Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
211	Synthesis and investigation of antihypertensive activity using anaesthetized normotensive nonhuman primates of some 2-aryl-4-(substituted) pyrimido[1,2-a] benzimidazoles	2015
212	Synthesis, anti-inflammatory and molecular docking of some new 1,2,4-triazolobenzimidazol-3-yl acetone thiosemicarbazone cyclized derivatives as PLA-2 inhibitors	2015
213	Synthesis, anti-inflammatory and molecular docking of some new 1,2,4-triazolobenzimidazol-3-yl acetone thiosemicarbazone cyclized derivatives as PLA-2 inhibitors	2015
214	Synthesis, anti-inflammatory and molecular docking of some new 1,2,4-triazolobenzimidazol-3-yl acetone thiosemicarbazone cyclized derivatives as PLA-2 inhibitors	2015
215	Synthesis, anti-inflammatory and molecular docking of some new 1,2,4-triazolobenzimidazol-3-yl acetone thiosemicarbazone cyclized derivatives as PLA-2 inhibitors	2015
216	Design and Synthesis of New (SecinH3) Derivatives as Potential Cytohesin Inhibitors	2014
217	Design and synthesis of new pyrido[2,3-d]pyrimidine-1,4-dione derivatives as anti-inflammatory agents	2014
218	Design and Synthesis of Some New Purine-dione Derivatives of Potential Anti- inflammatory Activity	2014
219	Discovery of New HER2/EGFR Dual Kinase Inhibitors Based on the Anilinoquinazoline Scaffold as Potential Anti-Cancer Agents	2014
220	Expanding the scaffold for bacterial RNA polymerase inhibitors: Design, synthesis and structure activity relationships of ureido-heterocyclic-carboxylic acids	2014