Yeasts are multilateral opportunistic plant symbionts that can cause intrinsic changes in the metabolism of host plants, thereby increasing plant growth and activating plant defense against various diseases. Although yeasts isolated from soil and plants have been evaluated as biological control agents, the search for new antagonists continues. Marine yeasts can be an option for the selection of new plant promoters and antagonistic agents. The objective of the present study was selected to demonstrate the potential of two marine yeast strains isolated from Red Sea water to award beneficial agronomic quality to promote wheat growth and induce defense mechanism against Fusarium oxysporum and its ability to produce zearalenone. These yeast strains were identified based on the genotypic identification as Candida orthopsilosis and Rhodotorula mucilaginosa, and their sequences were deposited