins have made a significant contribution to enhancing knowledge in human physiology and pharmacology. Information on the nature and mechanism of action of these toxins has enabled a more scientific approach to the treatment of their intoxications. This paper reviews the knowledge about the various aspects related to the name, habitat, biological and medical importance of poisonous animals of different major animal phyla. In addition, this review will discuss the mechanism of venoms or toxins toxicity and therapeutic uses of particular fractions of venoms or toxins from different sources