Uptake of radiodine by thyroid glan within 90 min after I.v injection with Na 131 I was studied in male rats which had been i.p injected with either PGB1, PGF1α or PGF2α. The mathematical analysis of radioiodide plasma disappearance curves showed that the rioiodide was kinetically exchanged within a two compartmental model. This is one of the three compartmental model of Wollman and Reed in which total 131 I is considered to be one compartment and blood plasma is the other. The fraction rate constant for migration of 131I from plasma pool towards the reversible pool of the thyroid was effectively enhanced by PGF1α and PGF2α . The reversible fractional rate constant was variably affected. The fractional rate constant that regulates the interconversion of free iodide from labile pool to be oxidized is increased due to the action of PGF1α and decreased by PGF2α.

Released T4 and T3 hormones in albino rat blood after an exogenous administration of PGB1, PG1α and PGF2α were determined and correlated with the serum content of calcium. Results revealed that all the tested PGs significantly raised the levels of T3 and T4 in rat serum, but not affect the serum calcium levels. PGB1 and PGF1α reduced the thyroidal calcium content due to enhancing the ellular permeability. However, the effect of PGF2α due to enhancing the lysosomal proteolytic enzyme activity.

Oxidative stress induced hyperglycemia plays a central role in the pathogenesis of diabetes and its complications in most of the tissues. In the present study the protective roles of lipoic acid and n-acetylcysteine for the treatment of oxidative stress in alloxan-induced diabetic rabbits were studied. The obtained results concluded that lipoic acid or N-acetylcystiene my be hseful for the therapy of oxidative stress associated with hyperglycemia. The beneficial action seems to result mainly from direct scavenging of ROS and restoring glutathione redox state.

The experiment was designed to investigate the role of tannic acid as antioxidant in reduction of the oxidtive damage of ALCL3 in the brin of rat The obtained biochemical and histological results documentd that tannic acid has a prophylactic role in reducing the oxidaive amage in the bain tissues that caused by ALCL3 exposure for80 days in drinking water.

Pospectiv studies suggest that tea may protect against oxidative stress that induced tissue damage. A potential mechanism fr such effect y polyphenolc antioxidant tannic acid derived from tea was evaluated in tis study. Treatment of rats with ALCL3 for 80 days caused moderate toxicity on liver, kidney and splen as evidenced by increased LPO& No and a reduction of SOD,CAT, GST, GSH nd vitamin E.As well as histopathological changes.However improvement was noticed in the rats treated with tannic acid.

During the late pregnancy and during parturition in bovine, sevearl hormones and reoxygenation of placental tissues and consequences oxidative stress were involved. In this study blood samples from pregnant cows in the last three weeks of pregnancy were taken. At parturition 10 animals were selected as normal parturition and non-retaind placental expulsion. Other 10 cows were selected with normal parturition and retaind placenta. Another blood samples were taken after 1, 24 and 48 hours postpartum from both the obivois groups. The study concluded that oxidative stress and cortisol hormone might play an important role in the process of parturition in cows. It was also found that the extra-elevation of the LPO, NO and cortisol and the reduction of antioxidants could be used as indictor for the possibility of retention of fetal membrane after parturition.

During the late pregnancy and during parturition in bovine, sevearl hormones and reoxygenation of placental tissues and consequences oxidative stress were involved. In this study blood samples from pregnant cows in the last three weeks of pregnancy were taken. At parturition 10 animals were selected as normal parturition and non-retaind placental expulsion. Other 10 cows were selected with normal parturition and retaind placenta. Another blood samples were taken after 1, 24 and 48 hours postpartum from both the obivois groups. The study concluded that oxidative stress and cortisol hormone might play an important role in the process of parturition in cows. It was also found that the extra-elevation of the LPO, NO and cortisol and the reduction of antioxidants could be used as indictor for the possibility of retention of fetal membrane after parturition.

The present study found that antioxidant and the changes in LPO and NO levels were subjected to marked changes in the course of follicular growth during luteal phase of estrous cycle in buffalo-cows. These changes in the intra-folicular environment may reflect the follicular requirements for growth, maturation and maintenance of viability of oocyte in buffalo-cows.

The study found that the use of BAL and DMPS as chelating agents after long-term of mercuric exposure resulted in considerable recovery in the histopathological, hematological. and biochemical alteration that induced by mercury. However, DMPS has a relative better effect due to its water solubility, less toxicity and its ability to chelate with more metal ions.

The study found that the use of BAL and DMPS as chelating agents after long-term of mercuric exposure resulted in considerable recovery in the histopathological, hematological. and biochemical alteration that induced by mercury. However, DMPS has a relative better effect due to its water solubility, less toxicity and its ability to chelate with more metal ions.