The complexes [Ni{(RO)2PS2}2Tsc], [Ni{(RO)2PS2}2ApTsc], and [Ni{(RO) 2PS2}FurTsc.2H2O] where R = methyl (Me), ethyl (Et) or propyl (Prop); Tsc = thiosemicarbazide, ApTsc = 2-acetylpyridine- thiosemicarbazone, and FurTsc = furfuraldhydethiosemicarbazone have been synthesized and characterized by elemental analysis, conductance measurements, and spectral studies (IR, UV-Vis, and mass). Thermal studies of the complexes have been carried out using TG and DTG techniques. An octahedral structure has been proposed for all types of the complexes. A representative types of the complexes are tested against various pathogenic bacteria and fungi. The [Ni{(EtO)2PS2}2ApTsc] shows a high degree of activity against bacteria and fungi; this may be attributed to the pyridyl ring of the 2-acetylpyridinetluosemicarbazone ligand.

The complexes [Ni{(RO)2PS2}2Tsc], [Ni{(RO)2PS2}2ApTsc], and [Ni{(RO) 2PS2}FurTsc.2H2O] where R = methyl (Me), ethyl (Et) or propyl (Prop); Tsc = thiosemicarbazide, ApTsc = 2-acetylpyridine- thiosemicarbazone, and FurTsc = furfuraldhydethiosemicarbazone have been synthesized and characterized by elemental analysis, conductance measurements, and spectral studies (IR, UV-Vis, and mass). Thermal studies of the complexes have been carried out using TG and DTG techniques. An octahedral structure has been proposed for all types of the complexes. A representative types of the complexes are tested against various pathogenic bacteria and fungi. The [Ni{(EtO)2PS2}2ApTsc] shows a high degree of activity against bacteria and fungi; this may be attributed to the pyridyl ring of the 2-acetylpyridinetluosemicarbazone ligand.

Mixed ligand complexes of Zn(II) and Cd(II) containing ceftriaxone (Naceftria) or cephradine (Hcefphr) antibiotics and other ligands have been prepared and characterized by elemental analysis, spectral, biological and thermal studies. The complexes have the general formulae: [Zn(ceftria)(diamine)(OAc)].xH 2O, [Cd(ceftria)(diamine)Cl(H 2O)].xH 2O, [M(ceftria) (L)(H 2O) 2].xH 2O, [Cd 2(cephr)(diamine)Cl 3(H 2O)].xH 2O, [Cd 3(cephr)(μ-HL)Cl 5(H 2O)].2H 2O where diamine= 2,2'-bipyridyl or o-phenanthroline; M= Cd(II) or Zn(II), L= glycine, proline or methionine and x=0-6. Ceftriaxone chelates to the metal ions as a bidentate monoanion ligand through the β-lactam carbonyl and carboxylate group. On the other hand, cephradine coordinates to Cd(II) ions as a uninegative tetradentate NOON ligand via the carboxylate oxygen, β-lactam nitrogen besides the carbonyl oxygen and the amino nitrogen of the side chain amide group. Regarding the amino acids, it was found that they coordinate bidentately through NH 2 and COO - groups in the case of cefriaxone complexes. In case of Cd-cephradine-amino acid complexes the amino acids act as μ-O,O bridging ligands.

Mixed ligand complexes of Zn(II) and Cd(II) containing ceftriaxone (Naceftria) or cephradine (Hcefphr) antibiotics and other ligands have been prepared and characterized by elemental analysis, spectral, biological and thermal studies. The complexes have the general formulae: [Zn(ceftria)(diamine)(OAc)].xH 2O, [Cd(ceftria)(diamine)Cl(H 2O)].xH 2O, [M(ceftria) (L)(H 2O) 2].xH 2O, [Cd 2(cephr)(diamine)Cl 3(H 2O)].xH 2O, [Cd 3(cephr)(μ-HL)Cl 5(H 2O)].2H 2O where diamine= 2,2'-bipyridyl or o-phenanthroline; M= Cd(II) or Zn(II), L= glycine, proline or methionine and x=0-6. Ceftriaxone chelates to the metal ions as a bidentate monoanion ligand through the β-lactam carbonyl and carboxylate group. On the other hand, cephradine coordinates to Cd(II) ions as a uninegative tetradentate NOON ligand via the carboxylate oxygen, β-lactam nitrogen besides the carbonyl oxygen and the amino nitrogen of the side chain amide group. Regarding the amino acids, it was found that they coordinate bidentately through NH 2 and COO - groups in the case of cefriaxone complexes. In case of Cd-cephradine-amino acid complexes the amino acids act as μ-O,O bridging ligands.

Mixed ligand complexes of Zn(II) and Cd(II) containing ceftriaxone (Naceftria) or cephradine (Hcefphr) antibiotics and other ligands have been prepared and characterized by elemental analysis, spectral, biological and thermal studies. The complexes have the general formulae: [Zn(ceftria)(diamine)(OAc)].xH 2O, [Cd(ceftria)(diamine)Cl(H 2O)].xH 2O, [M(ceftria) (L)(H 2O) 2].xH 2O, [Cd 2(cephr)(diamine)Cl 3(H 2O)].xH 2O, [Cd 3(cephr)(μ-HL)Cl 5(H 2O)].2H 2O where diamine= 2,2'-bipyridyl or o-phenanthroline; M= Cd(II) or Zn(II), L= glycine, proline or methionine and x=0-6. Ceftriaxone chelates to the metal ions as a bidentate monoanion ligand through the β-lactam carbonyl and carboxylate group. On the other hand, cephradine coordinates to Cd(II) ions as a uninegative tetradentate NOON ligand via the carboxylate oxygen, β-lactam nitrogen besides the carbonyl oxygen and the amino nitrogen of the side chain amide group. Regarding the amino acids, it was found that they coordinate bidentately through NH 2 and COO - groups in the case of cefriaxone complexes. In case of Cd-cephradine-amino acid complexes the amino acids act as μ-O,O bridging ligands.