Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
201 Synthesis Of New 4-Aminosalicylates-, Triazole- and Hydrazide-Based Conjugates With Potential Anti-Tubercular Activity. 2016
202 Synthesis of Some Benzimidazole Derivatives Endowed with 1,2,3-Triazole as Potential Inhibitors of Hepatitis C Virus 2016
203 Synthesis of Some Benzimidazole Derivatives Endowed with 1,2,3-Triazole as Potential Inhibitors of Hepatitis C Virus 2016
204 Synthesis, Molecular Modeling Study and Anti-inflammatory Activity of
Novel Benzimidazole Derivatives with Promising Cyclooxygenase Inhibitory
Properties 		2016
205 Synthesis, Molecular Modeling Study and Anti-inflammatory Activity of
Novel Benzimidazole Derivatives with Promising Cyclooxygenase Inhibitory
Properties 		2016
206 Synthesis, Molecular Modeling Study and Anti-inflammatory Activity of
Novel Benzimidazole Derivatives with Promising Cyclooxygenase Inhibitory
Properties 		2016
207 Synthesis, Molecular Modeling Study and Anti-inflammatory Activity of
Novel Benzimidazole Derivatives with Promising Cyclooxygenase Inhibitory
Properties 		2016
208 A-ring Substituted 17 β-Arylsulfonamides of 17β-Aminoestra-1,3,5(10)-trien-3-ol as Highly Potent Reversible Inhibitors of Steroid Sulfatase 2015
209 Crystal structure of methyl 2-hydroxy-5-[(4-oxo-4,5-
dihydro-1,3-thiazol-2- yl)amino]benzoate
 		2015
210 Synthesis and biological evaluation of cystobactamid 507: A bacterial topoisomerase inhibitor from Cystobacter sp. 2015