Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
171	Design and Synthesis of Novel 5-Aminosalicylate (5-ASA)–4-Thiazolinone Hybrid Derivatives with Promising Antiproliferative Activity	2016
172	Design and Synthesis of Novel 5-Aminosalicylate (5-ASA)–4-Thiazolinone Hybrid Derivatives with Promising Antiproliferative Activity	2016
173	Design and Synthesis of Novel 5-Aminosalicylate (5-ASA)–4-Thiazolinone Hybrid Derivatives with Promising Antiproliferative Activity	2016
174	Design and Synthesis of Some Substituted Thiazolo[3,2-a]Pyrimidine Derivatives of Potential Biological Activities	2016
175	Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors	2016
176	Nature-Inspired Design of Tetraindoles: Optimization of the Core Structure and Evaluation of Structure–Activity Relationship	2016
177	Synthesis and Pharmacokinetic studies of Effective and Safe New Antimicrobial Derivatives of Substitited Hydroquinoxaline-2,3-diones	2016
178	Synthesis and Preliminary Biological Screening of 6-Aminopyrazolo[3,4-b]pyridine Derivatives	2016
179	Synthesis of B- and C-Ring-Modified Lithocholic Acid Analogues as Potential Sialyltransferase Inhibitors	2016
180	Synthesis Of New 4-Aminosalicylates-, Triazole- and Hydrazide-Based Conjugates With Potential Anti-Tubercular Activity.	2016