Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

# Title Research Year
141 Solvent-Free N‑Formylation: An Experimental Application of Basic Concepts and Techniques of Organic Chemistry
 		2020
142 Synthesis and characterization of some new pyridines, thieno[2,3-b] pyridines and pyrido[3',2'-4,5]thieno[3,2-d]pyrimidine-4(3H)-ones bearing styryl moiety 2020
143 Synthesis and characterization of some new S-substituted sulfanylpyridines, thieno[2,3-b]pyridines and related heterocycles 2020
144 Synthesis of some new 1,2-disubstituted-1,2,4-triazolobenzimidazoles with antifungal and anti-inflammatory effects. 2020
145 Aryl Azide-Sulfonamide Hybrids Induce Cellular Apoptosis: Synthesis and Preliminary Screening of Their Cytotoxicity in Human HCT116 and A549 Cancer Cell Lines 2019
146 Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities 2019
147 Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types 2019
148 Novel Quinoline Derivatives Carrying Nitrones/Oximes Nitric Oxide Donors: Design, Synthesis, Antiproliferative and Caspase-3 Activation Activities 2019
149 Self-Assembled Tannic Acid Complexes for pH-Responsive Delivery of Antibiotics: Role of Drug-Carrier Interactions 2019
150 Stereoselective trimethylsilylation of α- and β-galactopyranoses 2019