Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
151	Synthesis and Anti-HSV Activity of Tricyclic Penciclovir and Hydroxybutylguanine Derivatives	2019
152	Synthesis and Anti-HSV Activity of Tricyclic Penciclovir and Hydroxybutylguanine Derivatives	2019
153	Synthesis and Anti-HSV Activity of Tricyclic Penciclovir and Hydroxybutylguanine Derivatives	2019
154	Thiohydantoin Derivatives Incorporating A Pyrazole Core: Design, Synthesis and Biological Evaluation as Dual Inhibitors of Topoisomerase-I and Cycloxygenase-2 with Anti-Cancer and Anti-Inflammatory Activities	2019
155	Bis-(5-substituted-2-thiono-1,3,5-thiadiazinan-3-yl) Butane as a Scaffold of Anti-Proliferative Activity, Blended by a Multicomponent Process	2018
156	CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand- Dependent and Independent Pathways and Enhance Antibody Production in Mice	2018
157	Design, Synthesis, Mechanistic and Histopathological Studies of Small-Molecules of Novel Indole-2-Carboxamides and Pyrazino[1,2-a]indol-1(2H)-ones as Potential Anticancer Agents Effecting the Reactive Oxygen Species Production	2018
158	Design, Synthesis, Mechanistic and Histopathological Studies of Small-Molecules of Novel Indole-2-Carboxamides and Pyrazino[1,2-a]indol-1(2H)-ones as Potential Anticancer Agents Effecting the Reactive Oxygen Species Production	2018
159	Modified Lidocaine Derivatives as a Potential Inhibitors of Eosinophils	2018
160	Modified Lidocaine Derivatives as a Potential Inhibitors of Eosinophils	2018