Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
211	Expanding the scaffold for bacterial RNA polymerase inhibitors: Design, synthesis and structure activity relationships of ureido-heterocyclic-carboxylic acids	2014
212	Facile Synthesis, Molecular Docking, and Biological Screening of 1,3-Disubstituted Urea Derivatives	2014
213	In Silico Studies of Quinoxaline-2-Carboxamide 1,4-di-N-Oxide Derivatives as Antimycobacterial Agents	2014
214	Surface plasmon resonance – more than a screening technology: insights in the binding mode of σ70:core RNAP inhibitors	2014
215	Synthesis and Characterization of bis-3,5-Disubstituted Thiadiazine-2-thione Derivatives as Anticancer Agents	2014
216	A Combined Experimental Green Flow-Injection Procedure and Computational Analysis to Determine Amino Acids	2013
217	Assessment of New Anti-HER2 Ligands Using Combined Docking, QM/MM Scoring and MD Simulation	2013
218	Design, Synthesis and Molecular Docking of Some New 1,2,4-Triazolobenzimidazol-3-yl Acetohydrazide Derivatives with Anti-Inflammatory-Analgesic Activities	2013
219	Design, Synthesis and Molecular Docking of Some New 1,2,4-Triazolobenzimidazol-3-yl Acetohydrazide Derivatives with Anti-Inflammatory-Analgesic Activities	2013
220	Design, Synthesis and Molecular Docking of Some New 1,2,4-Triazolobenzimidazol-3-yl Acetohydrazide Derivatives with Anti-Inflammatory-Analgesic Activities	2013