Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
131	Synthesis and characterization of some new pyridines, thieno[2,3-b] pyridines and pyrido[3',2'-4,5]thieno[3,2-d]pyrimidine-4(3H)-ones bearing styryl moiety	2020
132	Synthesis and characterization of some new S-substituted sulfanylpyridines, thieno[2,3-b]pyridines and related heterocycles	2020
133	Synthesis of some new 1,2-disubstituted-1,2,4-triazolobenzimidazoles with antifungal and anti-inflammatory effects.	2020
134	Aryl Azide-Sulfonamide Hybrids Induce Cellular Apoptosis: Synthesis and Preliminary Screening of Their Cytotoxicity in Human HCT116 and A549 Cancer Cell Lines	2019
135	Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities	2019
136	Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types	2019
137	Novel Quinoline Derivatives Carrying Nitrones/Oximes Nitric Oxide Donors: Design, Synthesis, Antiproliferative and Caspase-3 Activation Activities	2019
138	Self-Assembled Tannic Acid Complexes for pH-Responsive Delivery of Antibiotics: Role of Drug-Carrier Interactions	2019
139	Stereoselective trimethylsilylation of α- and β-galactopyranoses	2019
140	Synthesis and Anti-HSV Activity of Tricyclic Penciclovir and Hydroxybutylguanine Derivatives	2019