Skip to main content

Control Functions in G-Metric Spaces: Novel Methods for θ-Fixed Points and θ-Fixed Circles with an Application

Research Abstract

The purpose of this paper is to present some new contraction mappings via control functions. In addition, some fixed point results for Θ,α,θ,Ψ contraction, rational Θ,α,θ,Ψ contraction and almost Θ,α,θ,Ψ contraction mappings are obtained. Moreover, under contraction mappings of types (I), (II), and (III) of Θ,θ,Ψυ0, several fixed circle solutions are provided in the setting of a G-Metric space. Our results extend, unify, and generalize many previously published papers in this direction. In addition, some examples to show the reliability of our results are presented. Finally, a supporting application that discusses the possibility of a solution to a nonlinear integral equation is incorporated.

Research Authors
Hasanen A. Hammad, Maryam G. Alshehri and Ayman Shehata
Research Date
Research Department
Research File
Research Journal
symmetry
Research Pages
164
Research Publisher
https://www.mdpi.com/2073-8994/15/1/164
Research Rank
Q2
Research Vol
15
Research Website
https://doi.org/10.3390/sym15010164
Research Year
2023

On some properties of the bibasic Humbert hypergeometric functions E1 and E2

Research Abstract

The main object of this paper is to deduce the bibasic Humbert functions Ξ1 and Ξ2
Some interesting results and elementary summations technique that was successfully employed,
q?recursion, q?derivatives relations, the q?differential recursion relations, the q?integral representations
for Ξ1 and Ξ2 are given. The summation formula derives a list of p?analogues
of transformation formulas for bibasic Humbert functions that have been studied, also some
hypergeometric functions properties of some new interesting special cases have been given.

Research Authors
CAI Qing-bo, Ghazi S. Khammash, Shimaa I. Moustafa and Ayman Shehata
Research Date
Research Department
Research File
Research Journal
Appl. Math. J. Chinese Univ.
Research Pages
614-630
Research Publisher
https://link.springer.com/article/10.1007/s11766-023-4848-8
Research Rank
Q2
Research Vol
38(4)
Research Website
https://doi.org/10.1007/s11766-023-4848-8
Research Year
2023

Magma fractionation and emplacement mechanism in a subvolcanic plumbing system in a continental region: constraints from the late Neoproterozoic Wadi Dib ring complex in the Eastern Desert, Egypt

Research Abstract

We examined an alkaline ring complex in the Eastern Desert of Egypt, Wadi Dib ring complex (WDRC), to understand formation mechanisms of the intimately related ring structure and chemical diversity. The WDRC consists of multiple circular rings of the oldest volcanic units, the middle-stage plutonic unit, and the youngest dike unit, and these units show overlapping whole-rock major element compositions. The compositional variation of the volcanic and plutonic units can be accounted for by a stepwise fractional crystallization starting with a trachytic magma without significant magma replenishment or crustal contamination. From the margin to the center and oldest to youngest, the plutonic unit consists of an outer ring (syenite), inner rings 1 (quartz-bearing syenite) and 2 (quartz syenite), and a granitic core (syenogranite). The whole-rock chemical composition of the plutonic unit is progressively more fractionated inwards from the outer ring to the granitic core through the inner rings. Syenites from the innermost outer ring show high degree of deformation, which gradually decreases outwards in the outer ring and abruptly decreases inwards in the outermost inner ring 1. The deformed syenites show microstructures suggesting reactive melt transportation. The country rocks neighboring the ring complex and equivalent blocks present in the periphery of the outer ring, the overlying volcanic unit and equivalent blocks present in the inner rings all show microstructures indicative of pyrometamorphism. Spatial variations in the microstructures in the plutonic unit indicate an increase in cooling rate from the outer ring to the granitic core and thus with time …

Research Authors
Eman Saad, Kazuhito Ozawa, Takeshi Kuritani, Ali A Khudeir
Research Date
Research Department
Research Journal
Journal of Mineralogical and Petrological Sciences
Research Pages
220801
Research Publisher
Japan Association of Mineralogical Sciences
Research Vol
Volume 118, Issue 1
Research Website
https://scholar.google.com.eg/scholar?oi=bibs&cluster=7546730743683401702&btnI=1&hl=en
Research Year
2023

New host record, Sclerophrys regularis (Bufonidae), for Rhabdias africanus (Rhabdiasidae, Kuzmin, 2001) based on molecular and morphological evidence

