Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
1	Fatty Acid Conjugated Chalcones as Tubulin Polymerization Inhibitors: Design, Synthesis, QSAR, and Apoptotic and Antiproliferative Activity	26/4/2023
2	Nature-inspired chalcone-functionalized paracetamol derivatives as potential anticancer leads: synthesis, biological evaluation, apoptotic mechanisms, and in silico docking studies	2026
3	Analysis of CD22 cis-ligands using a synthetic sialoside binding to CD22 with ultra-high affinity	2025
4	CDK2 Inhibitors: Rationally Directed Discovery of a Novel Potent Lead derived from Cyclohepta[e]thieno[2,3-b]pyridine	2025
5	Design, synthesis, and antiproliferative activity of new 2-amino-pyrano[3,2-c]quinoline-3- carbonitriles as potential EGFR, BRAFV600E, and HER-2 inhibitors	2025
6	Design, synthesis, and antiproliferative activity of new 5-ethylsulfonylindazole- 3-carbohydrazides as dual EGFR/VEGFR-2 kinases inhibitors	2025
7	Design, Synthesis, and Antiproliferative Activity of Novel Indole/1,2,4-Triazole Hybrids as Tubulin Polymerization Inhibitors	2025
8	Design, Synthesis, and Biological Evaluation of Novel Benzimidazole/Schiff Base Hybrid Derivatives With Potential Biological Activities	2025
9	Design, synthesis, and characterization of novel 5- ethylsulfonyl-indazole-3-carboxamides as dual VEGFR-2 and EGFR inhibitors: apoptotic antiproliferative and immunomodulatory evaluations	2025
10	Design, synthesis, and computational studies of novel pyrazoline-based dual EGFR/HER-2 inhibitors with apoptotic antiproliferative activity	2025