Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
91	Globally approved EGFR inhibitors: insights into their syntheses, targeted kinases, biological activity, receptor interactions and metabolism	2021
92	New quinoline/1,2,4-triazole hybrids as dual inhibitors of COX-2/5-LOX and inflammatory cytokines: Design, synthesis, and docking study	2021
93	Novel 1,2,4-oxadiazole/pyrrolidine hybrids as DNA gyrase and Topoisomerase IV inhibitors with potential antibacterial activity	2021
94	Novel Urea Linked Ciprofloxacin-Chalcone Hybrids having Antiproliferative Topoisomerases I/II Inhibitory Activities and Caspases-Mediated Apoptosis	2021
95	Novel Urea Linked Ciprofloxacin-Chalcone Hybrids having Antiproliferative Topoisomerases I/II Inhibitory Activities and Caspases-Mediated Apoptosis	2021
96	Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2	2021
97	Synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors	2021
98	Synthesis, Characterization, and Antifungal Activity of Some New Thieno[2,3-b]pyridines Incorporating Quinazoline or Benzimidazole Moiety	2021
99	The protein tyrosine phosphatase SHP-1 (PTPN-6) but not CD45 (PTPR-C) is essential for the ligand-mediated regulation of CD22 in BCR-ligated B cells	2021
100	A Facile Synthesis, Drug‑Likeness, and In Silico Molecular Docking of Certain New Azidosulfonamide–Chalcones and Their In Vitro Antimicrobial Activity	2020