Research Abstract
Chloroquine is a drug derived from cinchona bark has been
used for long time to treat different diseases including malaria and
accidently it was proved to lower hyperglycemia. Diabetes mellitus is
accompanied with many disorders including blood serum proteins
levels. Taking into consideration that insulin administration controls
hyperglycemia of diabetic patients but it is not sufficient to restore
the level of blood serum proteins. In the present work we compared
the action of chloroquine and insulin on major blood serum proteins
of alloxan induced diabetes. Mice were injected once with alloxan
and then treated either with chloroquine or insulin. Another category
of mice were fed with high glucose diet for short or long period to
induce hyperglycemia independent of insulin level. Major blood
serum proteins namely; transferrin, albumin, antitrypsin, acid
glycoprotein and immunoglobulin G were estimated by SDS-PAGE
and Image J software. Our results showed that chloroquine and
insulin were independently effective in lowering fasting blood
glucose level in alloxan treated animals. Also chloroquine
significantly raises blood serum insulin level in diabetic animals
without exogenous insulin treatment. Chloroquine restored partially
or completely the level of transferrin, antitrypsin, acid glycoprotein
and immunoglobulin G significantly and more efficiently than
insulin. Both chloroquine and insulin had no influence on restoring
the level of albumin in diabetic mice. The results indicate that
chloroquine treatment may be a good adjuvant therapy with insulin to
control diabetes and its complications.
Research Authors
Mahmoud, Abdallah B.; Alghriany, Alshaimaa A.; Shakor, Abo Bakr M. Abdel