Research Abstract
With diversity of hosts range, most identified nematode species still lack the crucial connection between
morphological and molecular make-up, which is important for precisely classifying the specimens. The
present study provides the complete description of Rhabdias africanus in the new host record,
Sclerophrys regularis. Fifty toad specimens were collected, and a high prevalence of R. africanus infection
(74%) was observed. Morphology and ultrastructure were observed using light and scanning electron
microscopes. Morphological characteristics, including peculiarities of the head, the shape and position
of the lips, and the number of labial papillae, were described. The length of the body, the esophageal
length, the distance from an anterior end to the nerve ring, and the tail length were reduced in the stud
ied samples relative to previously described specimens. Furthermore, some variable matrices that have
not previously been described, e.g., ovarian part widening, the nerve ring and its location, and eggs with
different stages of larvae, were included in the present study. Genus and species identification was con-
firmed by comparing partial 12S (619 bp) and ITS (878 bp) gene sequences to those of Rhabdias species
deposited in GenBank. The studied species showed a 99.34% resemblance to R. africanus from South
Africa. We assume our findings will aid in the molecular identification of adult and larval stages of this
genus in amphibians. We strongly recommend further studies on the environmental factors that promote
Rhabdias infection and transmission.
Research Authors
Sara S. Abdel-Hakeem, Yousef A. Fadladdin, Atef M. El-Sagheer, Asmaa Adel
Research Date
Research Department
Research Pages
103366
Research Publisher
Saudi journal of biological science
Research Vol
29
Research Year
2022

Nanocurcumin: A Promising Therapeutic Candidate for Experimental Trichinellosis

Research Abstract
In our pursuit of an alternative drug against Trichinella spiralis, we assessed the effectiveness of nanocurcumin in alleviating pathogenesis,
parasitological factors, MMP-9 levels, and its expression in the enteral and parenteral phases of infection. The nanocurcumin particles, with a
spherical shape and a size of 100 ± 20 nm, were used in the study. Eighty mice were divided into four groups: the control group, the
untreated infected group, the nanocurcumin-treated group, and the albendazole-treated group. The nanocurcumin-treated group exhibited a
statistically significant increase in the percentage of lymphocytes, along with a reduction in neutrophils, monocytes, and eosinophils
compared to the untreated, infected group. Both the nanocurcumin (87.2 and 97.3%) and the albendazole-treated groups (99.8 and 98.2%)
showed a significant reduction in the mean number of intestinal worms and encysted larvae, respectively. The treated groups exhibited
normal intestinal villi, suppression of the inflammatory process, and fewer instances of degenerated larvae in the diaphragm and muscle
compared to the untreated, infected group. Immunohistochemistry and ELISA analyses revealed a significant downregulation of MMP-9
levels in the intestines and muscles of the treated groups. Our data demonstrate that nanocurcumin contains highly versatile molecules
capable of modulating biological activity against inflammation and its pathway markers.
Research Authors
Sara Salah Abdel-Hakeem, Mahmoud Abdel-Zaher Abdel-Samiee, Mohamed Salah Eldin Youssef, Shimaa Hamdi Abd-Elsadek, Salwa Mahmoud Abd-Elrahman, and Sally Salah Abdel-Hakeem
Research Date
Research Department
Research Pages
1-14
Research Publisher
Microscopy and microanalysis
Research Vol
00
Research Year
2024

Assessment of cattle tick infestation: Molecular insights into Rhipicephalus annulatus and the efficacy of garlic oil and nanoemulsion as acaricidal agents

Research Abstract
Ticks, particularly Rhipicephalus annulatus, pose significant threats to livestock, causing economic losses and
transmitting various infectious diseases. This study aimed to evaluate the potential acaricidal properties of garlic
oil and its nanoemulsion against ticks infesting cattle, Rhipicephalus annulatus through the evaluation of mortality
rate and morphological changes of the treated ticks. The study also included prevalence, risk factors, and mo
lecular confirmation of tick species. Genetic characterization confirmed the identity of R. annulatus. Our results
revealed a high prevalence of R. annulatus (46.9%) with a higher risk in male cattle (50%) than females (44.9%)
and a nonsignificant high infection (49.1%) in animals 1 year old. The acaricidal efficiency of garlic oil and its
nanoemulsion was concentration and time-dependent. The high concentration of garlic oil (20 mg/L) induced
complete mortality within 48 hours. The nanoemulsion formulation enhanced efficacy, particularly at 5 mg/L,
which exhibited rapid and substantial acaricidal activity. Scanning electron microscopy revealed morphological
alterations induced by garlic oil and its nanoemulsion, including changes to the anterior capitulum, dorsal, and
ventral cuticles. The study contributes to the exploration of effective, safe, and eco-friendly alternatives for tick
control. Further research is warranted to validate their efficacy under diverse conditions and assess practical
strategies.
Research Authors
Salwa Mahmoud Abd-Elrahman, Ahmed Kamal Dyab, Fatma Atea Kamel, Abeer A. Khedr, Mervat M. Khalifa, Shaymaa M. Mohamed , Sara Salah Abdel-Hakeem
Research Date
Research Department
Research Pages
110211
Research Publisher
Veterinary Parasitology
Research Vol
329
Research Year
2024

Modulation of the intestinal mucosal and cellmediated response against natural helminth infection in the African catfish Clarias gariepinus

