Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
91	Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity	2021
92	Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors	2021
93	Development of new hetero‑steroid hybrids with antiproliferative activity against MCF‑7 breast cancer cells	2021
94	Enhanced molecular imprinted electrochemical sensing of histamine based on signal reporting nanohybrid	2021
95	FAK inhibitors as promising anticancer target: Present ‎and future directions	2021
96	Globally approved EGFR inhibitors: insights into their syntheses, targeted kinases, biological activity, receptor interactions and metabolism	2021
97	New quinoline/1,2,4-triazole hybrids as dual inhibitors of COX-2/5-LOX and inflammatory cytokines: Design, synthesis, and docking study	2021
98	Novel 1,2,4-oxadiazole/pyrrolidine hybrids as DNA gyrase and Topoisomerase IV inhibitors with potential antibacterial activity	2021
99	Novel Urea Linked Ciprofloxacin-Chalcone Hybrids having Antiproliferative Topoisomerases I/II Inhibitory Activities and Caspases-Mediated Apoptosis	2021
100	Novel Urea Linked Ciprofloxacin-Chalcone Hybrids having Antiproliferative Topoisomerases I/II Inhibitory Activities and Caspases-Mediated Apoptosis	2021