Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
301	6-Substituted 3,4-dihydro-naphthalene-2-carboxylic acids: synthesis and structure-activity studies in a novel class of human 5α reductase inhibitors,	2002
302	Kinetics of solid state stability of glycine derivatives as a model for peptides using differential scanning calorimetry.	2002
303	New 2H-Tetrahydro-1,3,5-thiadiazine-2-thiones Incorporating Glycine and Glycinamide as Potential Antifungal Agents.	2002
304	New 2H-Tetrahydro-1,3,5-thiadiazine-2-thiones Incorporating Glycine and Glycinamide as Potential Antifungal Agents.	2002
305	Synthesis and biological evaluation of 4-(4-alkyl- and Phenylaminocarbonyl)benzoyl)benzoic acid derivatives as nonsteroidal inhibitors of steroid 5α-reductase isozymes 1 and 2	2002
306	Synthsis of New Optically Active Thiadiazine-2-thione Derivatives as Antifungal Agents.	2002
307	Synthesis and antifungal activity of 3,3/-ethylenebis(5-alkyl-l,3,5- thiadiazine-2- thiones).	2001
308	Synthesis and Antifungal Activity of Some New 3,5-Disubstiuted Tetrahydro-2H-1,3,5-Thiadiazine-2-Thione.	2001
309	Investigation of Alkylating, Antineoplastic and Anti-HIV Potentials of the Chalcones; 2-(3-Arylpropenoyl)benzimidazole and Their Corresponding N1-Methyl Derivatives.	2000
310	New chiral amine ligands for enantioselective synthesis of certain (S)- and (R)-monobactams.	2000