Research Abstract
Abstract
Fish gut is a versatile organ serving as the primary pathway for invasion by pathogens, particularly parasites,
playing a crucial role in modulating the intestinal adaptive immune response. This study aimed to investigate the
cellular-mediated reaction, mucosal acidity, and the expression of proliferating cell nuclear antigen (PCNA), vascular
endothelial growth factor (VEGF), and CD68 in the intestines of catfish, Clarias gariepinus, naturally infected with
helminths. Forty catfish were collected from the Nile River and examined for intestinal parasites. The intestinal
tissues of the control and infected fish were fixed for histochemical and immunohistochemical studies. Two
groups of helminths were found: cestodes Tetracampos ciliotheca and Polyonchobothrium clarias, and nematodes
Paracamallanus cyathopharynx, with a prevalence rate of 63.63%, 18.0%, and 18.0%, respectively. Our results
showed that the infected fish had a statistically significant rise in the activity of immune cells, including mast cells,
eosinophil granular cells, and dendritic cells. This correlated with upregulation in the expressions of PCNA, VEGF,
and CD68. Histochemical analyses demonstrated a marked increase in acidic mucus production, Sudan black B,
and bromophenol mercury blue. This study enriches our understanding of the evolution of vertebrate immunity in
combating intestinal parasitic infections and the host’s adaptive responses.
Research Authors
Sara Salah Abdel-Hakeem, Yousef Abdal Jalil Fadladdin, Mohsen A. Khormi, and Hanan H. Abd-El-Hafeez
Research Date
Research Department
Research Pages
335
Research Publisher
BMC veterinary research
Research Vol
20
Research Year
2024

Pumpkin seed oil: unveiling its potential in controlling infammation and pathogenicity during experimental trichinellosis

Research Abstract
Abstract
Background This study aimed to investigate the antiparasitic and anti-infammatory potential of pumpkin seed oil
in mice infected with Trichinella spiralis by demonstrating its impact on MMP-9 expression and pathogenesis dur‑
ing the intestinal and muscular phases.
Results In this study, 100 mice were divided into fve groups: an infected group, a pumpkin seed oil-treated
group (1.5 mg/kg BW, administered three times per week), an albendazole-treated group, a native control group,
and a pumpkin oil control group. Gas chromatography–mass spectrometry analysis of the pumpkin seed oil revealed
a broad spectrum of biologically active compounds. The pumpkin seed oil treatment led to a signifcant reduction
in the parasite burden, with a 75% decrease in adult worms and a 66% decrease in encysted larvae. Additionally,
the infected animals treated with pumpkin oil exhibited a marked reduction in intestinal infammation, character‑
ized by a progressive increase in goblet cells. The number of encysted larvae in the diaphragm and muscle tissues
was also signifcantly decreased. Furthermore, pumpkin seed oil treatment signifcantly reduced MMP-9 levels
in both intestinal and muscular tissues, highlighting its potential to attenuate infammation.
Conclusion These fndings underscore the efectiveness of pumpkin seed oil as anti-infammatory and antiparasitic
agent.
Research Authors
Sara Salah Abdel‑Hakeem, Sulaiman Mohammed Alnasser, Alotaibi Meshal, Mahmoud Abdel‑Zaher Abdel‑Samiee, Mohamed Salah Eldin Youssef, Shimaa Hamdi Abd Elsadek and Salwa Mahmoud Abd‑Elrahman
Research Date
Research Department
Research Pages
419
Research Publisher
BMC veterinary research
Research Vol
20
Research Year
2024

Combating the causative agent of amoebic keratitis, Acanthamoeba castellanii, using Padina pavonica alcoholic extract: toxicokinetic and molecular docking approaches

Research Abstract
Natural products play a signifcant role in providing the current demand as antiparasitic agents,
which ofer an attractive approach for the discovery of novel drugs. The present study aimed to
evaluate in vitro the potential impact of seaweed Padina pavonica (P. pavonica) extract in combating
Acanthamoeba castellanii (A. castellanii). The phytochemical constituents of the extract were
characterized by Gas chromatography–mass spectrometry. Six concentrations of the algal extract
were used to evaluate its antiprotozoal activity at various incubation periods. Our results showed that
the extract has signifcant inhibition against trophozoites and cysts viability, with complete inhibition
at the high concentrations. The IC50 of P. pavonica extract was 4.56 and 4.89 µg/mL for trophozoites
and cysts, respectively, at 24 h. Morphological alterations of A. castellanii trophozoites/cysts treated
with the extract were assessed using inverted and scanning electron microscopes and showed severe
damage features upon treatment with the extract at diferent concentrations. Molecular Docking
of extracted compounds against Acanthamoeba cytochrome P450 monooxygenase (AcCYP51) was
performed using Autodock vina1.5.6. A pharmacokinetic study using SwissADME was also conducted
to investigate the potentiality of the identifed bioactive compounds from Padina extract to be orally
active drug candidates. In conclusion, this study highlights the in vitro amoebicidal activity of P.
pavonica extract against A. castellanii adults and cysts and suggests potential AcCYP51 inhibition.
Research Authors
Sara S.Abdel‑Hakeem, FatenA. M. Hassan, Awatief F. Hifney, Shimaa H. Salem
Research Date
Research Department
Research Pages
13610
Research Publisher
Scientific reports
Research Vol
14
Research Year
2024
Subscribe to