Cisplatin (CP) is considered as a major antineoplastic drug against a broad spectrum of malignancies. CP acts on cancer cells by releasing free radicals which at the same time damage liver and kidney cells. In this study, we aimed to investigate the hepatotoxicity of CP which it may be mediated by oxidative stress and to establish whether some antioxidants, Vit C, DPPD and L-cystiene, may provide protection against CP hepatotoxicity. 40 rats were divided into 5 groups. G1 work as control, G2 injected with CP alone, G3 was injected with CP & Vit C, G4 was injected with CP& DPPD, G5 was injected with CP & L-cystiene. CP-induced oxidative stress was indicated by ↑ LPO and O2- in hepatic tissue and plasma. Also, CP induced decline of SOD, CAT, GST and GGT and a ↓ level of GSH, Vit C and Vit E in hepatic tissue and plasma. Treatment with Vit C, DPPD and L-cysteine in combination with CP restored LPO and O2-, the activities of SOD, GST, CAT and GGT and the content of GSH, Vit C and Vit E to control levels

Cisplatin (CP) is considered as a major antineoplastic drug against a broad spectrum of malignancies. CP acts on cancer cells by releasing free radicals which at the same time damage liver and kidney cells. In this study, we aimed to investigate the hepatotoxicity of CP which it may be mediated by oxidative stress and to establish whether some antioxidants, Vit C, DPPD and L-cystiene, may provide protection against CP hepatotoxicity. 40 rats were divided into 5 groups. G1 work as control, G2 injected with CP alone, G3 was injected with CP & Vit C, G4 was injected with CP& DPPD, G5 was injected with CP & L-cystiene. CP-induced oxidative stress was indicated by ↑ LPO and O2- in hepatic tissue and plasma. Also, CP induced decline of SOD, CAT, GST and GGT and a ↓ level of GSH, Vit C and Vit E in hepatic tissue and plasma. Treatment with Vit C, DPPD and L-cysteine in combination with CP restored LPO and O2-, the activities of SOD, GST, CAT and GGT and the content of GSH, Vit C and Vit E to control levels

Cisplatin (CP) is considered as a major antineoplastic drug against a broad spectrum of malignancies. CP acts on cancer cells by releasing free radicals which at the same time damage liver and kidney cells. In this study, we aimed to investigate the hepatotoxicity of CP which it may be mediated by oxidative stress and to establish whether some antioxidants, Vit C, DPPD and L-cystiene, may provide protection against CP hepatotoxicity. 40 rats were divided into 5 groups. G1 work as control, G2 injected with CP alone, G3 was injected with CP & Vit C, G4 was injected with CP& DPPD, G5 was injected with CP & L-cystiene. CP-induced oxidative stress was indicated by ↑ LPO and O2- in hepatic tissue and plasma. Also, CP induced decline of SOD, CAT, GST and GGT and a ↓ level of GSH, Vit C and Vit E in hepatic tissue and plasma. Treatment with Vit C, DPPD and L-cysteine in combination with CP restored LPO and O2-, the activities of SOD, GST, CAT and GGT and the content of GSH, Vit C and Vit E to control levels

Cisplatin (CP) is considered as a major antineoplastic drug against a broad spectrum of malignancies. CP acts on cancer cells by releasing free radicals which at the same time damage liver and kidney cells. In this study, we aimed to investigate the hepatotoxicity of CP which it may be mediated by oxidative stress and to establish whether some antioxidants, Vit C, DPPD and L-cystiene, may provide protection against CP hepatotoxicity. 40 rats were divided into 5 groups. G1 work as control, G2 injected with CP alone, G3 was injected with CP & Vit C, G4 was injected with CP& DPPD, G5 was injected with CP & L-cystiene. CP-induced oxidative stress was indicated by ↑ LPO and O2- in hepatic tissue and plasma. Also, CP induced decline of SOD, CAT, GST and GGT and a ↓ level of GSH, Vit C and Vit E in hepatic tissue and plasma. Treatment with Vit C, DPPD and L-cysteine in combination with CP restored LPO and O2-, the activities of SOD, GST, CAT and GGT and the content of GSH, Vit C and Vit E to control levels

Fundamental (lattice, rotational, and intermolecular) vibrations of the H2AsO−4 anion in (C6H9N2)H2AsO4 crystal are calculated using the correlation theorem based on the group theory. The correlation between anionic site of symmetry Cs and the factor group D2h of the crystal yields 12 modes for both lattice and rotational vibrations. The infrared and Raman spectra of these modes do not coincide. Addition of two hydrogen atoms to AsO−4 ion yields two As—OH bonds in the H2AsO−4 anion. As a result, the molecular symmetry is reduced from Td to C2v. The free H2AsO−4 anion having C2v symmetry gives in total 15 fundamental normal vibrations. Under the crystal field splitting effects, the number of intermolecular vibrations for the anion in infrared and Raman spectra is calculated to be 56 active vibrations. The calculated fundamental vibrations manifest themselves as the main features in an experimental infrared spectrum.

