There is a growing interest for the utilization of microalgae in the bioremediation of organic pollutants and the use of biomass as a biofuel feedstock. This study investigated the influence of phenol exposure and culture conditions on the phenol removal efficiency, biomass productivity and lipid contents of Tetradesmus obliquus. Plackett-Burman design identified CaCl₂, NaNO₃, and initial phenol concentration as the most important variables affecting on phenol removal. The optimum conditions to maximize biomass productivity, phenol removal and lipid content were determined using the Box-Behnken experimental design as 150.1 mg L⁻¹ phenol, 0.1 g L⁻¹ NaNO₃, and 0.03 g L⁻¹ CaCl₂. Under these conditions, phenol was completely removed from the optimized medium after 3 days and the biomass productivity and lipid content were 19.53 mg L⁻¹ day⁻¹ and 27.85% (w/w) after 10 days, respectively. Phenol treatment promoted algal biomass productivity to ∼1.3-folds and lipid productivity to ∼ 1.6-folds higher than the control treatment without adding phenol (negative control). Additionally, phenol altered the fatty acid methyl ester composition and increased the saturated and polyunsaturated fatty acid contents with concomitant decrease in the monounsaturated fatty acids. The predicted biodiesel characteristics viz. iodine value, cetane number, oxidation stability, kinematic viscosity, and flash point, in the presence of phenol were in accordance with the international standards. Accordingly, the present study indicated that phenol could be effectively bioremediated by T. obliquus with simultaneous promotion of the algal biomass and lipid productivity for biofuel production.

Electrode materials with high sensitivity and selectivity play a central role in the fabrication of electrochemical sensing platforms. In this work, functionalized graphitized carbon nanofibers (f-GCNFs)_core and nano-sized CeO₂ (nano-CeO₂)_shell was synthesized. The XRD, SEM, HRTEM and the EDX results confirmed the formation of the f-GCNFs@nano-CeO₂ core–shell nanocomposite. To construct the sensor, the graphite rod electrode (GRE) has been modified with f-GCNFs@nano-CeO₂. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) results revealed that the charge transfer on the f-GCNFs@nano-CeO₂/GRE was dramatically enhanced compared to the other electrodes. The prepared platform (f-GCNFs@nano-CeO₂) exhibited high electro-catalytic activity and the strong synergistic activity between f-GCNFs and nano-CeO₂ increased the electroactive surface area. The fabricated f-GCNFs@nano-CeO₂/GRE sensor has been utilized for the detection of the oxidative stress biomarker nitrotyrosine (NTyr) using SW-AdASV. The LOD and the LOQ are found to be 0.86 and 2.9 nM, respectively, with the dynamic range 2.0–1720 nM and sensitivity of 145 μAμM⁻¹ cm⁻². The developed sensor is highly selective for NTyr detection in the presence of uric acid (UA) and tyrosine (Tyr). Moreover, the fabricated sensor also shows good selectivity, favorable reproducibility, and long-term stability. The applicability of the fabricated sensor demonstrated excellent recovery of NTyr in spiked human serum, urine, and saliva samples. In the end, f-GCNFs@nano-CeO₂/GRE was applied to the determination of UA, NTyr, and Tyr simultaneously.

This work reports for the first spectrofluorimetric investigation of the INC280, Capmatinib (CAPM). The pho-
tophysical characteristics of CAPM especially fluorescence was extensively studied. CAPM has a native green
fluorescence at λem = 500 nm with λex = 250 nm, that could be influenced and optimized under various
experimental conditions of solvents, pH, temperature and inclusion matrices. Generally, protic polar alcoholic
solvents are the best solvents in sensitizing CAPM emission. Furthermore, addition of disodium hydrogen
phosphate aqueous solution of pH 6 at 25 ◦C reveals the highest fluorescence intensity of CAPM. Sodium dodecyl
sulfate (SDS) when added to CAPM in optimized concentration results in 81.4 % enhancement in the CAPM
fluorescence signal which impacted an improved sensitivity in the fluorimetric assaying of CAPM. HPLC-DAD
method was also applied for determination of cited drug. Native spectrofluorimetry and HPLC-DAD of CAPM
exhibits wide linear dynamic range from 0.015 to 2.0 μg/ mL and 0.02–100 μg/ mL within limits of detection of
0.0038 and 0.0039 μg/ mL, respectively. Moreover, the two methods are of high accuracy and precision that
reveal estimates of 93.16–100.91 % and 96.67–100.42 % for recovery % while the corresponding estimates of
RSD% ranges from 0.926 to 2.668 % and 0.505–1.571 %. The two methods were validated with successful
applicability in the assaying of spiked CAPM in human serum samples. Greenness characteristics for both
spectroflourimetric and HPLC-DAD methods were assessed using AGREE and GAPI approaches

An updated probabilistic seismic hazard analysis in terms of peak ground acceleration and spectral acceleration values, for B, B/C, and C NEHRP site classes, for a 5% and 10% probability of exceedance in 50 years, has been conducted for Western Mexico. To achieve this assessment, a unified and updated declustered earthquake catalog (1787–2019), as well as an updated focal mechanism database (1963–2016), was compiled, prepared, and processed specifically for this work. Two alternative source models (area sources and a spatially smoothed seismicity model) were considered in the assessment, within a logic tree scheme. A characteristic earthquake model has been also implemented for some of the defined sources. The designed logic tree has additionally included other parameters: the possible uncertainty related to the Gutenberg-Richter b-value way of estimation, the maximum expected magnitude value, as well as two-alternative GMPEs selected for the subduction seismic sources. The obtained ground-motion results have been presented as seismic hazard isoacceleration maps, as well as uniform hazard spectra and hazard curves for 15 selected cities, for the three considered site conditions. A comparison between the obtained hazard values and the current seismic design regulations, as well as previous studies, has been also performed, and a new design response spectrum has been proposed. Finally, some regression fitting relationships between the obtained ground-motion values have been achieved. Concerning the most significant results, it is worth noting that the southwestern coast (in the perimeter of the Middle America Trench of the Mexican Subduction Zone) presents the highest hazard values. For instance, the cities of Apatzingán, Autlán, Colima, Lázaro Cárdenas, and Manzanillo exhibit the largest observed PGA values among all the studied cities. Our approach and results are supported by the fact that the recent September 19, 2022, Mw 7.6 earthquake has been located in this highest seismic hazard area.