The complexes [Ni{(RO)2PS2}2Tsc], [Ni{(RO)2PS2}2ApTsc], and [Ni{(RO) 2PS2}FurTsc.2H2O] where R = methyl (Me), ethyl (Et) or propyl (Prop); Tsc = thiosemicarbazide, ApTsc = 2-acetylpyridine- thiosemicarbazone, and FurTsc = furfuraldhydethiosemicarbazone have been synthesized and characterized by elemental analysis, conductance measurements, and spectral studies (IR, UV-Vis, and mass). Thermal studies of the complexes have been carried out using TG and DTG techniques. An octahedral structure has been proposed for all types of the complexes. A representative types of the complexes are tested against various pathogenic bacteria and fungi. The [Ni{(EtO)2PS2}2ApTsc] shows a high degree of activity against bacteria and fungi; this may be attributed to the pyridyl ring of the 2-acetylpyridinetluosemicarbazone ligand.

The complexes [Ni{(RO)2PS2}2Tsc], [Ni{(RO)2PS2}2ApTsc], and [Ni{(RO) 2PS2}FurTsc.2H2O] where R = methyl (Me), ethyl (Et) or propyl (Prop); Tsc = thiosemicarbazide, ApTsc = 2-acetylpyridine- thiosemicarbazone, and FurTsc = furfuraldhydethiosemicarbazone have been synthesized and characterized by elemental analysis, conductance measurements, and spectral studies (IR, UV-Vis, and mass). Thermal studies of the complexes have been carried out using TG and DTG techniques. An octahedral structure has been proposed for all types of the complexes. A representative types of the complexes are tested against various pathogenic bacteria and fungi. The [Ni{(EtO)2PS2}2ApTsc] shows a high degree of activity against bacteria and fungi; this may be attributed to the pyridyl ring of the 2-acetylpyridinetluosemicarbazone ligand.

Mixed ligand complexes of Zn(II) and Cd(II) containing ceftriaxone (Naceftria) or cephradine (Hcefphr) antibiotics and other ligands have been prepared and characterized by elemental analysis, spectral, biological and thermal studies. The complexes have the general formulae: [Zn(ceftria)(diamine)(OAc)].xH 2O, [Cd(ceftria)(diamine)Cl(H 2O)].xH 2O, [M(ceftria) (L)(H 2O) 2].xH 2O, [Cd 2(cephr)(diamine)Cl 3(H 2O)].xH 2O, [Cd 3(cephr)(μ-HL)Cl 5(H 2O)].2H 2O where diamine= 2,2'-bipyridyl or o-phenanthroline; M= Cd(II) or Zn(II), L= glycine, proline or methionine and x=0-6. Ceftriaxone chelates to the metal ions as a bidentate monoanion ligand through the β-lactam carbonyl and carboxylate group. On the other hand, cephradine coordinates to Cd(II) ions as a uninegative tetradentate NOON ligand via the carboxylate oxygen, β-lactam nitrogen besides the carbonyl oxygen and the amino nitrogen of the side chain amide group. Regarding the amino acids, it was found that they coordinate bidentately through NH 2 and COO - groups in the case of cefriaxone complexes. In case of Cd-cephradine-amino acid complexes the amino acids act as μ-O,O bridging ligands.

Mixed ligand complexes of Zn(II) and Cd(II) containing ceftriaxone (Naceftria) or cephradine (Hcefphr) antibiotics and other ligands have been prepared and characterized by elemental analysis, spectral, biological and thermal studies. The complexes have the general formulae: [Zn(ceftria)(diamine)(OAc)].xH 2O, [Cd(ceftria)(diamine)Cl(H 2O)].xH 2O, [M(ceftria) (L)(H 2O) 2].xH 2O, [Cd 2(cephr)(diamine)Cl 3(H 2O)].xH 2O, [Cd 3(cephr)(μ-HL)Cl 5(H 2O)].2H 2O where diamine= 2,2'-bipyridyl or o-phenanthroline; M= Cd(II) or Zn(II), L= glycine, proline or methionine and x=0-6. Ceftriaxone chelates to the metal ions as a bidentate monoanion ligand through the β-lactam carbonyl and carboxylate group. On the other hand, cephradine coordinates to Cd(II) ions as a uninegative tetradentate NOON ligand via the carboxylate oxygen, β-lactam nitrogen besides the carbonyl oxygen and the amino nitrogen of the side chain amide group. Regarding the amino acids, it was found that they coordinate bidentately through NH 2 and COO - groups in the case of cefriaxone complexes. In case of Cd-cephradine-amino acid complexes the amino acids act as μ-O,O bridging ligands.

Mixed ligand complexes of Zn(II) and Cd(II) containing ceftriaxone (Naceftria) or cephradine (Hcefphr) antibiotics and other ligands have been prepared and characterized by elemental analysis, spectral, biological and thermal studies. The complexes have the general formulae: [Zn(ceftria)(diamine)(OAc)].xH 2O, [Cd(ceftria)(diamine)Cl(H 2O)].xH 2O, [M(ceftria) (L)(H 2O) 2].xH 2O, [Cd 2(cephr)(diamine)Cl 3(H 2O)].xH 2O, [Cd 3(cephr)(μ-HL)Cl 5(H 2O)].2H 2O where diamine= 2,2'-bipyridyl or o-phenanthroline; M= Cd(II) or Zn(II), L= glycine, proline or methionine and x=0-6. Ceftriaxone chelates to the metal ions as a bidentate monoanion ligand through the β-lactam carbonyl and carboxylate group. On the other hand, cephradine coordinates to Cd(II) ions as a uninegative tetradentate NOON ligand via the carboxylate oxygen, β-lactam nitrogen besides the carbonyl oxygen and the amino nitrogen of the side chain amide group. Regarding the amino acids, it was found that they coordinate bidentately through NH 2 and COO - groups in the case of cefriaxone complexes. In case of Cd-cephradine-amino acid complexes the amino acids act as μ-O,O bridging ligands.

4-Amino-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide (5), which was synthesized by an innovative method, was used as a versatile precursor for synthesizing pyrazolothienopyrimidines and imidazopyrazolothienopyrimidines compounds. Reaction of amino thienopyrazole carboxamide 5 with triethyl orthoformate afforded thienopyrazolopyrimidine 6. Chlorination of the latter compound, using phosphorus oxychloride afforded the chloro pyrazolothienopyrimidine 7, which underwent nucleophilic substitution reactions with various primary and secondary amines to give the alkyl (aryl) amino pyrimidine compounds 8a-d. On the other hand, the reaction of chloropyrimidine 7 with thiourea afforded the pyrimidine thione compound 9, which was alkylated with -halogentaed compounds to afford the S-alkylated derivatives 10a-c. Also, chloroacetylation of the amino carboxamide 5 using chloroacetyl chloride yielded the chloromethyl pyrazolothienopyrimidine 12, which underwent nucleophilic substitution reactions with various primary and secondary amines to afford the alkyl (aryl) aminomethyl compounds 13a-f. The latter Compounds underwent Mannich reaction to give imidazopyrimidothienopyrazoles 14a-c. The newly synthesized compounds and their derivatives were fully characterized by elemental and spectral analysis.