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A meeting of the laboratories and scientific equipment committee at the Faculty of Pharmacy on Sunday, April 7, 2024

God willing, the laboratories and scientific equipment committee will hold its meeting on Sunday, April 7, 2024, at 12 :00 (PM).

 in the office of Vice Dean for Community Services and Environmental Development Affairs

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خبر عام

Polypyrrole/carbon dot nanocomposite as an electrochemical biosensor for liquid biopsy analysis of tryptophan in the human serum of normal and breast cancer women

Research Abstract

Liquid biopsy analysis represents a suitable alternative analysis procedure in several cases where no tumor tissue is available or in poor patient conditions. Amino acids can play a crucial role in aiding cancer diagnosis. Monitoring of tryptophan (Trp) catabolism can aid in tracking cancer progression. Therefore, a novel nanocomposite was fabricated using overoxidized polypyrrole film doped with nano-carbon dots (nano-CDs) on the pencil graphite electrode (PGE) surface for sensitive evaluation of Trp in human serum. Using square wave voltammetry (SWV), the overoxidized polypyrrole/carbon dots/pencil graphite electrode (Ov-Ox PPy/CDs/PGE) achieved excellent electrochemical catalytic activity for evaluating Trp. The modified electrode, known as Ov-Ox PPy/CDs/PGE, demonstrated superior electrochemical catalytic activity compared to bare PGE, CDs/PGE, PPy/PGE, and PPy/CDs/PGE for evaluation of Trp. The method’s excellent sensitivity was confirmed by the low limits of detection (LOD = 0.003 μmol L-1) and limit of quantitation (LOQ = 0.009 μmol L-1). The biosensor that was developed can measure tryptophan (Trp) levels in the serum of both healthy individuals and female breast cancer patients with high accuracy and sensitivity. The results indicate that there is a significant difference, as shown by the F-test, between healthy individuals and those with breast cancer. This suggests that Trp amino acid could be an essential biomarker
for cancer diagnosis. Consequently, liquid biopsy analysis presents a valuable opportunity for early disease detection, particularly for cancer.

 

Research Authors
Fatma A. M. Abdel‑aal, Rania M. Kamel, Asmaa A. Abdeltawab, Fardous A. Mohamed, Abdel‑Maaboud I. Mohamed
Research Date
Research File
Research Image
Research Journal
Analytical and Bioanalytical Chemistry
Research Publisher
SpringerLink
Research Vol
415
Research Website
https://link.springer.com/article/10.1007/s00216-023-04784-7
Research Year
2023

Announcement for students of the fifth year of the Bachelor of Pharmacy program, Pharm-D. The periodic exam will be held for the course on quality control of pharmaceuticals.

God willing, the periodic exam for students in the fifth year of Pharm-D in the quality control of pharmaceuticals course will be held on Wednesday, April 3, 2024, at the time of the practical session (8-12) in the department’s laboratories.

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إعلانات الطلاب

The Scientific Conference of the Clinical Pharmacy Department, Faculty of Pharmacy on Wednesday, April 3, 2024, at twelve noon

God willing, the meeting of the department’s scientific conference will be held on the Clinical Pharmacy Department, Faculty of Pharmacy on Wednesday, April 3, 2024, at twelve noon at 12:00 AM

In the meetings Hall of the Department - 5th floor (Building A)

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خبر عام

Meeting of the Council of the Clinical Pharmacy Department, Faculty of Pharmacy will be held on Wednesday, April 3, 2024

God willing, the Clinical Pharmacy Department Council will hold its regular monthly meeting number (100) on Wednesday, April 3, 2024, at 11 :00 AM.

in the meetings Hall of the Department - 5th floor (Building A)

In the department council meeting room

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خبر عام

Meeting of the Council of the Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy on Wednesday, April 3, 2024

God willing, the Pharmaceutical Organic Chemistry Department Council will hold its regular monthly meeting number (475) This is on Wednesday, April 3, 2024, at 10:30 AM

In the department council meeting room.

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خبر عام
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