Do you have any questions? (088) 2080369 - 2345622 Pharmacy_QAAU@pharm.aun.edu.eg
Click
?
Result of the Doctor of Pharmacy (PharmD) first semester of the academic year 2023/2024
Click
?
Click
?
Click
?
All students of the program must quickly pay the fees for the second semester in order to upload the payment list on the electronic testing center platform, noting that in the event of non-payment of fees, the student’s name will be deleted from the list uploaded to the center, and the guardian will also be informed.
It was decided to hold the periodic exam for the “Clinical Pharmacokinetics” course on Thursday, March 28, 2024, in the pharmaceutical laboratories, each in his laboratory.
It was decided to hold the periodic exam for the course “Clinical Pharmacokinetics” on Wednesday, March 27, 2024, in the pharmaceutical laboratories, each in his laboratory.
It was decided to hold the periodic exam for the “Marketing and Pharmacoeconomics” course on Wednesday, March 27, 2024, at 1 p.m., Building (A), fifth floor, in the lecture halls
God willing, the periodic exam will be held for students of the first year of Pharm D National University in the Pharmaceutical Analytical Chemistry - 2 course on Wednesday, March 27, 2024 at twelve noon, Hall (1) and Hall (2), in the following sections: -
1- Acid-base theory
2-Acid-base applications
Topoisomerase (IIB) inhibitors have been involved in the therapies of tumour progression and have become a major focus for the development of anticancer agents. New three-component hybridised ligands, 1,4-disubstituted-1,2,3-triazoles (8–17), were synthesised via a 1,3-dipolar cycloaddition reaction of 9-azidoacridine/3-azidocoumarin with N/O-propargyl small molecules under click reaction conditions. Cancer cell growth inhibition of the synthesised triazoles was tested against human cell-lines in the NCI-60-cell-panel, and the most active compounds tested against topoisomerase (IIB)-enzymes. The acridinyl ligands (8–10) revealed 60–97% cell growth inhibition in six cancer cell-panels. Cell-cycle analysis of MCF7 and DU-145 cells treated with the active acridinyl ligands exhibited cell-cycle arrest at G2/M phase and proapoptotic activity. In addition, compound 8 displayed greater inhibitory activity against topoisomerase (IIB) (IC50 0.52 µM) compared with doxorubicin (IC50 0.83 µM). Molecular dynamics simulation studies showed the acridine–triazole–pyrimidine hybrid pharmacophore was optimal with respect to protein–ligand interaction and fit within the binding site, with optimal orientation to allow for intercalation with the DNA bases (DG13, DC14, and DT9).
God willing, the meeting of the Pharmaceutics Department Board of the Faculty of Pharmacy No. (526) This will be on Monday, April 1, 2024, at 10:30 A.M
in the department board on the third floor under the chairmanship of the Faculty to discuss the topics that we will inform you later.
