Multidrug-resistant Acinetobacter baumannii, particularly strains that produce metallo-β-lactamase (MBL) and carbapenemase, are considered emerging infection control threats. Its antimicrobial resistance and ability to form biofilm make treatment difficult. Although early research suggests that vitamin C can break down biofilms and restore antibiotic activity, its efficacy against drug-resistant A. baumannii strains is still unclear. The aim of this study was to assess the antimicrobial and biofilm inhibition properties of vitamin C against drug-resistant A. baumannii strains. 

Fifty clinical isolates of A. baumannii were collected from Assiut University Hospitals, Egypt. PCR detection of blaOXA-51-like gene was used for species confirmation. Antimicrobial susceptibility testing, β-lactamase phenotyping, and biofilm-forming assay were conducted. Broth microdilution was used to determine vitamin C …