Spinel Cu0.5Zn0.5Fe2O4 ferrite doped with different rare earth ions is investigated. FT-IR was used to investigate the effect of different rare earth substitution on the magnetic properties of this system. It was found that when Fe3+ is replaced with La and Nd ions, almost no changes were observed in the band position of IR spectra. As Gd and Dy substituted, small shifts for the band spectra were detected. On the other hand when Sm is replacing Fe3+ a noticed increase in the frequency band position was observed. The observed increase in the band ν1 position for Sm substitution can be explained as the replace of Fe3+ ions with Sm3+ ions in the tetrahedral site (A-site) of the spinel.

Thin filmsofZn40Se60 were preparedbythevacuumthermalevaporationtechnique.Theinfluenceof annealedtemperatureonthestructuralandopticalpropertieswasinvestigatedusingtheX-ray diffraction(XRD),scanningelectronmicroscopy(SEM)andopticaltransmission.TheXRDstudiesshow that theas-depositedfilmisamorphousinnature,butthecrystallinityimprovedwithincreasingthe annealingtemperature.Furthermoretheparticlesizeandcrystallinityincreasedwhereasthedisloca- tion andstrainsdecreasedwithincreasingtheannealingtemperature.SEMstudiesshowedthatthe annealingtemperatureinducedchangesinthemorphologyoftheas-depositedsample.Variousoptical constanthavebeencalculatedforas-depositedandannealedfilms.Themechanismoftheoptical absorptionfollowstheruleofdirecttransition.Itwasfoundthat,theopticalenergygap(Eg) decreased with increasingtheannealingtemperature.TheseresultscanbeinterpretedbytheDavisandMotte model. Ontheotherhandthemaximumvalueoftherefractiveindex(n) isshiftedtowardthelong wavelengthbyincreasingtheannealingtemperature.

Thin filmsofZn40Se60 were preparedbythevacuumthermalevaporationtechnique.Theinfluenceof annealedtemperatureonthestructuralandopticalpropertieswasinvestigatedusingtheX-ray diffraction(XRD),scanningelectronmicroscopy(SEM)andopticaltransmission.TheXRDstudiesshow that theas-depositedfilmisamorphousinnature,butthecrystallinityimprovedwithincreasingthe annealingtemperature.Furthermoretheparticlesizeandcrystallinityincreasedwhereasthedisloca- tion andstrainsdecreasedwithincreasingtheannealingtemperature.SEMstudiesshowedthatthe annealingtemperatureinducedchangesinthemorphologyoftheas-depositedsample.Variousoptical constanthavebeencalculatedforas-depositedandannealedfilms.Themechanismoftheoptical absorptionfollowstheruleofdirecttransition.Itwasfoundthat,theopticalenergygap(Eg) decreased with increasingtheannealingtemperature.TheseresultscanbeinterpretedbytheDavisandMotte model. Ontheotherhandthemaximumvalueoftherefractiveindex(n) isshiftedtowardthelong wavelengthbyincreasingtheannealingtemperature.

Thin filmsofZn40Se60 were preparedbythevacuumthermalevaporationtechnique.Theinfluenceof annealedtemperatureonthestructuralandopticalpropertieswasinvestigatedusingtheX-ray diffraction(XRD),scanningelectronmicroscopy(SEM)andopticaltransmission.TheXRDstudiesshow that theas-depositedfilmisamorphousinnature,butthecrystallinityimprovedwithincreasingthe annealingtemperature.Furthermoretheparticlesizeandcrystallinityincreasedwhereasthedisloca- tion andstrainsdecreasedwithincreasingtheannealingtemperature.SEMstudiesshowedthatthe annealingtemperatureinducedchangesinthemorphologyoftheas-depositedsample.Variousoptical constanthavebeencalculatedforas-depositedandannealedfilms.Themechanismoftheoptical absorptionfollowstheruleofdirecttransition.Itwasfoundthat,theopticalenergygap(Eg) decreased with increasingtheannealingtemperature.TheseresultscanbeinterpretedbytheDavisandMotte model. Ontheotherhandthemaximumvalueoftherefractiveindex(n) isshiftedtowardthelong wavelengthbyincreasingtheannealingtemperature.