The kinetics of chromic acid oxidation of chondroitin-4-sulfate polysaccharide as sulfated carbohydrates
at a constant ionic strength of 4.0 mol dm−3 has been investigated, spectrophotometrically. The reaction
kinetics showed a first-order dependence in chromic acid and fractional-first-order kinetics with respect
to the chondroitin-4-sulfate concentration. The influence of [H+] on the reaction rates showed that the
oxidation process is acid-catalyzed. Added Mn2+ ions indicated the formation of Cr(IV) as intermediate
species. A kinetic evidence for formation of 1:1 intermediate complex was revealed. The kinetic parameters
have been evaluated and a tentative reaction mechanism in good consistent with the kinetic results
obtained is discussed.

Background. Multiple myeloma (MM), an almost incurable disease, is the second most common blood cancer. Initial
chemotherapeutic treatment could be successful; however, resistance development urges the use of higher toxic doses accompanied by hematopoietic stem cell transplantation. The establishment of more effective treatments that can overcome or circumvent chemoresistance has become a priority.We recently demonstrated that venom extracted fromWalterinnesia aegyptia (WEV) either alone or in combination with silica nanoparticles (WEV+NPs) mediated the growth arrest and apoptosis of prostate cancer cells.In the present study, we evaluated the impact of WEV alone and WEV+NP on proliferation and apoptosis of MM cells. Methods.The impacts of WEV alone and WEV+NP were monitored in MM cells from 70 diagnosed patients. The influences of WEV and WEV+NP were assessed with flow cytometry analysis. Results. WEV alone and WEV+NP decreased the viability of MM cells.Using a CFSE proliferation assay, we found that WEV+NP strongly inhibited MM cell proliferation. Furthermore, analysis of the
cell cycle using the propidium iodide (PI) staining method indicated that WEV+NP strongly altered the cell cycle ofMMcells and enhanced the induction of apoptosis. Conclusions. Our data reveal the biological effects of WEV and WEV+NP on MM cells that enable these compounds to function as effective treatments for MM.

In the present study the protective role of quince leaf extract against the adverse impacts of ultraviolet
radiation-A (UVA) on some tissues of Clarias gariepinus (Burchell, 1822) was considered. Fishes were classified
into four groups: control, UVR-treated group (for 3 days/for 3 h/day), UVR-treated group (for
3 days/for 3 h/day) with adding 10 ml of quince extract, and UVR-treated group (for 3 days/for 3 h/day)
with adding 20 ml of quince leaf extract. Blood smears and sections of the liver, and skin were processed
routinely for H & E paraffin embedding technique. Some UVA-induced malformations were recorded in
the red blood cells including crenated cells (Cr), Acanthocytes (Ac), tear drop-like cells (Tr) and sickle cells
(Sk). Also, UVA-induced disorganization of the normal architecture of hepatic tissues with lipidosis was
evident. Hypertrophy and vacuolated club cells were recorded in skin exposed to UVA. In conclusion,
quince leaf extract has a valuable antioxidant protective role to prevent and/or repair the histopathological
changes induced by UVA.

In the present study the protective role of quince leaf extract against the adverse impacts of ultraviolet
radiation-A (UVA) on some tissues of Clarias gariepinus (Burchell, 1822) was considered. Fishes were classified
into four groups: control, UVR-treated group (for 3 days/for 3 h/day), UVR-treated group (for
3 days/for 3 h/day) with adding 10 ml of quince extract, and UVR-treated group (for 3 days/for 3 h/day)
with adding 20 ml of quince leaf extract. Blood smears and sections of the liver, and skin were processed
routinely for H & E paraffin embedding technique. Some UVA-induced malformations were recorded in
the red blood cells including crenated cells (Cr), Acanthocytes (Ac), tear drop-like cells (Tr) and sickle cells
(Sk). Also, UVA-induced disorganization of the normal architecture of hepatic tissues with lipidosis was
evident. Hypertrophy and vacuolated club cells were recorded in skin exposed to UVA. In conclusion,
quince leaf extract has a valuable antioxidant protective role to prevent and/or repair the histopathological
changes induced by UVA.

In the present study the protective role of quince leaf extract against the adverse impacts of ultraviolet
radiation-A (UVA) on some tissues of Clarias gariepinus (Burchell, 1822) was considered. Fishes were classified
into four groups: control, UVR-treated group (for 3 days/for 3 h/day), UVR-treated group (for
3 days/for 3 h/day) with adding 10 ml of quince extract, and UVR-treated group (for 3 days/for 3 h/day)
with adding 20 ml of quince leaf extract. Blood smears and sections of the liver, and skin were processed
routinely for H & E paraffin embedding technique. Some UVA-induced malformations were recorded in
the red blood cells including crenated cells (Cr), Acanthocytes (Ac), tear drop-like cells (Tr) and sickle cells
(Sk). Also, UVA-induced disorganization of the normal architecture of hepatic tissues with lipidosis was
evident. Hypertrophy and vacuolated club cells were recorded in skin exposed to UVA. In conclusion,
quince leaf extract has a valuable antioxidant protective role to prevent and/or repair the histopathological
changes induced by UVA.

In the present study the protective role of quince leaf extract against the adverse impacts of ultraviolet
radiation-A (UVA) on some tissues of Clarias gariepinus (Burchell, 1822) was considered. Fishes were classified
into four groups: control, UVR-treated group (for 3 days/for 3 h/day), UVR-treated group (for
3 days/for 3 h/day) with adding 10 ml of quince extract, and UVR-treated group (for 3 days/for 3 h/day)
with adding 20 ml of quince leaf extract. Blood smears and sections of the liver, and skin were processed
routinely for H & E paraffin embedding technique. Some UVA-induced malformations were recorded in
the red blood cells including crenated cells (Cr), Acanthocytes (Ac), tear drop-like cells (Tr) and sickle cells
(Sk). Also, UVA-induced disorganization of the normal architecture of hepatic tissues with lipidosis was
evident. Hypertrophy and vacuolated club cells were recorded in skin exposed to UVA. In conclusion,
quince leaf extract has a valuable antioxidant protective role to prevent and/or repair the histopathological
changes induced by UVA.