Oxidative stress has been proven to be involved in cisplatin (CP)-induced toxicity. The present study was designed to evaluate the antioxidant activity of Vit C, N,N0-diphenyl-p-phenylenediamine (DPPD) and Lcysteine against CP-induced testicular oxidative damage in rats. Our data indicated significant increases in lipid peroxides (LPO), total peroxides and superoxide anion levels in testes of rats treated with CP (2 mg/kg/week, for 4 weeks) that was associated with a significant reduction in the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST). The contents of glutathione (GSH), Vit E and Vit C were significantly lower in CP treated testes compared with these of control. The co-administration of CP with DPPD or L-cysteine significantly reduced the elevation in LPO, however the co-administration of CP with Vit C, DPPD or L-cysteine reduced the effect of CP on superoxide anion and antioxidant enzymes and also on the antioxidants contents. The administration of Vit C, DPPD or L-cysteine before CP injection improved the histological pictures and reduced the number of apoptotic cells and DPPD was more efficient. In conclusion, DPPD is a potent antioxidant, against CP-induced testicular oxidative damage, as compared with Vit C and L-cysteine

The experiment was designed to evaluate the role of garlic oil which contain high contens of sulphur componds for the control of blood glucose levels and oxidative stress that induced in rats by alloxan. The study conclude that garlic oil has the capacity to ameliorate the oxidative stress by increasing the antioxidant contens and reduced the free radicals production. Also, control the blood glucose levels may be by mechanism id dependt on insluin.

In this paper, Appell’s matrix function of two complex variables is introduced, starting from the hypergeometric matrix function with the studies of the properties and an elementary generating functions for Jacobi matrix polynomials are obtained.

Cisplatin is one of the most widely used cytotoxic therapeutic agents for the treatment of cancer. This drug, at effective higher doses or multiple low doses, causes many physiological adverse effects. N,N Diphenyl-р-phenylenediamine (DPPD) and Vit C against cisplatin-induced oxidative stress in rats. Cisplatin was injected once a week (2 mg/kg bwt) for 4 weeks. DPPD (125 mg/kg bwt) and vit C (100 mg/kg bwt) were injected once a week an 24 hour prior to cisplatin injection. In cisplatin treated group, the number of RBCs and WBCs were decreased (P 0.05) compared to that of control rats. However, in rats injected with Vit C or DPPD prior to cisplatin treatment, blood cells counts elevated again to their normal values. Cisplatin toxicity was manifested biochemically by a significant increase (P0.05) of LPO in spleen as well as a decrease in GSH content which associated with a reduction in the activities of antioxidant enzymes, SOD, CAT, GST and γ GGT in spleen and plasma. In addition to the marked decrease in Vit C and Vit E levels. In rats treated with Vit C or DPPD in combination with cisplatin LPO and the activities of SOD, GST, CAT and GGT restored to about normal control levels. In conclusion DPPD and vitamin C are efficient promising compounds for reducing cisplatin-toxic side effects.

serum levels of GH, Somatomedin-C as well as linear body growth were determined in 28 young diabetic subjects (14 children and 14 preadolescents) and in 20 normal age-matched control. All children and 50% of the preadolescent patients were poorly controlled. The mean hight in both groups was insignificantly lower than that in controls. Serum GH was higher in both groups while SM-C was insignificantly lower in children and insignificantly higher in preadolescents than that in the controls. An inverse correlation between GPP and SM-C in the poorly controlled preadolescent diabetics. These finding may suggest that the decreased linear growth results in poorly controlled diabetics from decreased serum SM-C. Meanwhile, the elevated GH levels may imply a state of GH resistance and may help to explain the inadequate diabetes control among this group patients.

serum levels of GH, Somatomedin-C as well as linear body growth were determined in 28 young diabetic subjects (14 children and 14 preadolescents) and in 20 normal age-matched control. All children and 50% of the preadolescent patients were poorly controlled. The mean hight in both groups was insignificantly lower than that in controls. Serum GH was higher in both groups while SM-C was insignificantly lower in children and insignificantly higher in preadolescents than that in the controls. An inverse correlation between GPP and SM-C in the poorly controlled preadolescent diabetics. These finding may suggest that the decreased linear growth results in poorly controlled diabetics from decreased serum SM-C. Meanwhile, the elevated GH levels may imply a state of GH resistance and may help to explain the inadequate diabetes control among this group patients.