Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
51	New nitazoxanide derivatives: design, synthesis, biological evaluation, and molecular docking studies as antibacterial and antimycobacterial agents	2023
52	Novel fluoroquinolone hybrids as dual DNA gyrase and urease inhibitors with potential antibacterial activity: Design, synthesis, and biological evaluation	2023
53	Novel piperine carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway	2023
54	Phytochemical analysis and anti-infective potential of fungal endophytes isolated from Nigella sativa seeds	2023
55	Synthesis and antiproliferative Potential of thiazole and 4-thiazolidinone Containing Motifs as dual inhibitors of EGFR and BRAFV600E	2023
56	Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl) Quinolin-2(1H)-Ones as Multi-Target Inhibitors	2023
57	Synthesis, biological evaluation and molecular docking study of some new 4-aminosalicylic acid derivatives as anti-inflammatory and antimycobacterial agents	2023
58	Synthesis, Characterization, Antibacterial Evaluation, and Insecticidal Activity of Some Heterocyclic Compounds Containing Styrylpyridine Moiety	2023
59	The design, synthesis, biological evaluation, and molecular docking of new 5-aminosalicylamide-4-thiazolinone hybrids as anticancer agents	2023
60	Wound healing potential of Narcissus pseudonarcissus L. bulbs supported with chemical and molecular docking investigations	2023