Department Researches & Publications

Department of Pharmaceutical Organic Chemistry

Research

Our researches Plan:

1- Development, study in depth of pharmaceutical organic chemistry and illustration of its synthetic, mechanistic, and industrial applications.

2- Design and synthesis of different classes of compounds such as: Triazoles, benzimidazoles, piperazinedione and thiadiazine derivatives and others A special focus on xanthine and pyridazinone derivatives

3- Structural elucidation of the target compounds utilizing: IR,1H-NMR, MS in addition to elemental analysis Optical Rotation

4- Biological screening: Antimicrobial: antibacterial, antifungal and antituberculosis in addition to anthlemintic activity. Anti-inflammatory, analgesic, antipyretic activities and ulcerogenicity determination. Cardiotonic and hypotensive activities. Hypoglycemic activity. Anticonvulsant activity.

5- Other titles in consideration: Synthesis of new dendimers of potential biological activity. Applications of photochemical reactions for synthesis of certain organic compounds of potential biological activity. Synthesis of some antineurodegenerative compounds. Synthesis of certain nucleosides of potential biological activity. Synthesis of certain adenine derivatives of possible antiviral activity.

#	Title	Research Year
141	Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities	2019
142	Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types	2019
143	Novel Quinoline Derivatives Carrying Nitrones/Oximes Nitric Oxide Donors: Design, Synthesis, Antiproliferative and Caspase-3 Activation Activities	2019
144	Self-Assembled Tannic Acid Complexes for pH-Responsive Delivery of Antibiotics: Role of Drug-Carrier Interactions	2019
145	Stereoselective trimethylsilylation of α- and β-galactopyranoses	2019
146	Synthesis and Anti-HSV Activity of Tricyclic Penciclovir and Hydroxybutylguanine Derivatives	2019
147	Synthesis and Anti-HSV Activity of Tricyclic Penciclovir and Hydroxybutylguanine Derivatives	2019
148	Synthesis and Anti-HSV Activity of Tricyclic Penciclovir and Hydroxybutylguanine Derivatives	2019
149	Thiohydantoin Derivatives Incorporating A Pyrazole Core: Design, Synthesis and Biological Evaluation as Dual Inhibitors of Topoisomerase-I and Cycloxygenase-2 with Anti-Cancer and Anti-Inflammatory Activities	2019
150	Bis-(5-substituted-2-thiono-1,3,5-thiadiazinan-3-yl) Butane as a Scaffold of Anti-Proliferative Activity, Blended by a Multicomponent Process	2018