Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
101 Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2 2021
102 Synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors 2021
103 Synthesis, Characterization, and Antifungal Activity of Some New Thieno[2,3-b]pyridines Incorporating Quinazoline or Benzimidazole Moiety 2021
104 The protein tyrosine phosphatase SHP-1 (PTPN-6) but not CD45 (PTPR-C) is essential for the ligand-mediated regulation of CD22 in BCR-ligated B cells 2021
105 A Facile Synthesis, Drug‑Likeness, and In Silico Molecular Docking of Certain New Azidosulfonamide–Chalcones and Their In Vitro Antimicrobial Activity 2020
106 A Hybrid In Silico/In Vitro Target Fishing Study to Mine
Novel Targets of Urolithin A and B: A Step Towards a Better
Comprehension of Their Estrogenicity 		2020
107 Antimicrobial Pyridazines: Synthesis, Characterization, Cytotoxicity, Substrate Promiscuity, and Molecular Docking 2020
108 CK2 Inhibition, Lipophilicity and Anticancer Activity of New N1 Versus N2-Substituted Tetrabromobenzotriazole Regioisomers 2020
109 CK2 Inhibition, Lipophilicity and Anticancer Activity of New N1 Versus N2-Substituted Tetrabromobenzotriazole Regioisomers 2020
110 Click chemistry synthesis, biological evaluation and docking study of some novel 2′-hydroxychalcone-triazole hybrids as potent anti-inflammatory agents. 2020